1/13. Generalized acanthosis nigricans in early childhood.acanthosis nigricans (AN) is a disorder often accompanied by internal malignancy in adult patients, but in children it is usually benign. Generalized forms of AN, especially in childhood, are extremely rare. We report a 5-year-old boy with a 3-year history of AN who had generalized roughness and hyperpigmentation, numerous skin wrinkles, disseminated skin tags, tripe palms, and intensive pruritus. No clinical evidence of internal disorders, notably of an endocrinologic or neoplastic nature, have been detected thus far.- - - - - - - - - - ranking = 1keywords = palm (Clic here for more details about this article) |
2/13. acanthosis nigricans with endometrial carcinoma: case report and review of the literature.BACKGROUND: acanthosis nigricans is classified into benign and malignant forms on the basis of clinical associations. The main interest in acanthosis nigricans has been based on its association with malignancy because of the dramatic clinical appearance of the skin lesions and the usually rapidly fatal nature of the underlying disease. "Tripe palms" is a descriptive term of acanthosis nigricans of the palms. It more often is associated with internal malignancy. Most importantly, it often precedes the diagnosis of a new or recurrent tumor. Malignant acanthosis nigricans is most commonly associated with intra-abdominal malignancies. There are very few reports in the literature of malignant acanthosis nigricans associated with gynecological malignancies. Only five cases of endometrial carcinoma associated with acanthosis nigricans and/or tripe palms have been reported in the literature. CASE: A 69-year-old African-American female presented with skin changes consistent with the diagnosis of acanthosis nigricans and tripe palms. More than 14 months later she was found to have endometrial carcinoma. She subsequently underwent total abdominal hysterectomy and salpingo-oophorectomy followed by chemotherapy with paclitaxel and carboplatin. During treatment of the underlying malignancy the skin condition dramatically improved. CONCLUSION: Tripe palms can be associated with endometrial carcinoma and may be the first sign of malignancy. Malignant acanthosis nigricans may improve with treatment of the underlying malignancy. patients who present with tripe palms may need to undergo workup to search for underlying malignancy.- - - - - - - - - - ranking = 6keywords = palm (Clic here for more details about this article) |
3/13. ectodermal dysplasia with acanthosis nigricans (Lelis syndrome).A 31-year-old male patient with ectodermal dysplasia and acanthosis nigricans is described. Clinical findings included hypotrichosis, hypohidrosis, palmoplantar hyperkeratosis, nail dystrophy, early onset loss of permanent dentition, mental retardation, and acanthosis nigricans. The findings suggest the diagnosis of Lelis syndrome, as described on the basis of seven unrelated cases. A review concerning this condition is also presented.- - - - - - - - - - ranking = 1keywords = palm (Clic here for more details about this article) |
4/13. Improvement of acanthosis nigricans on isotretinoin and metformin.acanthosis nigricans (AN) is an eruption of hyperpigmented, velvety thickened patches, often with papillomatosis, that occurs symmetrically on any body site but most commonly at the axillae, neck, groin, and flexural surfaces. We report a case of a 55-year-old obese male who developed acanthosis nigricans with striking papillomatosis and tripe palms who experienced improvement on a long-term tapering dosage of isotretinoin, with additional benefit with the addition of metformin. While oral retinoids have been reported to positively impact AN, improvement of AN with metformin has been reported in only two prior cases. Combined therapy with isotretinoin and metformin for AN has not been reported previously.- - - - - - - - - - ranking = 1keywords = palm (Clic here for more details about this article) |
5/13. Oral acanthosis nigricans, tripe palms and sign of leser-trelat in a patient with gastric adenocarcinoma.acanthosis nigricans (AN), tripe palms (TP) and the sign of Leser-Trelat (LT) may be seen with the presence of malignancy. acanthosis nigricans may have a mucocutaneous localization involving the oral mucosa with papillomatous and verrucous lesions usually on the lips and buccal mucosa. These paraneoplastic dermatoses are generally linked with intra-abdominal malignancy, most often gastric adenocarcinoma. Improvement of the associated dermatoses after the treatment of the malignancy has been frequently observed. We report the case of a 53-year-old man suffering from advanced gastric adenocarcinoma, in which metastases seemed to sustain all three paraneoplastic dermatoses. To the best of our knowledge this is the first case of a patient showing manifestations of all three paraneoplastic dermatoses. patients presenting with this set of dermatoses should be suspected to harbor an occult malignancy, or have persistence of a known malignancy.- - - - - - - - - - ranking = 5keywords = palm (Clic here for more details about this article) |
6/13. Malignant acanthosis nigricans with liver secondaries from an occult primary adenocarcinoma of gastrointestinal tract.A 38-year-old female presented with hyperpigmented velvety plaques on the nape and the sides of the neck with diffuse pigmentation of the face and flexures suggestive of acanthosis nigricans. The dorsa of both the hands showed increased rugosity, hyperpigmentation and hyperkeratosis of the palms, suggestive of tripe palms. Investigations revealed multiple secondaries in the liver. Histopathology showed the secondaries to be from adenocarcinoma of the gastrointestinal tract.- - - - - - - - - - ranking = 2keywords = palm (Clic here for more details about this article) |
7/13. Malignant acanthosis nigricans, tripe palms and the sign of Leser-Tre'lat, a hint to the diagnosis of early stage ovarian cancer: a case report and review of the literature.BACKGROUND: Malignant acanthosis nigricans is a mucocutaneous eruption associated with internal malignancies. Tripe palms refers to a characteristic velvety thickening of the palms, with exaggeration of normal skin markings. The sign of Leser-Tre'lat is the presence of multiple seborrheic keratoses and scattered skin tags caused by a malignancy. We are reporting the first case of ovarian cancer in association with three coexisting cutaneous paraneoplastic dermatosis. CASE: A 52-year-old female presented with skin manifestation consistent with MAN, TP and the sign of Leser-Tre'lat. Patient underwent extensive work up and was discovered to have stage I, high grade adenocarcinoma of the ovary. skin manifestations gradually recovered after initiation of chemotherapy. CONCLUSION: The presence of acanthosis nigricans in conjunction with tripe palms and the sign of Leser-Tre'lat are highly suggestive of an internal malignancy and necessitate an extensive investigation in order to discover the underlying malignancy.- - - - - - - - - - ranking = 7keywords = palm (Clic here for more details about this article) |
8/13. Malignant acanthosis nigricans and tripe palms associated with pancreatic adenocarcinoma.Malignant acanthosis nigricans is a disease that has an abrupt onset and is most commonly associated with gastric adenocarcinoma. It also has occurred as a paraneoplastic phenomenon in other carcinomas. Malignant acanthosis nigricans can occur simultaneously, before, or after the onset of internal malignancy. Malignant acanthosis on the palms is referred to as tripe palms. We describe a rare association of oral malignant acanthosis nigricans and tripe palms secondary to an underlying pancreatic adenocarcinoma.- - - - - - - - - - ranking = 7keywords = palm (Clic here for more details about this article) |
9/13. Acquired pachydermatoglyphy. A cutaneous sign of internal malignancy.A 70-year-old man with hypertrophic osteoartropathy secondary to a squamous cell carcinoma of the lung presented a distinctive pattern of late-onset bilateral palmar keratoderma. A yellowish rugose appearance with accentuation of normal ridges and sulci (pachydermatoglyphy) involving the palms was observed. The differential diagnosis and the clinical relevance of acquired pachydermatoglyphy as a cutaneous marker of internal malignancy are discussed.- - - - - - - - - - ranking = 2keywords = palm (Clic here for more details about this article) |
10/13. acanthosis nigricans presenting as hyperkeratosis of the palms and soles.A patient with an unusual form of palmoplantar hyperkeratosis is described. On thorough physical examination, widespread acanthosis nigricans was discovered. We believe this patient's distinctive keratoderma represents acanthosis nigricans.- - - - - - - - - - ranking = 5keywords = palm (Clic here for more details about this article) |
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