1/28. breast cancer associated with Recklinghausen's disease: report of a case.A 49-year-old woman with Recklinghausen's disease presented to our department for investigation of a left breast lump, measuring 60 mm x 50 mm, which she had first noticed 6 months earlier, but had disregarded, believing it to be another manifestation of her Recklinghausen's disease. The lump was suspected to be malignant based on physical examination and ultrasonography. biopsy and frozen sections subsequently confirmed a diagnosis of scirrhous carcinoma. A standard radical mastectomy was performed, followed by postoperative chemoendocrine therapy. However, lungs, liver, and bone metastasis, as well as a contralateral breast tumor, developed and she died 4 months after surgery.- - - - - - - - - - ranking = 1keywords = breast (Clic here for more details about this article) |
2/28. Interstitial brachytherapy for recurrent breast cancer using a high dose rate Ir-192 remote afterloading system: a report of two cases.We employed interstitial brachytherapy using a high dose rate Ir-192 remote afterloading unit in two breast cancer patients with locoregional recurrence. In the first case, skin metastasis was treated, with favorable control of the infield tumor but subsequent persistent sequelae and multiple outfield metastases. This experience caused us to be cautious when choosing brachytherapy for the second case, in whom a solitary metastasis to an axillary lymph node was successfully treated. Although this method is still investigational, it may play a critical role in the treatment of locoregional recurrence resistant to other treatment modalities.- - - - - - - - - - ranking = 2.5keywords = breast (Clic here for more details about this article) |
3/28. intestinal perforation due to metastasis of breast carcinoma, with special reference to chemotherapy: a case report.We report a case of small-bowel perforation due to metastatic carcinoma of the breast during chemotherapy. Partial resection of the small intestine and primary anastomosis were performed. Although the patient made a good recovery from panperitonitis, she died of the disease on the 55th postoperative day. Since perforation during chemotherapy results in an extremely poor prognosis, special caution during chemotherapy is needed for patients with possible gastrointestinal involvement with tumor.- - - - - - - - - - ranking = 2.5keywords = breast (Clic here for more details about this article) |
4/28. Carcinoma of the male breast metastatic to the mandible.A case is reported of male breast carcinoma which, among other bony sites, metastasized to the mandible. This case and the review of the literature illustrate the need to include the mandible in bone scans for metastatic disease in breast cancer.- - - - - - - - - - ranking = 3keywords = breast (Clic here for more details about this article) |
5/28. Scirrhous colonic metastasis from ductal carcinoma of the breast: report of a case.Metastasis of breast cancer to the colon is rare. We report a case of a 49-year-old female who presented with a stenotic tumor of the descending colon five years after treatment of breast cancer with mastectomy and pedicled transverse rectus abdominis musculocutaneous flap. laparotomy showed a diffusely infiltrated tumor over the descending colon. Anterior resection with loop ileostomy was performed, and the pathology showed that the colonic wall and the mesentery were diffusely infiltrated with poorly differentiated adenocarcinoma, which stained strongly for cytokeratin 7. The histologic diagnosis is consistent with colonic metastasis from ductal carcinoma of breast origin. In a patient with a history of breast cancer, colonic metastasis from the breast primary cancer should be considered, especially if the colonic lesion is scirrhous in nature. The incision for laparotomy and the probable stoma site should be planned carefully in females after breast reconstructive surgery.- - - - - - - - - - ranking = 5keywords = breast (Clic here for more details about this article) |
6/28. Multiple (multicentric and multifocal) cancers in the ipsilateral breast with different histologies: profiles of chromosomal numerical abnormality.BACKGROUND: Chromosomal numerical abnormality (CNA) is a characteristic of breast cancer as with other common solid cancers. Multiple mammary carcinomas are also sometimes encountered in the ipsilateral breast. Deciding whether they are multicentric (arising independently) or multifocal (of the same origin) has been a continued challenge to clinicians and pathologists. methods: We experienced two cases of macroscopically distinct double carcinomas in the ipsilateral breast, in which two cancers had a different histopathological morphology. centromere probes identifying 17 different and specific centromeres were used to obtain the profile of CNA for each tumor, with a microwave-assisted FISH protocol. For comparison, a case of three lesions, two of which had the same and the other different histology was also studied. RESULTS: Contrary to our expectations, in spite of the particular difference in the histopathological picture of these tumors, the CNA profile was the same in one case and different in the other. The gain of chromosome 1 and loss of chromosome 15 are representative features shared by multifocal cases. On the other hand, the multiple cancers with the same histology had mostly the same CNA profile. CONCLUSIONS: CNA profiling is useful to identify the lineage of multiple breast cancers. As shown here, regardless of the histological features, a certain common CNA profile can define the same origin of some multiple cancers.- - - - - - - - - - ranking = 4keywords = breast (Clic here for more details about this article) |
7/28. Detection of the estrogen receptor and response to endocrine therapy in male breast cancer patients.The estrogen receptor was measured in breast cancer of two male patients. Both patients had a positive receptor content in their tumors. The dissociation constant and number of binding sites were both very similar to those in the female counterpart. In one of the patients, the number of binding sites in the metastatic lesions of the liver was similar to that in the primary site. The patient responded well to the endocrine ablation therapy with a remission period of 8 months. The estrogen receptor was found to be positive in 12 out of 14 cases of male breast cancer reported previously including the present 2 patients. Three out of 4 cases with positive receptor contnet, including the present case, responded to orchiectomy.- - - - - - - - - - ranking = 3keywords = breast (Clic here for more details about this article) |
8/28. Early detection of breast cancer.One thousand referred patients with breast symptoms, a history of breast disease, or a family history of breast carcinoma have been examined at a suburban breast clinic. This is a preliminary survey of the data and results so far obtained from the initial examination of these patients. The examination consisted of history-taking by means of a questionnaire, physical examination of the breasts, thermography and xeromammography. A report correlating the findings was forwarded to the referring doctor in each case and any necessary action was indicated in the report. Seventy-eight patients were thought to require biopsy of a suspicious lump or mammographic lesion (7.8% of the total number); 76 patients actually had biopsies, and 18 patients were found to have carcinoma of the breast (23.8% of the total number of patients who had biopsies). The overall incidence of carcinoma in the 1000 women attending the clinic was 1.8% at the initial visit. While general population screening for breast carcinoma may be hard to justify, from both the detection rate and an economic point of view, it would appear from our experience to date that screening of selected high-risk referred patients is justified and, in fact, desirable.- - - - - - - - - - ranking = 5.5keywords = breast (Clic here for more details about this article) |
9/28. Malignant cystosarcoma phyllodes associated with scirrhous carcinoma of the breast: a case report.The presence of a malignant cystosarcoma phyllodes in one breast and a scirrhous carcinoma in the opposite breast in a premenopausal Black woman is described. Malignant cystosarcoma phyllodes is uncommon and its rare association with carcinoma of the breast is mentioned.- - - - - - - - - - ranking = 3.5keywords = breast (Clic here for more details about this article) |
10/28. Multicentric reticulohistiocytosis and malignant disease.Multicentric reticulohistiocytosis developed in a 45-year-old woman, who had a 3 year history of untreated breast carcinoma. A review of the literature revealed that malignant disease has been associated with 27% of reported cases. It is considered that, like adult dermatomyositis, the onset of multicentric reticulohistiocytosis should stimulate detailed investigation for an underlying neoplasm.- - - - - - - - - - ranking = 0.5keywords = breast (Clic here for more details about this article) |
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