1/55. Synchronous unilateral parotid neoplasms of different histological types.The occurrence of multiple tumours in the salivary glands is an unusual phenomenon and the simultaneous development of tumours different types is extremely rare. Two cases are presented with synchronous tumours of the parotid gland of different histological types. The first was a Warthin tumour in combination with a metastatic lung carcinoma and the second was a pleomorphic adenoma in combination with non-Hodgkin's malignant lymphoma.- - - - - - - - - - ranking = 1keywords = carcinoma (Clic here for more details about this article) |
2/55. Squamous cell carcinoma arising in a Warthin's tumor.Warthin's tumor is a well-defined salivary gland neoplasm consisting of epithelial and lymphoid components. However, malignant transformation is extremely rare. Such a patient who developed squamous cell carcinoma within a Warthin's tumor of the parotid gland is described and possible pathogenesis is discussed.- - - - - - - - - - ranking = 5keywords = carcinoma (Clic here for more details about this article) |
3/55. Synchronous ipsilateral sebaceous lymphadenoma and acinic cell adenocarcinoma of the parotid gland.The synchronous or metachronous occurrence of 2 tumors of the salivary glands in a patient is rare. These tumors are usually benign and of the same histologic type. Here we report a 78-year-old woman who developed a sebaceous lymphadenoma and an acinic cell adenocarcinoma simultaneously in the left parotid gland. To our knowledge, this combination of neoplasms has not been reported before.- - - - - - - - - - ranking = 5keywords = carcinoma (Clic here for more details about this article) |
4/55. Mucoepidermoid carcinoma arising within a Warthin's tumor.A case of low-grade mucoepidermoid carcinoma arising within a Warthin's tumor is reported. The carcinoma appeared to have originated from the hyperplastic atypical epithelium of the Warthin's tumor. It did not infiltrate the capsule of the lymph node in which the Warthin's tumor developed. After 6 years of follow-up, there is no evidence of recurrence or metastasis. The literature on malignant Warthin's tumor is reviewed.- - - - - - - - - - ranking = 6keywords = carcinoma (Clic here for more details about this article) |
5/55. Intraoral papillary cystadenoma lymphomatosum.The literature related to intraoral papillary cystadenoma lymphomatosum is critically reviewed and the reported cases analyzed to determine the average age, sex, and race of patients, and the site distribution of this curious lesion. Two new cases are reported. The histogenesis and differential diagnosis from cystadenocarcinoma are briefly discussed.- - - - - - - - - - ranking = 1keywords = carcinoma (Clic here for more details about this article) |
6/55. Warthin-like tumour of the thyroid gland: RET/PTC expression indicates it is a variant of papillary carcinoma.AIMS: Three cases with features of so-called 'Warthin-like tumour' of the thyroid (WaLTT) are described, in order to evaluate its relationship with papillary carcinoma (PC). methods AND RESULTS: We performed an histological and immunohistochemical study with emphasis on RET/PTC expression. The most striking features are represented by marked lymphocytic infiltration in the stalks of papillae and by oxyphilic metaplasia of epithelium, resembling Warthin tumour of the salivary gland. In all cases, we found nuclear features reminiscent of PC. The neoplastic cells were strongly positive for Leu M1 and epithelial membrane antigen (EMA), less for thyroglobulin and negative for calcitonin. The lymphocytic infiltrate was composed of a mixed population of B and T-cells with sparse S100-positive langerhans cells. An interesting finding was the strong positivity with the antibody against RET/PTC. CONCLUSION: All clinicopathological data along with the presence of the extensive lymphocytic infiltrate could imply a more favourable prognosis. The expression of RET/PTC fusion gene adds support to the hypothesis that this tumour is a variant of PC, probably related to the oncocytic variant of PC.- - - - - - - - - - ranking = 5keywords = carcinoma (Clic here for more details about this article) |
7/55. Warthin-like papillary carcinoma of the thyroid.BACKGROUND: Warthin-like papillary carcinoma of thyroid is characterized by distinct papillary formations lined by tumor cells with oncocytic cytoplasm, nuclear features of papillary carcinoma, and brisk lymphoplasmacytic infiltrates in the papillary stalks. This tumor derives its name from its close resemblance to Warthin tumor of major salivary glands. DESIGN: The clinicopathologic features of 17 patients with Warthin-like papillary carcinoma were studied. RESULTS: Fifteen tumors occurred in women and 2 arose in men (age range, 23-63 years). The lesions ranged in size from 3 mm to 2.5 cm. Fine-needle aspiration biopsies were performed in 7 cases; 4 were diagnosed as papillary carcinoma, 2 as consistent with lymphocytic thyroiditis, and 1 as atypical cells. All 17 tumors were confined to the thyroid; 6 showed prominent cyst formation and the remaining tumors were solid. In each case, the tumor arose in a background of lymphocytic thyroiditis. Nodal metastases were identified in 3 cases; however, none showed distant metastases. In 7 cases, foci of papillary microcarcinoma and follicular variant of papillary carcinoma were found in other areas of the thyroid. CONCLUSIONS: Warthin-like tumors can be mistaken for benign lymphoepithelial lesions of the thyroid, Hurthle cell carcinoma, and tall cell variant of papillary carcinoma in both fine-needle aspiration and histology specimens. Follow-up information on the previously reported cases has suggested that these tumors behave similarly to usual papillary carcinoma. The extensive lymphocytic infiltration in these tumors and their association with chronic lymphocytic thyroiditis may suggest a role for immunological mechanisms in the pathogenesis of thyroid tumors.- - - - - - - - - - ranking = 13keywords = carcinoma (Clic here for more details about this article) |
8/55. Mucoepidermoid carcinoma involving Warthin tumor. A report of five cases and review of the literature.We describe 5 cases of mucoepidermoid carcinoma (MEC) involving Warthin tumor (WT) of the parotid gland. The WT size ranged from 1.7 to 6.0 cm. The MECs were much smaller, 0.3 to 1.7 cm. In 3 cases, the WT completely surrounded the MEC, and in 2 cases neither WT nor MEC surrounded the other. Each MEC was low grade, 3 grade I and 2 grade II. One MEC had evidence of vascular invasion. All patients underwent partial or subtotal parotidectomy with negative resection margins. Clinical follow-up (range, 8-52 months) for 3 patients showed no evidence of recurrence. The pathogenetic relationship between WT and MEC in these cases is uncertain. In 4 cases, foci of squamous or mucous metaplasia were found in the WT component, associated with mild cytologic atypia in 3 tumors. However, a direct transition from WT to MEC was not identified. In 1 case, MEC was present 45 months before WT, suggesting that the recurrent MEC involved WT coincidentally. The small size and low grade of the MEC and the negative resection margins most likely explain the good outcome for the 3 patients with clinical follow-up data available.- - - - - - - - - - ranking = 5keywords = carcinoma (Clic here for more details about this article) |
9/55. Fine-needle aspiration cytology of lymphangioma of the parotid gland in an adult.lymphangioma or cystic hygroma is an uncommon benign congenital tumor of lymphatics that is seen in children and, rarely, adults. lymphangioma primarily involving the parotid gland is an extremely uncommon occurrence in adults. We report on the cytologic findings of a parotid lymphangioma in a 34-yr-old man which showed 13 cc of yellow fluid with red blood cells, lymphocytes, and rare fragments of benign-appearing salivary gland epithelium. The differential diagnosis of cystic parotid gland lesions in adults may include Warthin's tumor, lymphoma, benign lymphoepithelial lesions, branchial cleft cysts, chronic sialadenitis, cystic low-grade mucoepidermoid carcinoma, and cystic pleomorphic adenoma. In this case, the fine-needle aspiration findings along with the magnetic resonance imaging (MRI) findings of a multiloculated cystic mass in the parotid gland allowed the diagnosis of lymphangioma.- - - - - - - - - - ranking = 1keywords = carcinoma (Clic here for more details about this article) |
10/55. Multiple primary tumors. Four distinct head and neck tumors.The case history of a 70-year-old woman with the simultaneous occurrence of mucoepidermoid carcinoma of the parotid gland, thyroid carcinoma, squamous cell carcinoma of the oral cavity, and a Warthin tumor is described. The simultaneous occurrence of three histologically distinct malignant tumors is a rare event amounting to approximately 1% of cases of multiple primary tumors. This case is unusual in that the tumors occurred in three separate organs and in association with a papillary cystadenoma lymphomatosum. While difficult to evaluate, prognosis and treatment should be approached with respect to each of the tumors as individual entities.- - - - - - - - - - ranking = 3keywords = carcinoma (Clic here for more details about this article) |
| | Next -> |