1/28. Pancreatic somatostatinoma: a case report and review of the literature.A 56-year-old man underwent distal pancreatectomy, splenectomy, and partial resection of the splenic flexure of the colon because of tumor in the tail of pancreas and the splenic hilus. The patient presented with symptoms of general malaise, anorexia, weight loss, mild diarrhea, and borderline diabetes mellitus, although there was no cholelithiasis. The diagnosis remained unclear until immunohistochemical studies of the resected specimen revealed somatostatin and synaptophysin, suggesting a somatostatinoma. Twenty-three reported cases of pancreatic somatostatinoma are reviewed and their clinical features discussed. The role of immunohistochemical studies in the diagnosis of somatostatinoma is described.- - - - - - - - - - ranking = 1keywords = somatostatinoma (Clic here for more details about this article) |
2/28. Duodenal carcinoid (somatostatinoma) combined with von Recklinghausen's disease. A case report and review of the literature.We report the immunohistochemical and ultrastructural features of a case of duodenal carcinoid (somatostatinoma) combined with cutaneous-type von Recklinghausen's disease in a 65-year-old woman. The duodenal tumor located at the 2nd portion was composed of tumor cells arranged in a trabecular, glandular or nest-like pattern, occasionally associated with eosinophilic globules in the glandular structures. The tumor cells mostly showed strong immunoreactivity with anti-somatostatin antibody. Electron microscopy revealed that every tumor cell contained intracytoplasmic granules with electron-dense cores, 100-300 nm in size, in varying numbers, and intracytoplasmic lumina were rarely detected. The present case including identical cases reported so far suggest that the disease entity is likely to be a combination of duodenal somatostatinoma and von Recklinghausen's disease and/or phaeochromocytoma. This is the tenth case of duodenal carcinoid associated with von Recklinghausen's disease and/or phaeochromocytoma in the world literature and the third case reported as duodenal somatostatinoma.- - - - - - - - - - ranking = 1keywords = somatostatinoma (Clic here for more details about this article) |
3/28. Duodenal somatostatinoma with psammoma bodies.A duodenal somatostatinoma was found incidentally in a 60-year-old woman undergoing cholecystectomy. Microscopically, the tumor had a glandular architecture with abundant psammoma bodies. Electron microscopy revealed tumor cells resembling D-cells of the pancreatic islets. Immunohistochemically, there was staining for neuron-specific enolase, chromogranin, and diffuse cytoplasmic positivity for somatostatin only. By immunoelectron microscopy, somatostatin was identified predominantly in lucent membrane-bound secretory granules. X-ray-dispersive microanalysis showed the psammoma bodies contained calcium apatite crystals. This case is compared with other reported cases with a description of cellular localization of somatostatin and development of psammomatous calcification.- - - - - - - - - - ranking = 0.71428571428571keywords = somatostatinoma (Clic here for more details about this article) |
4/28. Malignant somatostatinoma presenting with diabetic ketoacidosis.High circulating levels of somatostatin (SRIF) were detected in a patient with a metastatic tumour after development of diabetic ketoacidosis (DKA). fasting insulin and c-peptide levels were markedly suppressed, but plasma glucagon was not suppressed below normal. Progressive cachexia ensued; at autopsy a poorly differentiated non-small cell neuroendocrine carcinoma metastatic to liver was found. Small gallstones were noted. Electron microscopy of tumour tissue showed neurosecretory granules and tonofilament bundles. Immunohistochemical staining of tumour cells was diffusely positive for carcinoembryonic antigen, bombesin-like immunoreactivity, and calcitonin with focal immunoreactivity for SRIF, serotonin, neuron-specific enolase, chromogranin, and epithelial membrane antigen. Column chromatography of plasma and tumour extract revealed five or more peaks of material with SRIF-like immunoreactivity (SRIF-LI): predominantly SRIF-28 and intermediates in tumour extract, and SRIF-14 and an intermediate between SRIF-28 and SRIF-14 in plasma, DKA in this case of somatostatinoma syndrome may reflect differential effects of tumour production of larger molecular weight SRIF forms on insulin and glucagon secretion.- - - - - - - - - - ranking = 0.71428571428571keywords = somatostatinoma (Clic here for more details about this article) |
5/28. A polypoid duodenal somatostatinoma. A case report.A case of a pedunculated, polypoid duodenal somatostatinoma is presented. The clinical and pathologic aspects of duodenal somatostatinomas are summarized and briefly discussed.- - - - - - - - - - ranking = 0.85714285714286keywords = somatostatinoma (Clic here for more details about this article) |
6/28. Ampullary somatostatinoma. An immunohistochemical and ultrastructural study.Two new cases of ampullary somatostatinoma are reported. In one case the tumor is associated with an increase in somatostatin-positive cells in the adjacent duodenal mucosa. Both tumors show a predominant glandular pattern with many psammomatous calcified bodies. Such bodies seem to arise by calcium phosphate encrustation of intraluminal cellular debris. The neoplastic cells contain two distinct types of intermediate filaments: the first is located along the plasma membrane and reacts to keratin antiserum; the other, appearing as paranuclear aggregates, reacts to neurofilament antiserum. The neoplastic cells show signs of intestinal differentiation (microvilli, glycocalyceal bodies, filamentous core rootlets) as well as of neuroendocrine differentiation (secretory granules, whorls of neurofilaments).- - - - - - - - - - ranking = 0.71428571428571keywords = somatostatinoma (Clic here for more details about this article) |
7/28. Pancreatic somatostatinoma: presentation with recurrent episodes of severe hyperglycaemia and ketoacidosis.A 47-year-old woman was admitted on four occasions over a four-year period with severe hyperglycaemia associated with marked ketoacidosis. She had weight loss with hepatomegaly and ultrasonography indicated a pancreatic tumour which was shown to be a somatostatinoma. Resection resulted in prolonged survival. The biochemical and morphological features of this rare tumour are presented, and an explanation for the unusual presentation of a somatostatinoma with episodes of ketoacidosis is given.- - - - - - - - - - ranking = 0.85714285714286keywords = somatostatinoma (Clic here for more details about this article) |
8/28. Early somatostatinoma of the papilla of the duct of Santorini.We studied a patient with a very small somatostatinoma that arose from the prominence of the orifice of the duct of Santorini. The patient presented clinically with epigastric discomfort, marked loss of weight, diarrhea, exertional dyspnea, and chest pain. He flushed intermittently and had occasional tachycardia and hypertension. Levels of serum serotonin and urinary 5-hydroxyindoleacetic acid were normal. A small ampullary tumor was resected and identified by immunohistochemical staining to be a somatostatinoma. The patient had gained 6.75 kg and was essentially free of symptoms 16 months after surgery.- - - - - - - - - - ranking = 0.85714285714286keywords = somatostatinoma (Clic here for more details about this article) |
9/28. somatostatinoma of the pancreas.A case of a pancreatic somatostatinoma in a 74-year-old male is presented. It was very difficult to establish the clinical diagnosis because of absence of typical symptoms. However, it was very easy to establish the histological diagnosis because typical cytoplasmic neurosecretory granules (D-cell granules) and immunoreactivity for somatostatin were demonstrated. Moreover, immunoassay of tumor tissues enables one to not only establish a definitive diagnosis but also to demonstrate multiple hormone production.- - - - - - - - - - ranking = 0.14285714285714keywords = somatostatinoma (Clic here for more details about this article) |
10/28. Duodenal somatostatinoma with psammoma bodies: an immunohistochemical and ultrastructural study.We report a case of malignant somatostatinoma of the ampulla of vater in a 38-year-old woman with diabetes and cholelithiasis. immunohistochemistry showed that tumor cells contained only somatostatin and electron microscopy revealed D-type granules in their cytoplasm. Psammoma bodies were numerous and appeared to originate in the cytoplasm of somatostatin producing cells. A review of the literature reveals that somatostatinomas with psammoma bodies are found only in the duodenum and do not produce significant amounts of peptides other than somatostatin.- - - - - - - - - - ranking = 0.85714285714286keywords = somatostatinoma (Clic here for more details about this article) |
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