1/63. Multiple hepatocellular adenomas in a patient with a history of oral contraception.We report a previously undescribed association between multiple hepatocellular adenomas and the use of oral contraceptives in a 29-year-old woman. She underwent trisegmentectomy, with 90% of the liver resected. Based on the rather large size of some of the adenomas at the time of diagnosis, most likely, the lesions were already present years before they were discovered. The liver was fully regenerated 6 months after surgery. Four years later, multiple adenomas recurred. During work-up for a liver transplant, she was found to have cryptococcal meningitis and pneumohydrocephalus which caused her demise.- - - - - - - - - - ranking = 1keywords = adenoma (Clic here for more details about this article) |
2/63. Ruptured hepatic adenoma in liver adenomatosis: a case report of emergency surgical management.In hepatic adenomatosis, multiple liver cell adenomas (usually > or = 10) generally affects patients with no prior history of oral contraceptive use, androgenic steroid use, or glycogen storage disease. We report a rare case of a 44 year-old female who underwent emergency surgery for hemoperitoneum due to spontaneous rupture of a liver cell adenoma in hepatic adenomatosis, after prolonged use of two different contraceptives (Gestodene and Ethinylestradiol).- - - - - - - - - - ranking = 1.7142857142857keywords = adenoma (Clic here for more details about this article) |
3/63. A 42-year-old woman with liver masses and long-term use of oral contraceptives.A 42-year-old woman with a history of 25-year oral contraceptive use presented with abdominal pain and was found to have two exophytic liver masses. She had no known prior liver diseases, and her serum liver enzyme and AFP levels were normal. One of the masses was a hepatocellular adenoma and the other was a pigmented hepatocellular carcinoma. The exophytic appearance of both lesions was unusual. This case, once more, demonstrated the risk of hepatocellular adenomas to undergo malignant transformation. The reason for the brown pigment deposition in the hepatocellular carcinoma was not clear. The prognosis was expected to be excellent following complete surgical resection.- - - - - - - - - - ranking = 0.28571428571429keywords = adenoma (Clic here for more details about this article) |
4/63. Spontaneous hepatocellular adenoma with marked cystic degeneration.We report a case of spontaneous hepatocellular adenoma with marked cystic degeneration in the non-cirrhotic liver. A 36 year-old Japanese woman with neither history of liver diseases nor use of oral contraceptives and steroids, complained of a 6 kg weight loss over 6 months. barium meal study revealed an extramural compression along the fornix of the stomach. Abdominal ultrasonography (UC) and computed tomography (CT) demonstrated a mass in the left lateral segment of the liver that measured 11.6x9.5 cm with cystic lesions. Laboratory data on admission showed no significant findings. Celiac angiography revealed a hyper-vascular mass. Surgical exploration revealed a soft mass arising and protruding from the left lateral segment of the liver. Partial resection of the left lateral segment was performed. Histologically, the tumor was surrounded by a thin fibrous pseudocapsule. The neoplastic cells resembling normal hepatocytes around the tumor were large, pale and arranged in thick, irregular cords. Neither mitotic figures nor foci of dysplasia were present. The central portions of the tumor showed marked cystic degeneration. The tumor was histologically diagnosed as hepatocellular adenoma (HCA). HCA with cystic degeneration has been rarely reported.- - - - - - - - - - ranking = 0.85714285714286keywords = adenoma (Clic here for more details about this article) |
5/63. Hepatocellular adenomatosis associated with hereditary haemochromatosis.A young healthy man presented with abdominal pain following an accidental fall. Imaging studies and laparoscopy revealed multiple yellowish well-defined hepatic lesions. Liver biopsies showed hepatic adenomas and iron overload. Laboratory investigation confirmed a diagnosis of hereditary haemochromatosis. To our knowledge this represents the first report of an association of hepatic adenomatosis and primary haemochromatosis.- - - - - - - - - - ranking = 0.85714285714286keywords = adenoma (Clic here for more details about this article) |
6/63. Pigmented liver cell adenoma in two male patients.We report two cases of hepatocyte neoplasia with extensive deposition of Dubin-Johnson-like pigment in men without Dubin-Johnson syndrome. This pigment has previously been described in hepatocellular carcinoma but not in liver cell adenoma. The tumors of both patients showed some atypical cytologic features, but no frank histologic evidence of malignancy. Long-term follow up for several years showed no evidence of recurrence after limited surgical excision. We conclude that tumors with this structure may be cured by limited surgical excision and should be considered as pigmented liver cell adenomas.- - - - - - - - - - ranking = 0.85714285714286keywords = adenoma (Clic here for more details about this article) |
7/63. Multiple black hepatocellular adenomas in a male patient.A 65-year-old man presented with multiple liver tumours. Imaging techniques could not differentiate between adenomas and hepatocellular carcinomas. He had no relevant past medical history. liver function tests were normal except for a 1.5-fold rise in GGT. AFP was normal. Viral markers were negative. During laparoscopy, numerous black tumours of different sizes were seen. These tumours were adenomas without malignant transformation. Tumoral hepatocytes contained a brown pigment in the canalicular area without evidence of cholestasis. This pigment was Fontana positive and looked like Dubin-Johnson pigment by electron microscopy. The expression of the canalicular multispecific organic anion transporter (cMOAT) was decreased in the tumours but normal in the non-tumoral liver ruling out the diagnosis of Dubin-Johnson syndrome. There was mild iron deposition possibly related to an homozygous H63D mutation in the HFE gene. Three years after their discovery, the size of the tumours remained stable. It is concluded that this male patient with multiple adenomas and mild iron overload is at risk of developing an hepatocellular carcinoma and that the black colour of adenomas is probably due to a partial defect in excretion of organic anions.- - - - - - - - - - ranking = 1.1428571428571keywords = adenoma (Clic here for more details about this article) |
8/63. Hepatic adenomatosis: gadolinium-enhanced dynamic MR findings.Hepatic adenomatosis is a rarely encountered liver disease. It is an entity distinct from hepatocellular adenoma and is characterized by the presence of more than 10 hepatic adenomas. We present the multiplanar and multiphasic dynamic magnetic resonance findings of hepatic adenomatosis in a 15-year-old adolescent who developed transfusional hemosiderosis and had received anabolic steroids for the treatment of aplastic anemia.- - - - - - - - - - ranking = 1.1428571428571keywords = adenoma (Clic here for more details about this article) |
9/63. Rapid disappearance of hepatic adenoma after contraceptive withdrawal.We present the case of a 25-year-old woman who developed a large central liver adenoma after 8 years of continuous oral contraceptive use. The first diagnosis was made by ultrasonography, after a rise in plasmatic gamma-glutamyl-transpeptidase and alkaline phosphatase levels was noted. Withdrawal of the oral contraceptive was followed by shrinkage of the adenoma, with complete disappearance 9 months after the diagnosis. Hepatic adenoma (HA) still presents problems in terms of differential diagnosis and clinical management. There are reports of complete or partial regression of an HA after discontinuation of oral contraceptives, but they are poorly documented. To our knowledge, a patient with such rapid disappearance of a large HA has never been reported.- - - - - - - - - - ranking = 1keywords = adenoma (Clic here for more details about this article) |
10/63. rupture of liver cell adenoma with fatal massive hemoperitoneum resulting from minor road accident.Blunt abdominal trauma can cause rapid death resulting from serious injuries of internal organs. The liver is commonly involved and may show tearing, usually in its upper surface, resulting in hemoperitoneum eventually leading to death. Minor trauma implies serious liver damage only when previous pathologic changes causing enlargement of the organ are present. The case of a 25-year-old woman who died as a consequence of a minor road accident is reported. At autopsy, the body showed no external injuries, the only relevant finding being a massive hemoperitoneum from the rupture of an unusually large liver cell adenoma. Liver cell adenomas carry a serious risk of spontaneous rupture, which may result in the death of the patient. The occurrence of the rupture after a minor blunt abdominal trauma is highly unusual.- - - - - - - - - - ranking = 0.85714285714286keywords = adenoma (Clic here for more details about this article) |
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