1/17. Epithelial changes in early primary herpes simplex virus keratitis. Photomicrographic observations in a case of human infection.PURPOSE: To report the morphology of early corneal epithelial changes in primary herpes simplex virus type 1 (HSV 1), and to compare it to that of recurrent HSV 1 and adenovirus keratitis. methods: A 23-year-old man examined with the slit lamp and photographed by non-contact in vivo photomicrography. RESULTS: 3 days after onset the cornea showed myriads of clear epithelial vesicles, two rounded limbal epithelial foci, and scattered, faintly discernible incipient ones. On day 5 several partly confluent foci, and on day 6 typical HSV dendrites were present. HSV 1 was isolated. Serological tests confirmed primary disease. CONCLUSION: The early stage of primary HSV epithelial keratitis differed from recurrent disease by the presence of large numbers of clear vesicles. The photographs, however, captured similar early changes as in recurrent disease, and the subsequent development followed the same pattern. The main sign differentiating primary HSV from adenovirus infections was the early presence of epithelial foci with ulcerative features.- - - - - - - - - - ranking = 1keywords = keratitis, herpes simplex, simplex, herpes (Clic here for more details about this article) |
2/17. Coexistent adenoviral keratoconjunctivitis and acanthamoeba keratitis.A 17-year-old youth presented with bilateral follicular conjunctivitis and nummular subepithelial corneal infiltrates. Failure of this to settle in an outpatient setting led to corneal scraping with microscopy and culturing for bacteria, fungi, herpes simplex, adenovirus and Acanthamoeba as an inpatient. polymerase chain reaction analysis of corneal cells was positive for adenovirus, and culture on live escherichia coli-coated agar plates was positive for Acanthamoeba by phase contrast microscopy on day two. We conclude that Acanthomoeba infection can complicate adenoviral keratoconjunctivitis. This observation is in keeping with previously reported modes of infection by Acanthamoeba, whereby any epithelial breach seems to allow inoculation of the eye by this opportunistic organism.- - - - - - - - - - ranking = 0.49242118887293keywords = keratitis, simplex (Clic here for more details about this article) |
3/17. Reactivation of presumed adenoviral keratitis after laser in situ keratomileusis.We report a patient with reactivation of presumed adenoviral keratoconjunctivitis after laser in situ keratomileusis (LASIK) to correct high myopia. The preoperative refraction was -13.00 diopters (D) in the right eye and -14.00 D in the left eye, and the best corrected visual acuity was 20/20 in both eyes. On the first postoperative day, mild conjunctival hyperemia and multiple subepithelial infiltrations localized in the flap zone consistent with adenoviral keratoconjunctivitis were seen. After prompt treatment, the lesions resolved. As a consequence, LASIK successfully corrected the high myopia. Adenoviral keratoconjunctivitis can be reactivated after LASIK, unlike after photorefractive keratectomy, despite the absence of symptomatic and clinical findings before the procedure.- - - - - - - - - - ranking = 0.48469919254894keywords = keratitis (Clic here for more details about this article) |
4/17. Adenovirus pneumonia with severe sequelae in an immunocompetent adult.Notable complications from adenovirus pneumonia in healthy adults are rare. We report a well-documented case of adenovirus type 3 infection in a previously well adult woman that resulted in severe pulmonary complications as well as self-limited ocular, hepatic, and gastrointestinal abnormalities.- - - - - - - - - - ranking = 4.903091205493E-5keywords = ocular (Clic here for more details about this article) |
5/17. Delayed reactivation of presumed adenoviral subepithelial infiltrates after laser in situ keratomileusis.OBJECTIVE: To report the reactivation of presumed adenoviral keratitis after laser in situ keratomileusis (LASIK). methods: Case report and literature review. RESULTS: The patient underwent uneventful LASIK more than 5 years after an episode of adenoviral keratitis that left subepithelial corneal scarring. Three months after LASIK, new subepithelial infiltrates appeared in the right eye. These lesions resolved without sequelae during treatment with topical steroids. The patient's uncorrected and best-corrected visual acuity returned to her postoperative baseline. CONCLUSION: LASIK may cause delayed exacerbation of subepithelial infiltrates caused by adenoviral keratitis. However, good visual outcomes can be achieved with recognition of this reactivation and treatment with topical corticosteroids.- - - - - - - - - - ranking = 0.36352439441171keywords = keratitis (Clic here for more details about this article) |
6/17. Subepithelial infiltrates associated to viral keratoconjunctivitis following photorefractive keratectomy.PURPOSE: To report three cases of adenoviral keratoconjunctivitis in patients who have undergone photorefractive keratectomy and that just developed subepithelial infiltrates. methods: Description of patients that developed postoperative adenoviral keratoconjunctivitis after photorefractive keratectomy without influence in the final visual outcome. RESULTS: All patients presented adenoviral keratoconjunctivitis 2-3 months after refractive surgery. They developed multiple pinpoint subepithelial infiltrates in six eyes, without haze development. The final uncorrected visual acuity was better or equal to 20/30. CONCLUSION: Although patients undergoing photorefractive keratectomy might develop severe corneal scarring following ocular infections, such events may follow their natural evolution.- - - - - - - - - - ranking = 4.903091205493E-5keywords = ocular (Clic here for more details about this article) |
7/17. Corneal surface changes in Thygeson's superficial punctate keratitis: a clinical and non-contact photomicrographic in vivo study in the human cornea.PURPOSE: To elucidate mechanisms behind the morphology of Thygeson's superficial punctate keratitis (TSPK). methods: Sixteen patients were examined with the slit lamp and photographed by non-contact photomicrography. The results were compared with morphology of epithelial keratitis in herpes simplex type 1 (HSV1), varicella zoster (VZV), and adenovirus type 8 (Ad8) infections, all previously studied by the same method, and with published histologic findings in TSPK. RESULTS: In the photographs, the corneal epithelium showed various numbers of abnormal subsurface cells measuring about 10-15 microm in diameter, present individually, in small groups, or aggregated in larger lesions (coarse lesions with the slit lamp). The surface epithelium was well preserved, except in larger lesions, which showed surface debris. The morphology was unlike HSV1 and VZV epithelial keratitis, but strongly resembled epithelial changes occurring in Ad8 infections on day 5, and later, after the onset of symptoms. CONCLUSIONS: TSPK shows a more widespread epithelial involvement than suspected with the slit lamp. Its morphology seems to reflect an action of a noxious agent targeted at the deeper epithelial layers, with the appearance of abnormal cells as a result. These might represent invading inflammatory cells, damaged intraepithelial ones, or both. The coarse lesions visualize areas of major involvement showing discernible signs of cell destruction. The similarity to Ad8 keratitis suggests that the source of the noxious agent might be located outside the cornea. The morphology, in conjunction with clinical features, is compatible with an immunologically mediated injury. The etiology remains unknown.- - - - - - - - - - ranking = 1.0239886273332keywords = keratitis, herpes simplex, simplex, herpes (Clic here for more details about this article) |
8/17. Diffuse lamellar keratitis and corneal edema associated with viral keratoconjunctivitis 2 years after laser in situ keratomileusis.A 47-year-old woman with a history of laser in situ keratomileusis (LASIK) 2 years previously for myopia and astigmatism, presented with bilateral loss of vision due to diffuse lamellar keratitis (DLK) with corneal edema in the context of a pseudomembranous viral keratoconjunctivitis. After intense and early treatment with topical corticosteroids, the corneal edema and DLK resolved and corneal transparency was achieved with complete restoration of visual acuity. This case shows that DLK may occur associated with a viral pseudomembranous keratoconjunctivitis in patients who have had LASIK. Diffuse lamellar keratitis may present up to 2 years after lamellar surgery, which would indicate that the plane created by the microkeratome at the interface may remain unhealed for at least this period of time. early diagnosis and treatment with topical corticosteroids can achieve complete resolution without visual loss.- - - - - - - - - - ranking = 0.72704878882341keywords = keratitis (Clic here for more details about this article) |
9/17. A child with vestibular neuritis. is adenovirus implicated?vertigo in children is relatively under examined in the literature. Among its causes, vestibular neuritis (VN) represents only 2% of cases, with its etiology remaining unknown. We report for the first time a 4-year-old boy with vestibular neuritis and serological results compatible with adenoviral infection. Serological diagnosis was performed on the basis of a rise and consequent normalization of complement fixation (CF) titers of the plasma antibodies. Although we were not able to detect exactly when the infection started, we were able to detect an increased level of adenovirus antibodies by CF titers, followed by a decrease (i.e. 1/16, then 1/8, then <1/4) during the recovery. This is typical of a resolving infection. Furthermore, that this increase in antibodies was specific to an adenovirus infection was suggested by the observation that we did not detect increases in antibodies to other common viruses (i.e. herpes simplex and zoster viruses, Epstein-Barr virus, cytomegalovirus, influenza and parainfluenza viruses). This allows us to exclude the chance of nonspecific antibody activation. We concluded that, although our data do not formally demonstrate an involvement of adenovirus in VN, they suggest such an involvement. This may be of interest, given that a viral etiology for VN has been proposed but not definitively proven.- - - - - - - - - - ranking = 0.054590242235318keywords = herpes simplex, simplex, herpes (Clic here for more details about this article) |
10/17. Adenovirus type 21 keratoconjunctivitis.A case of keratoconjunctivitis caused by adenovirus type 21 in london has been described. A 59-year-old woman attented hospital in August 1974 complaining of a 3-week history of redness, grittiness, watery discharge, and photophobia in her left eye and a slight upper respiratory infection. Clinical examination showed a moderate follicular conjuctivitis mainly in the lower and upper fornices, which lasted for 6 weeks. In the cornea a moderate amount of epithelial and subepithelial punctate keratitis was observed. The subepithelial opacities were coarse, discrete, and round and lasted for 4 months. The course of follicular conjunctivitis and the subepithelial punctate keratitis in this patient was similar to epidemic keratoconjunctivitis caused by adenovirus 8. A conjunctival swabbing collected from this patient was positive for adenovirus serotype 21.- - - - - - - - - - ranking = 0.24234959627447keywords = keratitis (Clic here for more details about this article) |
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