1/20. A unique case of desmoplastic ameloblastoma of the mandible: report of a case and brief review of the English language literature.A unique case of desmoplastic ameloblastoma is reported from the clinical, radiographic, and histologic viewpoints. The patient was a 56-year-old man who complained of a painless swelling on the buccal aspect of the left mandible. Periapical and panoramic radiographs revealed a rounded, slightly radiolucent area with blurred osteosclerotic margins. Occlusal radiograph and computed tomography images disclosed buccal bone expansion outlined by thinned cortices. Computed tomography images exhibited an enhanced area in the anterior portion of the lesion. Interestingly, the coronal computed tomography images revealed a close relationship between the periodontal membrane of the left mandibular second premolar and the enhanced area. biopsy specimens from the anterior portion of the lesion displayed typical histologic features of the desmoplastic variant of ameloblastoma. However, those from the posterior portion disclosed a large cystic formation. Oxytalan fibers were identified in the stromal tissue of the tumor, which suggested that the tumor arose from the epithelial rests of Malassez in the periodontal membrane of the related tooth. We also reviewed previously reported 41 cases. In 36 of 38 cases in which the location was specified, the tumor was found in the anterior to premolar region of the maxilla or mandible. A radiographic description was given in only 29 previous cases, 28 of which involved multilocular lesions. No cyst as large as the one in the present case was found among the previously reported desmoplastic ameloblastomas. Although the present case deviates from the usual desmoplastic variant of ameloblastoma in terms of locus, radiologic appearance, and cyst formation, it still meets the histologic criteria for this variant in both the stromal and epithelial components.- - - - - - - - - - ranking = 1keywords = tooth (Clic here for more details about this article) |
2/20. ameloblastoma--a diagnostic problem.A 50-year-old female was referred by her dental practitioner. She had a periapical radiolucency associated with the lower right second premolar tooth. The tooth was root treated and subsequently apicected. Tissue curetted at the time of surgery was shown to be a solid ameloblastoma which was managed initially by marginal excision. Histopathological examination of the resection specimen demonstrated tumour at the inferior margin. A segmental resection of the mandible with an immediate reconstruction using a free tissue transfer of the iliac crest was therefore performed. The case shows the need for vigilance in dealing with periapical pathology and underlines the importance of sending all tissue specimens for histopathological analysis.- - - - - - - - - - ranking = 2keywords = tooth (Clic here for more details about this article) |
3/20. Ameloblastic carcinoma ex ameloblastoma of the mandible with malignancy-associated hypercalcemia.ameloblastoma is a rare, locally destructive, benign neoplasm of the jawbones, which arises from epithelium derived from the epithelial components of the developing tooth. Ameloblastic carcinoma is the term used to designate any ameloblastoma in which there is histologic evidence of malignancy in the primary tumor, regardless of whether it has metastasized. Most ameloblastic carcinomas are presumed to have arisen de novo, with few cases of malignant transformation of ameloblastoma being apparent. hypercalcemia is the most common metabolic complication of malignancy. Although malignancy-associated hypercalcemia is often reported in association with other malignancies, it is exceedingly unusual in association with ameloblastoma, malignant ameloblastoma, or ameloblastic carcinoma. We describe a patient with multiple recurrences of ameloblastoma, with subsequent malignant transformation presenting with malignancy-associated hypercalcemia.- - - - - - - - - - ranking = 1keywords = tooth (Clic here for more details about this article) |
4/20. Desmoplastic ameloblastoma (including "hybrid" lesion of ameloblastoma). Biological profile based on 100 cases from the literature and own files.The profile of the desmoplastic ameloblastoma (DA) is presented, based on a survey of 100 cases. DA is a benign, locally invasive variant of the intraosseous, infiltrative ameloblastoma (IA). Radiologically, the DA shows ill-defined borders with a soap bubble appearance. The finding of a mixed radiolucency-radiopacity in 52% of the cases often leads to a preoperative diagnosis of a fibro-osseous lesion. association with an unerupted tooth is not a typical finding. The DA accounts for 4-13% of all ameloblastomas. The over-all average age is 42.9 years, higher for males (45.9 years) than for females (39.7 years). Thus, the DA occurs at a slightly higher age than the intraosseous ameloblastoma (37.4 years). The male/female ratio is 1:1. The maxilla/mandible ratio is 1/0.9 as opposed to 1/5.4 for the IA. Seven maxillary tumours involved an entire quadrant and 15 maxillary and mandibular tumours crossed the midline of the jaws. Pathogenetically, it seems that the DA is derived from the same sources as the IA, and extra-osseous sources do not seem to play a role. Histologically, the DA reveals the following morphological characteristics: the odontogenic epithelium occurs as irregular, stellate or follicular islands and cords, the center often appearing hypercellular with spindle-shaped or squamatoid cells. Peripheral columnar or cuboidal cells rarely reveal an ameloblast-like appearance. Thus, there are only vague tendencies to mimic a follicular ameloblastoma with acanthomatous features. The most striking feature separating the DA from IA is to be found in the tumour stroma: in DA there is extensive stromal desmoplasia with an abundance of thick collagen fibres that seem to compress the epithelial islands. Nine cases of so-called "hybrid lesion of ameloblastoma" where areas of IA coexist with areas of DA are surveyed in addition to the 100 cases of DA. No conclusions can be drawn about the biological profile of this variant due to the insufficient number of cases.- - - - - - - - - - ranking = 1keywords = tooth (Clic here for more details about this article) |
5/20. Periapical ameloblastoma--a case report.Ameloblastomas, although often benign, are locally aggressive odontogenic lesions. Presentation of this lesion as a pericoronal radiolucency associated with an impacted tooth is well documented. Presentation of this lesion as a solitary periapical radiolucency associated with a non-impacted tooth however, is rare. Periapical presentation of this lesion may confuse practitioners.- - - - - - - - - - ranking = 2keywords = tooth (Clic here for more details about this article) |
6/20. Ameloblastic fibroma of the mandible. Report of two cases.The ameloblastic fibroma (AF)-ameloblastic fibro-odontoma (AFO), is an uncommon benign mixed odontogenic tumor (epithelial and mesenchymal), that represents the 2% of all odontogenic tumors. It usually appears in the mandible and in the posterior segments of young patients without gender predilection, and sometimes is associated with an impacted tooth. The classification of the WHO includes it in the subtype of odontogenic tumors with a defined histologic features. The AF and the AFO are considered as an unique entity as they are variations of the same tumor, only distinct for the presence of an odontoma in the case of the AFO. Surgical conservative treatment with excision followed by curettage seems to be the most appropriate therapeutic option. The objective of this paper is to report two cases of this tumor, to make a brief review of the literature and its differential diagnosis, to analyse its clinical and histologic features and the therapeutic option.- - - - - - - - - - ranking = 1keywords = tooth (Clic here for more details about this article) |
7/20. Ameloblastic carcinoma: case report and literature review.Ameloblastic carcinoma is a rare malignant lesion with characteristic histologic features and behaviour that dictates a more aggressive surgical approach than that of a simple ameloblastoma. However, reliable evidence of its biologic activity is currently unavailable due to the scarcity of well-documented cases. It occurs primarily in the mandible in a wide range of age groups; no sex or race predilection has been noted. It may present as a cystic lesion with benign clinical features or as a large tissue mass with ulceration, significant bone resorption and tooth mobility. Because the lesion is usually found unexpectedly after an incisional biopsy or the removal of a cyst, a guide to differential diagnosis is not usually useful. The identifying features of ameloblastic carcinoma must be known and recognized by dental practitioners. Our understanding of the histologic features of ameloblastic carcinoma is somewhat vague. The tumour cells resemble the cells seen in ameloblastoma, but they show cytologic atypia. Moreover, they lack the characteristic arrangement seen in ameloblastoma. The clinical course of ameloblastic carcinoma is typically aggressive, with extensive local destruction. Direct extension of the tumour, lymph node involvement and metastasis to various sites (frequently the lung) have been reported. Wide local excision is the treatment of choice. Regional lymph node dissection should be considered and performed selectively. radiotherapy and chemotherapy seem to be of limited value for the treatment of ameloblastic carcinomas. At the moment, there are too few reported cases to make a definite recommendation regarding treatment. Close periodic reassessment of the patient is mandatory.- - - - - - - - - - ranking = 1keywords = tooth (Clic here for more details about this article) |
8/20. Peripheral ameloblastoma. A case report and review of the literature.Peripheral ameloblastoma is a benign odontogenic tumor with the same histological characteristics as the centrally located ameloblastoma, but appearing in the gingiva and mucosa of the tooth-bearing area of the jaws. A review is presented of 53 cases: 45 being reported as peripheral ameloblastoma and 8 as basal cell carcinoma of the gingiva, including the case presented. Based on the review it is recommended to treat this lesion by local excision including a small margin of healthy tissue. Local recurrence is unlikely, unless incomplete removal is performed.- - - - - - - - - - ranking = 1keywords = tooth (Clic here for more details about this article) |
9/20. Peripheral ameloblastoma: a case report.Peripheral ameloblastoma is a rare odontogenic soft tissue tumor, derived from epithelial and/or mesenchymal elements being part of the tooth-forming apparatus. The lesion responses for approximately 1% to 5% of all cases of ameloblastoma affecting alveolar mucosa and gingiva occur, mainly, in the middle age. This article describes a case of peripheral ameloblastoma involving a 20-year-old male located in the (upper/lower, vestibular/buccal) gingiva. After the case presentation, clinical and microscopic findings are discussed.- - - - - - - - - - ranking = 1keywords = tooth (Clic here for more details about this article) |
10/20. Unicystic ameloblastoma: a possible pitfall in periapical diagnosis.AIM: To report a clinical case of unicystic ameloblastoma previously misdiagnosed as radicular cyst. SUMMARY: A 49-year-old white male was referred to a private practitioner complaining of an asymptomatic bony hard swelling of the left posterior mandible. The patient's dental history indicated that his left mandibular first molar had been extracted approximately 10 years previously. At that time, preoperative radiographic examination demonstrated a radiolucent area of 1.5 cm diameter with well-defined margins involving the distal root of tooth 36. The lesion was diagnosed as cystic and surgery for its removal was advised, but not performed. At presentation, radiography demonstrated a well-defined 3 cm diameter radiolucency extending from the second premolar to the second molar. The lesion was enucleated and histopathological examination confirmed a diagnosis of unicystic ameloblastoma. KEY learning POINTS: *Despite a clinical diagnosis of periapical disease of endodontic origin, a nonendodontic lesion may be present. *Unicystic ameloblastoma located on the periapical area of a tooth can lead to a pulp-periapical misdiagnosis, and should be considered in differential diagnosis. *All tissue specimens recovered in apical surgery should be submitted to histopathological analysis.- - - - - - - - - - ranking = 2keywords = tooth (Clic here for more details about this article) |
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