1/23. Radical excision of multifocal anal intraepithelial neoplasia: report of a case.PURPOSE: The aim of this study was to describe the technique of radical excision of multifocal anal intraepithelial neoplasia and discuss controversial issues surrounding the management of this condition. METHOD: We describe the case of a 31-year-old female with previous vulval warts, vulval squamous carcinoma, and recent immunosuppression who had widespread anal intraepithelial neoplasia excised, and the resulting defect was split-skin grafted, including the anal canal. RESULTS: Excision and split-skin grafting was successful in removing the disease and left a satisfactory cosmetic and functional result. CONCLUSION: Diffuse, high-grade, anal intraepithelial neoplasia is rare. Excision of these lesions remains controversial but may be the best option.- - - - - - - - - - ranking = 1keywords = wart (Clic here for more details about this article) |
2/23. Anal verrucous carcinoma and penile condylomata acuminata.A 50-year-old man presented with recurrent tumorous lesions on the penis and the anal region. The anal lesion was histologically diagnosed as verrucous carcinoma (VC) and the penile lesions were in line with condylomata acuminata. Samples taken from tumors of both sites were human papillomavirus (HPV) dna positive. Two of them taken from the penis and the perianal region scored HPV dna 6 positive by using polymerase chain reaction and the Southern blot method. Treatment of both VC and condylomata acuminata consisted in surgery and adjuvant immune therapy. Neither tumor recurrence nor metastases occurred up until 6 months after therapy.- - - - - - - - - - ranking = 313.92118810119keywords = condylomata acuminata, condylomata, acuminata (Clic here for more details about this article) |
3/23. Successful treatment of anogenital bowen's disease with the immunomodulator imiquimod, and monitoring of therapy by dna image cytometry.Imiquimod (Aldara, 3M) is an immune response modifier used for the treatment of anogenital warts. We report a 55-year-old non-immunocompromised woman with extensive, human papillomavirus (HPV) 16-positive anogenital bowen's disease. After 5 months of local treatment with imiquimod, the lesions completely regressed clinically and histologically, and HPV 16 dna was no longer detectable. Moreover, dna image cytometry revealed dna aneuploidy (an indicator of prospective malignancy) in pretreatment samples but not in post-treatment samples. Therefore, imiquimod might be a treatment option for bowen's disease, particularly in patients where other treatment modalities such as surgery are contraindicated.- - - - - - - - - - ranking = 1keywords = wart (Clic here for more details about this article) |
4/23. Children with condylomata acuminata.BACKGROUND. The modes of transmission of genital human papillomavirus (HPV) infection in children are controversial. Studies have varied in reporting suspicion of sexual abuse in children with condylomata acuminata from zero to 90.9%. Possible modes of transmission include sexual, from mother to infant in utero, passage through an infected birth canal, infection of a nongenital type virus to the genital area, and nonsexual acquisition from a fomite. methods. Seven children, ranging in age from 2 to 12 years, who had genital HPV infections were assessed for sexual abuse. An interview with each child was conducted and an examination with a colposcope of the external genitalia was performed. A shave biopsy of a representative genital lesion was obtained. The tissue was sent for HPV typing. RESULTS. Six of the children had perianal warts; the seventh had a labial lesion. Five of the children (71%) had been sexually abused as determined by the history, physical examination, or an investigation by child Protective Services. Five had HPV type 6 or 11, one had HPV type 16 or 18, and one had a novel HPV type. CONCLUSIONS. Genital types of HPV (6 or 11, 16 or 18, and others) should alert the family physician to proceed with a careful assessment for sexual abuse. This study supports the findings of other reports that genital HPV infection can be the result of sexual abuse and points out the usefulness of HPV typing.- - - - - - - - - - ranking = 262.60099008433keywords = condylomata acuminata, condylomata, acuminata, wart (Clic here for more details about this article) |
5/23. Human papillomavirus type 16 in a homosexual man. association with perianal carcinoma in situ and condyloma acuminatum.BACKGROUND--The association of anal carcinoma with human papillomavirus (HPV) type 16 infection is well documented. Anal carcinoma is also frequently associated with a history of anogenital condylomata. More than 90% of anogenital condylomata contain HPV type 6 or 11. It is rare for a condylomatous lesion to contain HPV 16. We report the unusual case of a homosexual man, testing positively for human immunodeficiency virus, with carcinoma in situ evolving within perianal condylomata infected with HPV 16. OBSERVATIONS--Microscopic examination of tissue specimens from ulcerated verrucous lesions on the perianal mucosa revealed changes of classic condylomata acuminata with contiguous focal squamous cell carcinoma in situ. Testing for HPV dna by in situ hybridization identified HPV 16 in both the condylomatous and carcinoma in situ areas. CONCLUSIONS--The association of HPV 16-infected condylomata and adjacent carcinoma in situ implies that cutaneous genital condylomata may progress to high-grade lesions. Given that homosexual men are at high risk for perianal carcinomas, HPV typing of perianal condylomata specimens may help identify immunocompromised patients who are at risk for the development of carcinomas.- - - - - - - - - - ranking = 87.982178030483keywords = condylomata acuminata, condylomata, acuminata (Clic here for more details about this article) |
6/23. Synchronous anal and penile cancers.Malignancies of the anogenital region have similar etiology, including viral infections, sexual habits, social and educational factors. condylomata acuminata represent precancerous lesions. In the available literature, we found no cases of synchronous cancers of anus and penis reported. We report a case of synchronous cancer of the penile foreskin and cancer of the anus in a 36 year-old man. The microscopic diagnosis of the anal lesion was squamous cell cancer, basaloid type. The penile lesion was squamous cell cancer, keratinizing type. Both cancers presented with the in situ component. Immunohistochemical staining (MIB-1) and histological features (koilocytosis, acanthosis and dyskeratosis) indirectly confirmed the past viral infection. Numerous etiological similarities in anogenital cancers entail careful clinical inspection in patients with a malignant lesion in this region and suggest searching for possible other concomitant cancers or precancerous lesions.- - - - - - - - - - ranking = 3.7071399569853keywords = acuminata (Clic here for more details about this article) |
7/23. buschke-lowenstein tumor in childhood: a case report.buschke-lowenstein tumor or giant condyloma is a warty verrucous lesion, characterized by slow growth, locally infiltrating and disfiguring lesions. Despite its benign histological appearance and low risk of metastasis, buschke-lowenstein tumor is an intermediate lesion between condyloma acuminatum and verrucous carcinoma. It has been linked to human papilloma virus, mainly subtypes 6 and 11. Other factors implicated in this disease include poor hygiene, chronic irritation, promiscuity, and cellular immunocompromised states. It rarely occurs in children. The first line of treatment is radical surgical excision with or without adjuvant chemotherapy. We report the case of a 12-year-old girl with a giant perianal condyloma that was treated with surgical excision and a 6-week course of 5-fluorouracil beginning 6 weeks after surgery, with excellent functional and cosmetic results.- - - - - - - - - - ranking = 1keywords = wart (Clic here for more details about this article) |
8/23. A patient with simultaneous absence of "classical" natural killer cells (CD3-, CD16 , and NKH1 ) and expansion of CD3 , CD4-, CD8-, NKH1 subset.The clinical manifestations of putative natural killer (NK) cell deficiency are not well-known but theoretically should include recurrent tumors and systemic viral infections. In this article, we discuss a patient with recurrent condylomata, vulvar and cervical carcinoma in situ, pulmonary infiltrates of unknown significance, and a hypercoagulable state. This patient has a dramatic persistent deficiency in her circulating "classic" NK cells (CD3-, CD16 , NKH1 ) and a simultaneous persistent expansion of a normally minor lymphocyte cell subset (CD3 , CD4-, CD8-, NKH1 ) that does not express the alpha beta heterodimer of the T cell receptor. T-lymphocyte function, as measured by mitogen and alloantigen responsiveness in vitro, was normal. The coexistence of this particular clinical complex with this unusual set of laboratory abnormalities tends to emphasize our meager understanding of the biologic role of NK cells. At the very least, these findings suggest that the clinical manifestations of NK cell deficiency need not be dominated by disseminated systemic viral infections and that perhaps there should be a higher index of suspicion for the scrutinization of NK cell function.- - - - - - - - - - ranking = 5.943663335603keywords = condylomata (Clic here for more details about this article) |
9/23. Squamous carcinoma of the anus in young homosexual men with T helper cell depletion.Two cases of squamous carcinoma of the anus in white homosexual men aged 36 and 47 years are reported, each with a short history of rapidly enlarging perianal lesions. Immunological studies showed that both men had pronounced T helper lymphocyte depletion, and antibody to human T cell lymphotropic virus type III (HTLV-III) was detected in both patients. In addition one patient had a long history of wart virus infection of the anal canal. The diminished cellular immunity associated with HTLV-III may have been responsible for the development of the squamous carcinoma, either directly or by its association with human papilloma virus infection.- - - - - - - - - - ranking = 1keywords = wart (Clic here for more details about this article) |
10/23. Successive urinary papillomavirus excretion, condylomata acuminata and urogenital epithelial malignant disease after renal transplantation.Of 3 renal allograft recipients who were found to excrete papillomavirus in the urine, 1 has since developed a condyloma, 1 a condyloma and a keratinizing squamous carcinoma and 1 a transitional cell carcinoma. peroxidase-antiperoxidase staining has confirmed the presence of papillomavirus antigen in the condylomas. The significance of these findings is discussed.- - - - - - - - - - ranking = 209.28079206746keywords = condylomata acuminata, condylomata, acuminata (Clic here for more details about this article) |
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