1/5. Localized argyria with pseudo-ochronosis.BACKGROUND: Localized argyria is uncommon and presents clinically as asymptomatic slate gray macules or blue macules resembling blue nevi. Its histopathologic features are usually similar to those of generalized argyria in which silver granules are found most commonly around the eccrine glands, in the walls of blood vessels, and along elastic fibers. Ochre swollen homogenized collagen bundles resembling ochronosis have not been previously described. OBJECTIVE: The purpose of this study is to report a series of 5 patients with localized argyria with the histologic feature of "pseudo-ochronosis." In one patient, biopsy was performed on 2 distinct lesions. methods: All patients underwent skin biopsies for light microscopy and darkfield microscopy. In two patients, the biopsy specimens were analyzed with a mass spectrophotometer; scanning electron microscopy and energy-dispersive x-ray analysis were performed. In one patient, the biopsy specimen was decolorized with 1% potassium ferricyanide in 20% sodium thiosulfate. RESULTS: All 5 patients presented with the typical clinical and histologic features of localized argyria. Ochre swollen and homogenized collagen bundles were seen in all cases. In addition, light microscopy in 4 cases revealed an ellipsoid black globule within a zone of collagen degeneration. CONCLUSION: The histologic features of localized argyria include swollen and homogenized collagen bundles resembling ochronosis, "pseudo-ochronosis," which may be more common than previously recognized.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
2/5. Localized argyria 20-years after embedding of acupuncture needles.We report a 66-year-old woman with localized argyria caused by embedding of acupuncture needles. Ten years after she had received acupuncture, she noticed two asymptomatic bluish macules on her right arm. A biopsied specimen from the macule revealed many brownish-black granules mainly located around the sweat glands and the blood vessels in the dermis. The X-ray examination of the extremities revealed numerous needle-like fragments around her extremities. "Embedding of needles" induces some serious adverse events. We should know the adverse events for the safety and health of patients.- - - - - - - - - - ranking = 642.65422966949keywords = sweat gland, gland (Clic here for more details about this article) |
3/5. Blue macules of localized argyria caused by implanted acupuncture needles. Electron microscopy and roentgenographic microanalysis of deposited metal.acupuncture needles implanted in the skin for more than ten years caused peculiar bluish macules, each of which clinically resembled a blue nevus in the extremities of a 63-year-old Japanese woman. Histologically, the involved skin showed deposition of fine brownish granules in the basement membrane of the eccrine sweat glands, on the inner surface of the blood vessel walls, and along elastic fibers of the superficial dermis in addition to sparse deposits noted throughout the dermis. Electron microscopy revealed deposits of electron-dense particles on the basal lamina of the secretory coils of the eccrine sweat glands, below the basal lamina of the dermoepidermal junction, and on elastic fibers. Roentgenographic microanalysis of the involved skin demonstrated that most of the granules consisted of silver and chloride; silver was a major component in the removed needles.- - - - - - - - - - ranking = 1285.308459339keywords = sweat gland, gland (Clic here for more details about this article) |
4/5. Generalized argyria after habitual use of AgNO3.Generalized argyria, the systemic dissemination and tissue deposition of silver-containing particles, is characterized by slate gray discoloration of skin, most pronounced in sun exposed areas. A 33-year-old woman visited our dermatologic clinic complaining of frequent oral ulceration for 10 years and generalized discoloration of her skin for 5 years. She had had her tongue painted with silver nitrate repeatedly 6 years ago for the treatment of oral ulcers. physical examination showed slate gray discoloration of her skin, most pronounced on the face and neck. The oral mucosa, tongue, sclera, and conjunctiva also had a slightly blue-gray discoloration. biopsy specimens from the oral mucosa and forearm revealed small brown-black granules scattered in the dermis and basal lamina of eccrine sweat glands, blood vessels, and hair follicles under the light microscope. Tiny black granules were most numerous in the basal laminae of vessels in electron microscopic observation. Energy dispersive X-ray microanalysis (EDXA) confirmed that many of the granules contained silver.- - - - - - - - - - ranking = 642.65422966949keywords = sweat gland, gland (Clic here for more details about this article) |
5/5. Human generalized argyria: a submicroscopic and X-ray spectroscopic study.A 58-year-old man presented with a slate-gray discoloration of the skin. The patient had no medical complaint apart from the increasing cosmetic disability. He gave no drug history and denied professional exposure to chemical compounds. General medical examination was noncontributory; routine laboratory data were within the normal range. light microscopy revealed the presence of numerous, small, pigmented particles at the dermal level. The submicroscopic investigation showed that the granules were deeply electron dense, had an irregular polycyclic contour, and varied in size between 100 and 600 nm. They were predominantly located in relation to the basal laminae of the epidermis and the cutaneous appendages, and in the dermal elastic fibers. In addition, the authors were able to document the presence of silver particles lying free in the cytoplasm of both epithelial cells of the secretory segment of eccrine sweat glands and mastcells, findings that have never been reported so far. X-ray spectroscopy documented that the electron-opaque particles contained silver, with some differences in the elemental composition of the granules, according to their location. These novel findings expand the knowledge of the various mechanisms of interaction of silver with the cellular and extracellular environment and allow some speculations about possible mechanisms of silver detoxification.- - - - - - - - - - ranking = 642.65422966949keywords = sweat gland, gland (Clic here for more details about this article) |