1/11. Subcorneal pustular dermatosis-type IgA pemphigus induced by thiol drugs.We report a case of subcorneal pustular dermatosis (SPD)-type IgA pemphigus arising in a 49 year-old woman with rheumatoid arthritis who had been treated with chrysotherapy. Scaly erythemic plaques containing vesicles and pustules occurred on her chest and abdomen during the course of anti-rheumatic treatments using prednisolone at 11 mg/day and thiol compounds (bucillamine and gold sodium thiomalate). Histological investigations revealed subcorneal pustules containing many neutrophils and a few acantholytic cells, and intercellular IgA deposits at the upper epidermis of the eruptions without any other immunoglobulins and complement component C3. Circulating IgA antibodies directed against intercellular spaces of the epidermis were found by prolonged incubation of normal skin specimens in medium containing 20% patient's serum in an explant culture, although standard indirect immunofluorescence for IgA antibodies was negative. The eruptions were treated successfully with prednisolone, 30 mg/day, dapsone, 50 mg/day, and discontinuance of the thiol compound. In addition to the coexistent rheumatoid arthritis, both thiol compounds might have been responsible for the development of the eruptions.- - - - - - - - - - ranking = 1keywords = dermatosis (Clic here for more details about this article) |
2/11. colchicine treatment in a patient with neutrophilic dermatosis associated with rheumatoid arthritis.Neutrophilic dermatoses (ND) are characterized by epidermal and dermal infiltrates of polymorphonuclear leukocytes (PMN), without any infectious or other detectable agents as a cause. We describe a case of ND, which very rapidly improved upon colchicine treatment. The patient was a 67-year-old female with an 8-month history of dusky-red, tender, swollen plaques and nodules with superimposed vesicles and bullae on the buttocks, hands, and ankles associated with rheumatoid arthritis. The diagnosis of ND was made on the basis of the clinical and histopathological features of the skin lesions. She was treated with 0.6 mg of oral colchicine twice daily. Within one week, the erythematous plaques and arthralgia began to recede and disappeared within four weeks. In our case, colchicine seemed to improve the signs and symptoms of ND and appeared to be more effective than the other drugs we had used.- - - - - - - - - - ranking = 0.8keywords = dermatosis (Clic here for more details about this article) |
3/11. Sweet's syndrome with arthritis and vasculitis.Acute febrile neutrophilic dermatosis or Sweet's syndrome is a rare disease. We describe a patient with oligoarthritis, increased liver enzymes and vasculitis. One year later the patient is free of symptoms. Diseases mimicking Sweet's syndrome have been excluded.- - - - - - - - - - ranking = 0.2keywords = dermatosis (Clic here for more details about this article) |
4/11. A bullous neutrophilic dermatosis in a patient with severe rheumatoid arthritis and monoclonal IgA gammopathy.A 35-year-old man presented with a 2-month history of itchy grouped vesiculobullae with crusted papules and confluent plaques, distributed symmetrically on the thighs, knees, and elbows. The man had experienced severe disabling seropositive rheumatoid arthritis for 18 years previously. Histologically, subepidermal vesicles were noted, and a dense, diffuse neutrophilic infiltration of the dermis. Direct immunofluorescence studies did not detect IgA deposits. The patient responded well to dapsone (100 mg/d) but not to systemic steroids. This patient's eruption might have been an unusual manifestation of rheumatoid neutrophilic dermatitis.- - - - - - - - - - ranking = 0.8keywords = dermatosis (Clic here for more details about this article) |
5/11. Rheumatoid neutrophilic dermatitis.Rheumatoid neutrophilic dermatitis (RND) is an infrequent cutaneous manifestation of rheumatoid arthritis (RA). This condition is seen in patients who are both positive and negative for a circulating rheumatoid factor. Histologically, it presents with a neutrophilic dermatosis, characterized by a heavy dermal infiltrate of neutrophils with variable degrees of leukocytoclasis but no vasculitis. We describe the case of a young female with seronegative RA who had concomitant lesions of RND over both elbows. Her lesions appeared as nodules, but RND has been reported as papules and plaques, sometimes with an urticarialike appearance or ulcerations. They are often symmetric. The possibility of RND should be considered in the differential of unusual skin lesions in all patients with RA, as the presentation is quite varied.- - - - - - - - - - ranking = 0.2keywords = dermatosis (Clic here for more details about this article) |
6/11. linear iga bullous dermatosis associated with rheumatoid arthritis.A case of linear iga bullous dermatosis associated with rheumatoid arthritis is described. The eruption consisted of multiple irregular erythematous plaques and small numbers of tense vesicles mainly on the trunk. An immunofluorescence study showed linear IgA and IgG deposition along the basement membrane zone, whereas C3 deposition was not found. IgA or IgG anti-basement membrane zone antibody was not detected in the serum. Treatment with dapsone resulted in good control of the eruption. Coexistence of linear iga bullous dermatosis and rheumatoid arthritis has not been reported previously.- - - - - - - - - - ranking = 1.2keywords = dermatosis (Clic here for more details about this article) |
7/11. Subcorneal pustular dermatosis associated with rheumatoid arthritis and raised IgA: simultaneous remission of skin and joint involvements with dapsone treatment.A 44 year old white woman with rheumatoid arthritis for 19 years developed subcorneal pustular dermatosis. She had increased polyclonal IgA and IgA rheumatoid factor. After 4 months' treatment with dapsone 100 mg daily the patient had neither skin lesions nor active joint disease.- - - - - - - - - - ranking = 1keywords = dermatosis (Clic here for more details about this article) |
8/11. Acute febrile neutrophilic dermatosis (Sweet's syndrome). association with rheumatoid vasculitis.A 58-year-old woman suffering from rheumatoid arthritis complicated by a leukocytoclastic vasculitis had an acute febrile neutrophilic dermatosis (Sweet's syndrome) develop immediately after worsening of her arthritic condition. This association supports the hypothesis that immunologic abnormality is involved in the pathogenesis of Sweet's syndrome and raises the question of a possible common pathogenic pathway between neutrophilic dermatoses and leukocytoclastic vasculitis.- - - - - - - - - - ranking = 1keywords = dermatosis (Clic here for more details about this article) |
9/11. Subcorneal pustular dermatosis and crippling arthritis.A 25-year-old woman has suffered with subcorneal pustular dermatosis and a rheumatoid-like arthritis for the past 11 years. Both her skin lesions and arthralgia have abated with institution of dapsone administration and have worsened with interruption or reduction of the dose. The coexistence of arthritis and subcorneal pustular dermatosis and the response of both to therapy suggest a probable association.- - - - - - - - - - ranking = 1.2keywords = dermatosis (Clic here for more details about this article) |
10/11. Sweet's syndrome associated with rheumatoid arthritis.A case of Sweet's syndrome (acute febrile neutrophilic dermatosis) is reported in a patient with long-standing rheumatoid arthritis. Although Sweet's syndrome has been described in association with leukemias, other malignancies, and a variety of inflammatory disorders, it has not been associated with rheumatoid arthritis. Sweet's syndrome is reviewed with regard to pathogenesis and associated diseases.- - - - - - - - - - ranking = 0.2keywords = dermatosis (Clic here for more details about this article) |
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