1/37. "Ankylosing spondylitis" without sacroiliitis in a woman without the HLA B27 antigen.An elderly woman with otherwise typical ankylosing spondylitis for 45 years lacked radiologic evidence of sacroiliitis and the HLA B27 antigen. The illness was complicated by renal tuberculosis requiring a left nephrectomy 23 years after the onset of low back pain, and 20 years after an episode of severe iritis. After the eradication of the tuberculosis by surgery and chemotherapy, she has continued to have symptomatic spondylitis. The case seems to be an exception to the rule that sacroiliitis is a sine qua non for ankylosing spondylitis. women with ankylosing spondylitis tend to have milder disease with an apparently lower frequency of roentgenographic changes in sacroiliac joints.- - - - - - - - - - ranking = 1keywords = spondylitis (Clic here for more details about this article) |
2/37. arthritis in myasthenia gravis.Seven patients with myasthenia gravis developed clinical signs of arthropathy. In two patients, the symptoms were due to a deforming rheumatoid arthritis and the myasthenic symptoms appeared as a transitory phase during the course of the disease. Muscle antibodies of IgG class were demonstrated with sera from both patients. Autoreactivity between muscle antibodies and rheumatoid factor was detected in one patient. Both patients died from sudden cardiac failure. Necropsy was performed in one and revealed a spotty myocardial necrosis. One patient had juvenile rheumatoid arthritis. Two patients had mild articular symptoms with indices of multivisceral disease and serological findings indicating a systemic lupus erythematous. One patient had classical ankylosing spondylitis, and one, unspecified arthropathy.- - - - - - - - - - ranking = 0.125keywords = spondylitis (Clic here for more details about this article) |
3/37. Repeated cyclosporine therapy of peripheral arthritis associated with ankylosing spondylitis.BACKGROUND: A case history of a patient with ankylosing spondylitis and peripheral arthritis unresponsive to the conventional drug therapy, but successfully controlled by the use of cyclosporin. MATERIAL AND methods: In a 68 years old female patient with a 36 years history of typical ankylosing spondylitis a peripheral polyarthritis (hands, feet, wrists, and knees) developed. The patient did not suffer any other disease known to cause secondary spondylitis (psoriasis, inflammatory, bowel, disease). After the unsuccessful use of non-steroidal antiinflammatory drugs a combination therapy with cyclosporin (4 mg/kg/day) and azapropazone (300 mg t.i.d.) was introduced. RESULTS: Clinical improvement was achieved after 6 months of combined therapy, the polyarthritis completely resolved after one year. Therefore cyclosporin was discontinued. After one year the polyarthritis reappeared therefore the cyclosporin therapy was reinstituted with success. CONCLUSION: Cyclosporin has proved consistently effective in our case to control the peripheral arthritis associated with ankylosing spondylitis.- - - - - - - - - - ranking = 1keywords = spondylitis (Clic here for more details about this article) |
4/37. Juvenile Reiter's syndrome: a case report.Reiter's syndrome (RS) is uncommon in children, and the classic triad manifestations of RS usually do not occur simultaneously in children. It is often clinically confused with other childhood illnesses. We report a case of RS in a 7-year-old boy with a family history of ankylosing spondylitis. He had developed intermittent arthralgia of the right knee for about 6 months and occasional bilateral eye pain for several months prior to admission. In the 5 days before admission, he developed multiple oral ulcers, weight loss from 25 to 22 kg and fever. physical examination showed injected bilateral conjunctivae and the right knee joint with swelling, local warmth, and tenderness over the patellar ligament. Laboratory results revealed positive histocompatibility antigen-B27 (HLA-B27), negative rheumatoid factor (RF) and antinuclear antibody (ANA) and normal urinalysis. RS was diagnosed based on the findings of both arthritis and conjunctivitis. The arthritis was treated with acetaminophen and naproxen. In conclusion, juvenile RS should be considered in children with arthritis and conjunctivitis, positive HLA-B27, negative RF and ANA and a family history of related diseases.- - - - - - - - - - ranking = 0.125keywords = spondylitis (Clic here for more details about this article) |
5/37. DISH and ankylosing spondylitis. Case report and review of the literature.Ankylosing spondylitis (A.Sp.) and diffuse idiopatic skeletal hyperostosis (DISH), represent the most common inflammatory and degenerative enthesopathies, respectively. Despite their rather frequent occurrence in the rheumatic disease care setting, few case reports of their simultaneous presence in the same patient have appeared in the literature. We describe here a further observation and review the rheumatologic literature.- - - - - - - - - - ranking = 0.625keywords = spondylitis (Clic here for more details about this article) |
6/37. Selective iga deficiency and spondyloarthropathy: a distinct disease?A woman with selective iga deficiency and severe ankylosing spondylitis (AS), complicated by intractable peripheral arthritis, is described. Three previous cases of selective iga deficiency and AS have been reported, all of whom had severe AS. It is suggested that selective iga deficiency is a poor prognostic factor in AS and therefore warrants further investigation to determine the clinical course of such patients.- - - - - - - - - - ranking = 0.125keywords = spondylitis (Clic here for more details about this article) |
7/37. Ankylosing spondylitis of childhood onset.Ankylosing spondylitis begins in childhood in a significant number of patients. The disease may begin in one of two ways: with early hip girdle and low back complaints, or with peripheral arthritis affecting a few large joints. Ankylosing spondylitis should be suspected in seronegative boys over the age of 8 years who have pauciarticular arthritis, particularly if there is associated hip girdle involvement. Early recognition of ankylosing spondylitis may be helpful in appropriate therapy and followup of patients.- - - - - - - - - - ranking = 0.875keywords = spondylitis (Clic here for more details about this article) |
8/37. Late onset peripheral spondyloarthropathy.After studying 10 cases, we describe a form of late onset, B27 related disease. The patients were men over 50 with minimal involvement of the axial skeleton, mild oligoarthritis of the lower limbs, paucicellular joint fluids and fibrosis on synovial biopsy. In contrast, they appeared severely ill with erythrocyte sedimentation rates elevated and a large amount of pitting edema. Their response to nonsteroidal antiinflammatory drugs was poor. The disease did not abate for from one to several years. Five patients later presented bilateral sacroiliitis and 4 of these developed ankylosing spondylitis (AS). This clinical presentation of AS may owe its distinctive features to its late onsets.- - - - - - - - - - ranking = 0.125keywords = spondylitis (Clic here for more details about this article) |
9/37. Takayasu's disease and bilateral sacroiliitis.A young woman, with HLA B27 negative bilateral sacroiliitis and subsequent Takayasu's disease is described. It has been previously suggested that there is an association between Takayasu's disease and ankylosing spondylitis. We discuss and dispute this association.- - - - - - - - - - ranking = 0.125keywords = spondylitis (Clic here for more details about this article) |
10/37. Treatment of the seronegative spondyloarthropathies with sulfasalazine.Three patients with reactive arthritis and 2 with ankylosing spondylitis resistant to therapy with nonsteroidal antiinflammatory drugs were treated with enteric coated sulfasalazine in an open trial. Significant toxicity was not observed; 1 patient discontinued sulfasalazine because of gastrointestinal symptoms. As a group, statistically significant improvement was observed in 50 foot walk time, morning stiffness, and hemoglobin concentration. One patient went into complete clinical remission, 2 improved, 1 showed no change, and 1 worsened. Asymptomatic colonic inflammation was found in each of 4 patients examined before beginning therapy. Changes in bowel pathology did not parallel changes in joint symptoms. sulfasalazine may be a safe and useful therapeutic modality in patients with chronic reactive arthritis or ankylosing spondylitis.- - - - - - - - - - ranking = 0.25keywords = spondylitis (Clic here for more details about this article) |
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