1/3. Case report: successful interdisciplinary treatment of cerebrally disseminated invasive pulmonal aspergillosis in a child with acute myeloid leukemia.invasive pulmonary aspergillosis (IPA) is a life-threatening infection in immunocompromised patients. mortality rates of cerebrally disseminated IPA approach 100%. We report on a case of a 9-year-old girl with acute myeloid leukemia, who acquired cerebrally disseminated IPA during chemotherapy-induced leukopenia. Longtime survival was achieved by left pneumonectomy and neurosurgical resection of the intracerebral lesion combined with systemic application of itraconazole and liposomal amphotericin b. A review of literature revealed 7 other cases of cerebrally disseminated IPA with survival of more than 12 months.- - - - - - - - - - ranking = 1keywords = leukemia (Clic here for more details about this article) |
2/3. Aspergillary bronchopneumonia: an unusual cause of atelectasis and asphyxia in a leukemic patient.A 22-year-old man in his first relapse of T-acute lymphoblastic leukemia developed fever and a pulmonary infiltrate after 23 days of granulocytopenia. Although having been under amphotericin b for 10 days, productive purulent cough ensued, with right lobe atelectasis and acute ventilatory failure that resolved after the elimination of a thick gelatinous bronchial plug. sputum cultures yielded candida albicans and staphylococcus epidermidis, and microscopic examination of the sputum plug disclosed aspergillus hyphae. The patient died 9 days after, of a disseminated aspergillus infection, confirmed by necropsy.- - - - - - - - - - ranking = 0.2keywords = leukemia (Clic here for more details about this article) |
3/3. Unusual invasive bronchial aspergillosis in a patient with acute lymphoblastic leukemia.Invasive tracheobronchial aspergillosis is an uncommon form of aspergillus lung infection observed in immunocompromised patients. A 43-year-old patient diagnosed with acute lymphoblastic leukemia presented prolonged fever and hemoptysis during remission induction chemotherapy. The bronchoscopic examination showed pale mucosa with multiple raised white-colored nodules of 3 to 5 millimeters in diameter in all the bronchi. hyphae of aspergillus sp were observed in the biopsy of one of the nodules and in the examination of the bronchoalveolar lavage. Despite amphotericin b therapy, the patient developed bilateral necrotizing pneumonia and multiple abscesses in the brain and in the thyroid gland, and died. From a review of the literature in the medline database, four similar cases (two in AIDS patients, one in lymphoma and the remaining case in an acute myeloid leukemia patient) have been reported.- - - - - - - - - - ranking = 1.2keywords = leukemia (Clic here for more details about this article) |