1/8. Hypergammaglobulinaemic purpura presenting as reticulate purpura.Hypergammaglobulinaemic purpura, first described by Waldenstrom, is a rare skin disease. The essential features are the presence of purpura with polyclonal hypergammaglobulinaemia. We describe a case of hypergammaglobulinaemic purpura occurring in a Chinese man with reticulate purpura and haemorrhagic blisters.- - - - - - - - - - ranking = 1keywords = purpura (Clic here for more details about this article) |
2/8. Papular-purpuric gloves-and-socks syndrome with bloody bullae.Papular-purpuric gloves-and-socks syndrome (PPGSS) is a disease characterized by itchy, painful acral erythema with edema, confluent papules, and purpura in a gloves-and-socks distribution and is associated with fever and mucosal lesions. parvovirus B19 and other viral infections have been proven to be causative agents of this syndrome. Its histological findings have been the non-specific ones of interface dermatitis. Here, we report a case of PPGSS in a 44-year-old man that we believe to be the first such case in japan. He developed, within one day, a painful edematous eruption with confluent papules and purpura on his hands and feet accompanied by high fever. A unique clinical manifestation in this case was multiple bloody bullae on the toes, which have not been previously described. Serological tests were negative for parvovirus B19, cytomegalovirus, and measles virus.- - - - - - - - - - ranking = 0.16666666666667keywords = purpura (Clic here for more details about this article) |
3/8. Henoch-Schonlein purpura with hemorrhagic bullae in children: report of two cases.Henoch-Schonlein purpura (HSP) is the most common form of acute vasculitis primarily affecting children. Clinical features include skin rashes, arthritis, abdominal pain and nephritis. skin biopsy on immunofluorescence often reveals granular depositions of immunoglobulin a (IgA) and C3 within the walls of the dermal vessels as well as in the connective tissue of the upper dermis. The diversity of skin rashes produces confusion in diagnosis of HSP, especially in the presence of bullous lesions. Bullous lesions are very rare in children with HSP, whereas they often appear in adults with HSP. We report 2 cases of HSP in whom hemorrhagic bullae manifested predominantly. In our report, the skin biopsies of both patients revealed typical leukocytoclastic vasculitis without IgA and complement depositions on direct immunofluorescence studies. Dramatic improvement of clinical symptoms and signs was observed within a few days after corticosteroids were administered. There was neither recurrence nor nephritis in these 2 patients.- - - - - - - - - - ranking = 0.41666666666667keywords = purpura (Clic here for more details about this article) |
4/8. Hemorrhagic bullous lesions in a child with Henoch-Schonlein purpura.An 8-year-old boy with Henoch-Schonlein purpura who developed hemorrhagic bullae is described. The occurrence of hemorrhagic bullae in children with Henoch-Schonlein purpura is rare. A perusal of the literature revealed but seven occurrences to which we add another one.- - - - - - - - - - ranking = 0.5keywords = purpura (Clic here for more details about this article) |
5/8. Bullous amyloidosis of the oral cavity: a rare clinical presentation and review.Bullous amyloidosis (BA) is a rare cutaneous manifestation primarily of systemic amyloidosis, a disease in which abnormal proteinaceous material is formed and deposited in response to inflammatory conditions and plasma cell dyscrasias. Hemorrhagic bullae indicative of BA are usually associated with purpura and may be the initial clinical signs of systemic amyloidosis or monoclonal gammopathies, such as multiple myeloma and Waldenstrom's macroglobulinemia. Bullous amyloidosis of the oral cavity is highly uncommon and can mimic other vesiculobullous lesions of the oral mucosa. This article highlights an unusual case of oral BA and reviews important aspects of the disease.- - - - - - - - - - ranking = 0.083333333333333keywords = purpura (Clic here for more details about this article) |
6/8. Mega-dose intravenous methylprednisone for the treatment of onyalai: a case report.Onyalai, a peculiar manifestation of idiopathic thrombocytopenic purpura characterized by a haemorrhagic bullae of the oral mucosa and lips, was diagnosed in a 1.5-month-old Turkish boy. He was treated with mega-dose intravenous methylprednisolone (30 mg/kg for 3 days) with prompt platelet response and improvement of oral mucosal findings.- - - - - - - - - - ranking = 0.083333333333333keywords = purpura (Clic here for more details about this article) |
7/8. Idiopathic thrombocytopenic purpura presenting with infraorbital nerve paraesthesia.A case of severe chronic idiopathic thrombocytopenic purpura is reported which presented with infra-orbital paraesthesia and haemorrhagic bullae of the oral mucosa.- - - - - - - - - - ranking = 0.41666666666667keywords = purpura (Clic here for more details about this article) |
8/8. A case of anaphylactoid purpura with multiple blister formation: possible pathophysiological role of gelatinase (MMP-9).A 10-year-old Japanese male with multiple blister formation and palpable purpura in the course of anaphylactoid purpura is described. Histologically, the lesions showed leukocytoclastic vasculitis in the upper dermis with subepidermal clefts. blister fluid showed matrix metalloproteinase (MMP) 2 and MMP-9 gelantinolytic activities using zymography. These enzymatic reactions, especially that involving MMP-9 derived from polymorphonuclear leukocytes, might play an important role in the pathophysiology of this condition.- - - - - - - - - - ranking = 0.5keywords = purpura (Clic here for more details about this article) |