1/24. arsenic-related bowen's disease, palmar keratosis, and skin cancer.Chronic arsenical intoxication can still be found in environmental and industrial settings. Symptoms of chronic arsenic intoxication include general pigmentation or focal "raindrop" pigmentation of the skin and the appearance of hyperkeratosis of the palms of the hands and soles of the feet. In addition to arsenic-related skin diseases including keratosis, bowen's disease, basal-cell-carcinoma, and squamous-cell carcinoma, there is also an increased risk of some internal malignancies. arsenic-related diseases are common in areas of the world where the drinking water has a high arsenic content. In this paper, we describe a 35-year-old male patient who had arsenic-related keratosis, squamous-cell carcinoma in the palmar area of his left hand, and bowen's disease on his left thigh. The patient worked in a borax mine for 15 years, so he was exposed to arsenic in drinking water, airborne arsenic in his workplace, and had direct contact. The patient was treated for 11 months for arsenic-related keratosis until an axillary lymph node metastasis occurred; the lesion was excised and diagnosed to be malignant. bowen's disease was detected when the patient was being treated for cancer. No other malignancy was found. The patient is still receiving regular follow-up care.- - - - - - - - - - ranking = 1keywords = arsenic (Clic here for more details about this article) |
2/24. Bowen's diseases and basal cell carcinomas in a patient.bowen's disease is a well-known precancerous lesion, in which invasive squamous carcinoma may develop. However, it is rare that bowen's disease, basal cell carcinoma, and internal malignancy develop in a single patient. We report a case of a 54-year-old male patient with bowen's disease, basal cell carcinoma of the skin, and squamous cell carcinoma of the lung. Multiple scaly erythematous patches had developed several years earlier and were diagnosed as bowen's disease by skin biopsy. The number of lesions increased and, five months ago, a right lower lobectomy was done for squamous cell carcinoma which was detected on a chest X-ray. Skin biopsies of two different sites revealed bowen's disease and basal cell carcinoma. The arsenic level was increased in his hair specimen. cryotherapy was applied.- - - - - - - - - - ranking = 0.125keywords = arsenic (Clic here for more details about this article) |
3/24. Treatment of arsenical keratosis and bowen's disease with acitretin.BACKGROUND: Long-term exposure to arsenic is associated with the development of arsenical keratosis, bowen's disease, squamous cell carcinoma, and basal cell carcinoma. The efficacy of acitretin therapy was examined in two patients with cutaneous arsenical neoplasms. methods: Lipid profile, hematological and liver function tests were performed regularly during the therapy at monthly intervals. RESULTS: After the third month of treatment, improvement of lesions of arsenical keratosis and bowen's disease were observed in both patients. For the first patient who received 1 mg/kg daily acitretin for 10 months nearly total clearing was obtained at the end of therapy. The second patient discontinued the treatment after a period of 5 months because of symptomatic side-effects. During therapy no new lesions and no laboratory side-effects were observed in either patient. CONCLUSIONS: Although these results need to be confirmed by larger, long-term trials, it appears that acitretin is effective in the treatment of bowen's disease related with arsenic, as well as arsenical keratosis.- - - - - - - - - - ranking = 1.25keywords = arsenic (Clic here for more details about this article) |
4/24. arsenic keratosis and pigmentation accompanied by multiple bowen's disease and genitourinary cancer in a psoriasis patient.We report a case of arsenic keratosis and pigmentation accompained by multiple bowen's disease and genitourinary cancer in a 64-year-old man. He was a psoriasis patient with a history of herbal medication for about thirty years. He showed multiple hyperkeratotic plaques on the bilateral palms, soles, and multiple, brownish, scaly, elevated papules on the back in addition to diffuse hyperpigmentation. biopsy confirmed arsenic keratosis and bowen's disease. Transitional cell carcinoma was also detected on his ureter and bladder during follow-up. The skin lesions were treated with topical 5-fluorouracil, etretinate, and excision with improvement.- - - - - - - - - - ranking = 0.25keywords = arsenic (Clic here for more details about this article) |
5/24. A case of multiple bowen's disease with squamous cell carcinoma of the larynx and adenocarcionoma of the prostate.bowen's disease, or cutaneous squamous cell carcinoma in situ, has been regarded as a cutaneous marker for internal malignancy. However, the relationship of bowen's disease to visceral cancers remains controversial. We present a 76-year-old male with multiple lesions of bowen's disease, who later developed laryngeal cancer and subsequent prostate cancer with distant metastases. Efforts to detect possible common etiologic agents including human papillomavirus and chronic arsenicism revealed no association between bowen's disease and the internal malignancies. Despite the controversy, we suggest that a conservative cancer workup is ethically indicated in patients with multiple bowen's disease.- - - - - - - - - - ranking = 0.125keywords = arsenic (Clic here for more details about this article) |
6/24. Treatment of bowen's disease with topical dinitrochlorobenzene and 5-fluorouracil."bowen's disease" is a clinical and histologic diagnosis describing the lesions (single or multiple) of cutaneous in situ squamous cell carcinoma. The case of a 54-year-old man with 60 such intra-epidermal carcinomas, and a history of arsenic ingestion, is presented. The patient was sensitized to dinitrochlorobenzene (DNCB), and his lesions were treated with a topical DNCB preparation. All lesions disappeared completely (demonstrated by biopsy of several sites) except for a large (12 X 7 cm) tumor on the flank which partially resolved. Total regression of this lesion was achieved by adding topical 5-fluorouracil (5-FU) therapy. This case demonstrates that the inflammatory reaction induced by DNCB (as evidenced by erythema and by a dense inflammatory cell infiltrate in biopsied areas of treated lesions) can lead to regression of extensive in situ epidermoid carcinoma, and that combined therapy with DNCB and 5-FU can be more effective than DNCB alone. Both agents in appropriate concentrations led to selective destruction of neoplastic tissue with no effect on adjacent normal skin. No systemic toxicity was observed.- - - - - - - - - - ranking = 0.125keywords = arsenic (Clic here for more details about this article) |
7/24. Successful treatment of multiple premalignant and malignant lesions in arsenical keratosis with a combination of acitretin and intralesional 5-fluorouracil.A case of arsenical keratosis with multiple lesions of bowen's disease and squamous cell carcinoma is described. The patient was successfully treated with a combination of acitretin and intralesional 5-fluorouracil. All the lesions resolved after three months of therapy with no side effects and no recurrence during four months of follow-up.- - - - - - - - - - ranking = 0.625keywords = arsenic (Clic here for more details about this article) |
8/24. arsenic-induced keratoses and bowen's disease.We report a patient with arsenic-induced keratoses and bowen's disease. Chronic arsenicism may lead to both cutaneous and systemic neoplasms and patients should undergo regular long-term examination. Our patient had widespread cutaneous disease, which responded well to acitretin.- - - - - - - - - - ranking = 0.25keywords = arsenic (Clic here for more details about this article) |
9/24. A case of bowen's disease and small-cell lung carcinoma: long-term consequences of chronic arsenic exposure in Chinese traditional medicine.Chronic arsenic toxicity occurs primarily through inadvertent ingestion of contaminated water and food or occupational exposure, but it can also occur through medicinal ingestion. This case features a 53-year-old lifetime nonsmoker with chronic asthma treated for 10 years in childhood with Chinese traditional medicine containing arsenic. The patient was diagnosed with bowen's disease and developed extensive-stage small-cell carcinoma of the lung 10 years and 47 years, respectively, after the onset of arsenic exposure. Although it has a long history as a medicinal agent, arsenic is a carcinogen associated with many malignancies including those of skin and lung. It is more commonly associated with non-small-cell lung cancer, but the temporal association with bowen's disease in the absence of other chemical or occupational exposure strongly points to a causal role for arsenic in this case of small-cell lung cancer. Individuals with documented arsenic-induced bowen's disease should be considered for more aggressive screening for long-term complications, especially the development of subsequent malignancies.- - - - - - - - - - ranking = 1.25keywords = arsenic (Clic here for more details about this article) |
10/24. Porocarcinoma in a patient with chronic arsenism and multiple bowen's disease: case report.BACKGROUND: Chronic arsenism with bowen's disease is often seen in patients who drink water containing a high level of arsenic. Inorganic arsenic has demonstrated an increased risk of skin cancer. OBJECTIVE: We present a rare case of porocarcinoma in a patient with chronic arsenism and multiple bowen's disease. methods: Report of a case and review of the literature. RESULTS: A case of porocarcinoma arising in a patient with chronic arsenism is presented. The tumor was completely excised by means of wide excision with a 5 mm free margin. The surgical defect was reconstructed with a rhombic flap. CONCLUSION: Chronic arsenism can induce various skin neoplasms, possibly including porocarcinoma.- - - - - - - - - - ranking = 0.25keywords = arsenic (Clic here for more details about this article) |
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