1/6. eccrine porocarcinoma with Bowenoid changes: epithelial membrane antigen is not a useful marker for malignant tumours arising from eccrine gland structures.A case of eccrine porocarcinoma with Bowenoid changes is reported. We compared the results of immunohistochemical staining for epithelial membrane antigen in the present case with results in bowen's disease to determine whether the presence of epithelial membrane antigen (EMA) enabled us to differentiate between bowen's disease and eccrine porocarcinoma with Bowenoid changes. Histologically, the present tumour was characterized by atypical clear cells with Bowenoid changes as well as uniform small cells and intradermal nests with ductal structures. The membrane and cytoplasm of uniform small cells and ductal luminal surfaces were positive for EMA. However, the atypical cells with Bowenoid changes were negative for this. In contrast, tumour cells in bowen's disease were positive for EMA. Although EMA is known to be a useful marker for some benign tumours derived from eccrine ducts, we found it difficult to distinguish eccrine porocarcinoma with Bowenoid changes from bowen's disease using immunohistochemical staining for EMA.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
2/6. Multiple primary cancers in a case of chronic arsenic poisoning--an autopsy report.This is an autopsy report of multiple primary cancers observed in a patient who had clinically been diagnosed as chronic arsenic poisoning. An 88-year-old man, non-smoker, had worked in an arsenic mine for 6 years from the age of 47. He had undergone operations for bowen's disease and gastric cancer at ages 80 and 86, respectively. At autopsy, squamous cell carcinoma of the lung and a polypoid lesion in the piriform recess were found. Furthermore, microscopic examination revealed latent prostatic adenocarcinoma and oncocytoma in the kidney. The polypoid lesion of the piriform recess appeared to originate from the duct of the minor salivary gland in the pharynx, showing an adenoid cystic carcinoma-like pattern with squamous cell carcinoma in part. The cause of death was thought to be respiratory failure due to bronchopneumonia and pulmonary edema as well as hydrothorax, and chronic heart failure following ischemic heart disease. Bowen's disease was followed by four internal malignant tumors, even though the etiological relation between these cancers and arsenic is not clear.- - - - - - - - - - ranking = 0.25keywords = gland (Clic here for more details about this article) |
3/6. bowen's disease with invasive carcinoma showing sweat gland differentiation.A 75-year-old Japanese woman presented an erythematous macular lesion on the flexor aspect of her left wrist. A reddish nodule, 4 mm in diameter, was observed at the medial portion of the macule. The macular lesion was histologically confirmed to be a typical bowen's disease. The nodular lesion was composed of intradermal solid nests of bowenoid neoplastic cells, and in some areas of the dermal component, prominent gland-like structures were observed. Immunohistochemically, most neoplastic cells of the intradermal solid nests were positive with S-100 protein, and the cells lining the gland-like structures along with amorphous material within the lumens were positive with carcinoembryonic antigen. Judging from these findings, this case was diagnosed as bowen's disease with invasive carcinoma, whose dermal component showed sweat gland differentiation not only morphologically but also immunohistochemically.- - - - - - - - - - ranking = 1.75keywords = gland (Clic here for more details about this article) |
4/6. Extramammary Paget's disease. Arising in knee region in association with sweat gland carcinoma.We report a case of extramammary Paget's disease (EMPD) arising in the knee region in association with an underlying sweat gland carcinoma. Inguinal lymph node metastases were present initially. Paget's cells, intradermal tumor cells, and metastatic tumor cells showed similar reactions to a variety of histochemical stains and positive results with immunohistochemical staining using carcinoembryonic antigen (CEA). Control sections in cases of bowen's disease and superficial, spreading malignant melanoma showed a negative staining reaction with CEA, providing further evidence that this technique is useful in distinguishing Paget's disease (PD) from histologically similar conditions. We provide a summary of previous cases of EMPD arising in unusual locations and a brief consideration of possible mechanisms of the origin of PD.- - - - - - - - - - ranking = 1.25keywords = gland (Clic here for more details about this article) |
5/6. Mixed carcinoma in situ: an immunohistochemical study.A case of mixed carcinoma in situ, of the skin, is presented. The lesion, located on the right temple of a 71-year-old man, showed histologic features of bowen's disease and extramammary Paget's disease. This case suggests that bowen's disease and extramammary Paget's disease may arise from pluripotential adnexal epithelium capable of keratinocytic and glandular differentiation. Utilization of the peroxidase-antiperoxidase technique for demonstrating carcino-embryonic antigen was performed in order to identify the component interpreted as extramammary Paget's disease. This procedure is apparently more sensitive than the commonly employed histochemical stains for demonstrating glandular differentiation.- - - - - - - - - - ranking = 0.5keywords = gland (Clic here for more details about this article) |
6/6. Ultrastructural study of extramammary Paget's disease--histologically showing transition from bowenoid pattern to Paget's disease pattern.Histological, immunohistochemical, and ultrastructural studies were performed on two cases of histologically unusual extramammary Paget's disease. Histologically, the central area of the lesions showed a bowenoid pattern, and the peripheral area showed typical extramammary Paget's disease. The transition zone showed an intermediate pattern. All these areas were positive for CEA and EMA, and negative for S-100 protein. Ultrastructurally, in the intermediate pattern, the tumour cells had abundant cytoplasmic glycogen, and the widened intercellular spaces contained numerous glycogen particles, which were probably secreted by the tumour cells. It is well known that eccrine glands, but not apocrine glands, secrete glycogen particles. Therefore, the present findings suggest that some cases of extramammary Paget's disease are a proliferation of germinative cells with eccrine gland differentiation.- - - - - - - - - - ranking = 0.75keywords = gland (Clic here for more details about this article) |