1/8. Arsenic-related bowen's disease, palmar keratosis, and skin cancer.Chronic arsenical intoxication can still be found in environmental and industrial settings. Symptoms of chronic arsenic intoxication include general pigmentation or focal "raindrop" pigmentation of the skin and the appearance of hyperkeratosis of the palms of the hands and soles of the feet. In addition to arsenic-related skin diseases including keratosis, bowen's disease, basal-cell-carcinoma, and squamous-cell carcinoma, there is also an increased risk of some internal malignancies. Arsenic-related diseases are common in areas of the world where the drinking water has a high arsenic content. In this paper, we describe a 35-year-old male patient who had arsenic-related keratosis, squamous-cell carcinoma in the palmar area of his left hand, and bowen's disease on his left thigh. The patient worked in a borax mine for 15 years, so he was exposed to arsenic in drinking water, airborne arsenic in his workplace, and had direct contact. The patient was treated for 11 months for arsenic-related keratosis until an axillary lymph node metastasis occurred; the lesion was excised and diagnosed to be malignant. bowen's disease was detected when the patient was being treated for cancer. No other malignancy was found. The patient is still receiving regular follow-up care.- - - - - - - - - - ranking = 1keywords = palm (Clic here for more details about this article) |
2/8. Arsenic keratosis and pigmentation accompanied by multiple bowen's disease and genitourinary cancer in a psoriasis patient.We report a case of arsenic keratosis and pigmentation accompained by multiple bowen's disease and genitourinary cancer in a 64-year-old man. He was a psoriasis patient with a history of herbal medication for about thirty years. He showed multiple hyperkeratotic plaques on the bilateral palms, soles, and multiple, brownish, scaly, elevated papules on the back in addition to diffuse hyperpigmentation. biopsy confirmed arsenic keratosis and bowen's disease. Transitional cell carcinoma was also detected on his ureter and bladder during follow-up. The skin lesions were treated with topical 5-fluorouracil, etretinate, and excision with improvement.- - - - - - - - - - ranking = 0.16666666666667keywords = palm (Clic here for more details about this article) |
3/8. Circumscribed palmar or plantar hypokeratosis: two cases of a recently described entity of unknown origin.Circumscribed palmar or plantar hypokeratosis is a new entity recently described by Perez et al in 2002. It seems to be underdiagnosed or clinically it is often misdiagnosed as bowen's disease or porokeratosis. Obviously the number of case reports of circumscribed palmar or plantar hypokeratosis has increased since the first publication by Perez et al.The histopathological hallmarks of this condition are a stair-like configuration with an abrupt thinning of the stratum corneum from uninvolved to involved skin with a central hypokeratotic area. There are no atypical keratinocytes or cornoid lamellation.We describe two new patients with circumscribed palmar hypokeratosis. In one case there were additional histopathological features including the loss of granular cell layer in the center of the lesion and an overlying compact thin parakeratotic layer.- - - - - - - - - - ranking = 1.1666666666667keywords = palm (Clic here for more details about this article) |
4/8. bowen's disease of the palm.bowen's disease is a squamous cell carcinoma characterized by isolated, grouped or confluent nodules, either flat, scaling, or crusted, with an arcuate or serpiginous configuration. Malignant dyskeratosis throughout the epidermis, the bowenoid hallmark, is not sufficient by itself to identify a lesion as bowen's disease. It has been suggested, but not proven, that arsenic has a role in the etiology of bowen's disease. A case of bowen's disease affecting the palm, an unusual location, is reported.- - - - - - - - - - ranking = 0.83333333333333keywords = palm (Clic here for more details about this article) |
5/8. bowen's disease and squamous cell carcinoma of the palm.A case of bowen's disease of the palm with associated squamous cell carcinoma is described. A brief general review underlines this unusual localization. bowen's disease may occur at any cutaneous site, simultaneously involving areas protected from and exposed to the light. Involvement of the dorsum of the hand is not rare, but palmar involvement is highly unusual. Only 12 indisputable cases have been published up to the present time.- - - - - - - - - - ranking = 1keywords = palm (Clic here for more details about this article) |
6/8. bowen's disease of the palm. Report of a case in an African.A 45-year-old Nigerian female with bowen's disease (BD) on the left palm is presented. She appears to be the first African case of BD in this unusual location.- - - - - - - - - - ranking = 0.83333333333333keywords = palm (Clic here for more details about this article) |
7/8. Merkel cell carcinoma and multiple bowen's disease: incidental association or possible relationship to inorganic arsenic exposure?An 81-year-old Japanese male was referred to our clinic in 1991 with multiple bowen's disease. The associated hyperpigmentation of the trunk and extremities and palmoplantar keratotic nodules indicated that he had suffered from chronic arsenic poisoning. Interestingly, he was a native of Namikata in Ehime, japan, where many residents have suffered from multiple bowen's disease with internal malignancy. Arsenic exposure was strongly suspected. Two years later, Merkel cell carcinoma developed on the dorsum of his right hand, where bowen's disease lesions were absent. Metastasis of this Merkel cell carcinoma led to his eventual death one year later. To our knowledge, this is the first report of Merkel cell carcinoma associated with multiple bowen's disease. Chronic arsenic poisoning may be responsible for the association of these two rare skin neoplasms.- - - - - - - - - - ranking = 0.16666666666667keywords = palm (Clic here for more details about this article) |
8/8. Intralesional bleomycin.The use of intralesional bleomycin to treat bowen's disease of the palm affecting a motor mechanic is presented. bleomycin in 1% lignocaine was injected at 3-6 week intervals to a cumulative total of 6.35 U. Follow-up at 18 months showed no local recurrence and no long-term adverse events.- - - - - - - - - - ranking = 0.16666666666667keywords = palm (Clic here for more details about this article) |