1/18. HPV 18-induced pigmented bowenoid papulosis of the neck.We describe the case of a 53-year-old man in whom pigmented bowenoid papulosis developed on the skin of the neck. By polymerase chain reaction with general primers for genital human papillomaviruses (HPV) and subsequent restriction enzyme cleavage we could demonstrate HPV 18-related dna in two biopsy specimens of the pigmented papules. To our knowledge, this report represents the first case of HPV 18-induced extragenital bowenoid papulosis of the neck.- - - - - - - - - - ranking = 1keywords = pigmented (Clic here for more details about this article) |
2/18. Pigmented bowen's disease (squamous cell carcinoma in situ): a mimic of malignant melanoma.BACKGROUND: Darkly pigmented individuals may manifest unusual or uncharacteristic presentations of various skin conditions, including heavy pigmentation of cutaneous tumors. OBJECTIVE: To increase the awareness of an unusual presentation of bowen's disease in a darkly pigmented individual. methods: We report the case of a 52 year old black woman that presented with a lesion clinically consistent with malignant melanoma. However, histopathologic examination revealed pigmented bowen's disease. RESULTS: A biopsy is almost always indicated to confirm the diagnosis of lesions in darkly pigmented individuals. CONCLUSION: This case is presented to reinforce the idea that pigmented bowen's disease should be considered in the differential diagnosis of malignant melanoma.- - - - - - - - - - ranking = 0.83333333333333keywords = pigmented (Clic here for more details about this article) |
3/18. bowen's disease clinically simulating an onychomatricoma.Onychomatricoma (OM) is an uncommon benign tumor clinically characterized by a thickened yellowish nail with transverse over curvature. A pigmented variant has recently been described. Histologically, the diagnosis requires 3 prerequisites: (1) a fibroepithelial tumor consisting of 2 portions: the proximal zone (under the proximal nailfold, characterized by deep epithelial invaginations and a fibrillary and fibrocytic stroma), whereas the distal zone (corresponding to the lunula) presents with multiple digitations along its connective tissue axes; (2) a matricial tumor typified by a thick keratogenous zone; and (3) a thick nail plate, perforated by cavities. We describe a case that appears clinically identical to a pigmented OM, but with histologic malignant patterns. Because histologic features were consistent with bowen's disease, we ruled out a malignant OM. We report a new variant of bowen's disease presenting as OM, and this observation underlines the necessity for a histologic assessment of all forms of OM, especially those associated with a pigmented band (a sign sometimes observed in bowen's disease).- - - - - - - - - - ranking = 0.5keywords = pigmented (Clic here for more details about this article) |
4/18. Pigmented bowen's disease mimicking cutaneous melanoma: clinical and dermoscopic aspects.BACKGROUND: Pigmented bowen's disease (BD) (squamous cell carcinoma in situ) has been rarely described among white patients. OBJECTIVE AND methods: We report the case of a 48-year-old white male presenting a lesion of pigmented BD on his left thigh, clinically mimicking a superficial spreading melanoma. RESULTS: Naked-eye physical examination revealed a single 1.8 x 1.5 cm, hyperpigmented plaque with a rough surface, which appeared irregularly shaped and sharply demarcated. The assessment of this uncommon tumor by means of dermoscopy, never reported in literature before, was performed. According to standardized terminology, none among the well-established dermoscopic criteria useful to discriminate between melanocytic and nonmelanocytic origin was detected within the lesion. A reticular pigmentation simulated remnants of atypical pigment network, being of uncertain diagnostic value in the preoperative classification of the lesion. Other recognized patterns were irregular, brown globular structures and wide regression-like areas. None of the features diagnostic for pigmented basal cell carcinoma was found as well. CONCLUSION: The correct classification of nonmelanocytic origin of the lesion was therefore achieved only at histologic examination, after the complete surgical excision. In spite of its rarity, pigmented BD should be included among those lesions, which may simulate cutaneous melanoma. According to criteria validated by literature, dermoscopy failed to improve a preoperative classification of this peculiar skin tumor.- - - - - - - - - - ranking = 0.66666666666667keywords = pigmented (Clic here for more details about this article) |
5/18. Dermoscopic observation of bowen's disease.BACKGROUND: In the literature no specific dermoscopic criteria have been described for the diagnosis of bowen's disease (BD). OBJECTIVE/AIM: To assess the morphological findings of BD seen under dermoscopic observation. methods: Clinical and dermoscopic images of 14 patients affected by BD with various amount of pigmentation were obtained by means of Heine Dermaphot. Dermoscopic images were analysed by experienced observers applying the modified pattern analysis. RESULTS: The most frequently occurring dermoscopic features were found to be: multicomponent pattern (100%); atypical vascular structures (86.6%); absence of pigmented network (64.3%) or presence of pseudo-network (35.7%); irregular diffuse pigmentation or blotches of pigment (64.2%); irregularly distributed dots and globules (64.2%); focal/multifocal hypopigmentation (78.5%), scaly surface (64.2%) and haemorrages (26.6%). CONCLUSIONS: Dermoscopically, BD is mainly characterized by a multicomponent global pattern associated with a prominent vascular pattern (mainly dotted vessels) and a scaly surface. Although no specific dermoscopic criteria can be given for BD, epiluminescence can be a valuable aid in the diagnosis of such a mimicker lesion.- - - - - - - - - - ranking = 0.16666666666667keywords = pigmented (Clic here for more details about this article) |
6/18. bowen's disease involving the urethra.bowen's disease developing on mucous or mucocutaneous regions is clinically called erythroplasia of Queyrat. We report herein a 56-year-old male with bowen's disease extending from the penis shaft to the glans penis, and urethral meatus. physical examination revealed bright red velvety plaques on the prepuce and glans penis and an irregularly pigmented scaly lesion on the dorsum of his penis shaft. Histopathological findings of both lesions were compatible with those of Bowen's disease, supporting the concept that erythroplasia of Queyrat and bowen's disease should be regarded as one clinicopathologic entity. A partial penectomy was finally performed, because tumor cells were pathologically observed in the mucous epithelium of the urethra. Although several therapeutic modalities exist for bowen's disease on the external genitalia, treatment options are limited when bowen's disease extends to the urethral meatus. We discussed the recent therapeutic modalities in genital bowen's disease.- - - - - - - - - - ranking = 0.16666666666667keywords = pigmented (Clic here for more details about this article) |
7/18. bowen's disease: report of a case in a Nigerian man.bowen's disease (cutaneous squamous cell carcinoma in situ), like other cancers of the skin, is rare in black people--to our knowledge, only about 43 cases have been published in the medical literature. We report a 59-year old Nigerian man who presented with a five-year history of a mildly pruritic, slowly enlarging well-circumscribed plaque on the lower part of the anterior region of the chest on the right side. The lesion had an irregular crusted periphery and an atrophic hypopigmented centre. Histological examination confirmed a diagnosis of bowen's disease. No predisposing factor was found to be relevant in this case--although he might have had brief occupational exposure to arsenic, it is unlikely that this was the cause of his disease. The published literature on bowen's disease in blacks is briefly reviewed.- - - - - - - - - - ranking = 0.16666666666667keywords = pigmented (Clic here for more details about this article) |
8/18. Invasive squamous cell carcinoma arising in refractory perianal bowen's disease in a hiv-positive individual.A 54-year-old hiv-positive homosexual man presented with erythematous and pigmented plaques on background erythema in the perianal region, histologically consistent with bowen's disease. Perianal bowen's disease represents high-grade anal intraepithelial neoplasia, which is considered a precursor lesion of invasive anal squamous cell carcinoma. This patient's anal intraepithelial neoplasia was unresponsive to multiple treatment modalities including cryotherapy, serial curettage and cautery, topical 5-fluorouracil and 5-aminolaevulinic acid photodynamic therapy. He progressed to develop a poorly differentiated squamous cell carcinoma of the anus three and a half years after the bowen's disease was diagnosed. The squamous cell carcinoma was treated with combined chemoradiation. A recurrence of high-grade anal intraepithelial neoplasia was noted 6 months after completion of chemoradiation.- - - - - - - - - - ranking = 0.16666666666667keywords = pigmented (Clic here for more details about this article) |
9/18. Pigmented malignant hidroacanthoma simplex mimicking irritated seborrheic keratosis.Pigmented variant of malignant hidroacanthoma simplex (PMHS) is very rare. We are aware of only two reported cases, all arising in pigmented hidroacanthoma simplex (HS). We report the third case of PMHS arising in a pigmented HS. A 71-year-old-woman presented with a well-demarcated pigmented hyperkeratotic tumor on the right knee resembling irritated seborrheic keratosis. Histopathologic examination of the excised tumor revealed intraepidermal proliferation of atypical polygonal poroid cells forming large, sharply demarcated nests with colonization of dendritic melanocytes. In addition, there were focal changes of a benign pigmented HS and syringofibroadenoma. The key diagnostic features of ductal structures and intracytoplasmic lumina were highlighted by carcinoembryonic antigen and epithelial membrane antigen immunostaining. PMHS should be differentiated from irritated seborrheic keratosis, melanoacanthoma, bowen's disease and malignant melanoma both clinically and pathologically.- - - - - - - - - - ranking = 0.66666666666667keywords = pigmented (Clic here for more details about this article) |
10/18. So-called multicentric pigmented bowen's disease. Report of a case and a possible etiologic role of human papilloma virus.Multicentric pigmented bowen's disease (MPBD) is a bowenoid atypia in the genitocrural region with peculiar clinical appearances. A 36-year-old Japanese female patient showed a variety of lesions. Clinically the lesions on the external genitalia consisted of brown-black papillomatous eruptions, black discrete or confluent papules, and whitish macerated papules. Histologically only black papules showed bowenoid atypia, but whitish papules also showed transient bowenoid atypia. Electron microscopically, in all three kinds of the lesions, spherical particles with a diameter of about 50 nm were scattered or gathered together in the nuclei of the keratinocytes beneath the horny layer. These particles were morphologically similar to human papilloma virus. Based upon clinical, histologic and electron microscopic observations, MPBD may be regarded as a new entity, and a term such as multicentric pigmented viral papulosis may be rather preferable than MPBD.- - - - - - - - - - ranking = 1keywords = pigmented (Clic here for more details about this article) |
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