1/24. Human papillomavirus associated bowen's disease of the foot: unique clinical features mimicking a common wart.We describe a case of bowen's disease that developed on the left dorsal foot of a 56-year-old female patient and that mimicked the clinical features of a common wart. PCR-based analysis indicated that the lesion contained HPV-16 dna and HPV-16 positive cells were found in the upper layers of the epidermal lesion using in situ hybridization with an HPV-16 probe.- - - - - - - - - - ranking = 1keywords = wart (Clic here for more details about this article) |
2/24. epidermodysplasia verruciformis associated with neurofibromatosis type 1: coincidental association or model for understanding the underlying mechanism of the disease?We describe a 25-year-old man with epidermodysplasia verruciformis (EV) associated with neurofibromatosis type 1 (NF1). The lesions, persisting for more than 15 years, consisted of widespread planar warts on the backs of the hands and wrists, and reddish-brown macules on the trunk, neck and face. During the last 5 years, our patient developed several epithelial tumours, namely solar keratoses, plaques of bowen's disease and squamous cell carcinomas (SCCs). He also presented with NF1 lesions with neurofibromas, cafe-au-lait macules, axillary freckling and Lisch nodules. He had left tibial bowing. polymerase chain reaction analysis of the skin lesions demonstrated the presence of human papillomavirus (HPV) 15 in a flat wart, HPV 20 in a plaque of bowen's disease, and HPV 15 and HPV 20 in an SCC lesion. Both EV and NF1 show an inherited predisposition to malignancy but the molecular mechanism underlying tumour development is not fully understood. The appearance of both diseases in our patient may be a coincidental association but may also contribute to the identification of loci for susceptibility to NF1 and EV on chromosome 17.- - - - - - - - - - ranking = 0.4keywords = wart (Clic here for more details about this article) |
3/24. Successful treatment of anogenital bowen's disease with the immunomodulator imiquimod, and monitoring of therapy by dna image cytometry.Imiquimod (Aldara, 3M) is an immune response modifier used for the treatment of anogenital warts. We report a 55-year-old non-immunocompromised woman with extensive, human papillomavirus (HPV) 16-positive anogenital bowen's disease. After 5 months of local treatment with imiquimod, the lesions completely regressed clinically and histologically, and HPV 16 dna was no longer detectable. Moreover, dna image cytometry revealed dna aneuploidy (an indicator of prospective malignancy) in pretreatment samples but not in post-treatment samples. Therefore, imiquimod might be a treatment option for bowen's disease, particularly in patients where other treatment modalities such as surgery are contraindicated.- - - - - - - - - - ranking = 0.2keywords = wart (Clic here for more details about this article) |
4/24. Imiquimod for the treatment of bowen's disease and invasive squamous cell carcinoma.Topical imiquimod is an immune response modifier FDA approved for the treatment of anogenital warts. Recent studies have reported its effectiveness in the treatment of some types of basal cell carcinomas. There have also been some case reports and case series reporting success treating of squamous cell carcinoma in situ with imiquimod. We report two patients with squamous cell carcinoma in situ and one with invasive squamous cell carcinoma treated with 5% imiquimod cream. Lesions were located on shin, posterior shoulder, and nasal tip. 5% imiquimod cream was applied at night for six weeks. Side effects included erythema and crusting in one patient. Biopsies taken four weeks after treatment revealed no residual squamous cell carcinoma in situ or squamous cell carcinoma. Topical 5% imiquimod cream is becoming established as a promising treatment for squamous cell carcinoma in situ. It also seems to be an alternative treatment for some cases of squamous cell carcinoma.- - - - - - - - - - ranking = 0.2keywords = wart (Clic here for more details about this article) |
5/24. Bowenoid papulosis at the site of prior herpes progenitalis.A 35-year-old dentist came to the authors' attention for papular and vegetating lesions that had appeared on his penile shaft over the last 2 months. The lesions differed in their features: pink and vegetating on the left side, brown and papular on the right side (Figure 1). The obvious clinical diagnoses of genital warts on the left and Bowenoid papulosis on the right were confirmed by punch biopsies, which showed epithelial hyperplasia with diffuse cell vacuolization (koilocytes)in the left biopsy and moderate nuclear dysplasia in the right one (Figure 2). Human papillomavirus phenotyping was not performed. Interestingly, the patient reported a clear medical history of herpes progenital is (only one episode) that had involved the right side of his glans and prepuce 4 years ago. An immunomodulating treatment with imiquimod was started in the attempt to cure both the genital warts and Bowenoid papulosis lesions (imiquimod was applied three times a week for 8 weeks). At the end of the treatment, the genital warts had disappeared, whereas many Bowenoid papulosis lesions were still present on the right side of the penis (Figure 3). Treated with liquid nitrogen as well, the Bowenoid papulosis lesions disappeared.- - - - - - - - - - ranking = 0.6keywords = wart (Clic here for more details about this article) |
6/24. Human papillomavirus associated with bowen's disease of the finger.We report here a case of bowen's disease that developed in the periungual area of the left ring finger of a 55-year-old Japanese male. Because the histology of the lesion mimicked in part the features of a common wart, a PCR-based analysis of human papillomavirus (HPV) dna and sequencing of viral dna of PCR-amplified fragments were performed. The lesion contained HPV11 and 16 dna, and HPV was suspected to play a role in the development of the lesion.- - - - - - - - - - ranking = 0.2keywords = wart (Clic here for more details about this article) |
7/24. Bowenoid transformation of seborrhoeic verrucae (keratoses).Seborrhoeic verrucae (keratoses) are considered to be benign lesions. Occasional bowenoid transformation of these benign growths has not been widely recognized. Seven cases of seborrhoeic verrucae with bowenoid transformations are presented to alert the clinician and the pathologist to this occurrence.- - - - - - - - - - ranking = 7.4035607260853keywords = verruca (Clic here for more details about this article) |
8/24. dermoscopy in epidermodysplasia verruciformis.BACKGROUND: epidermodysplasia verruciformis (EV) is a rare autosomal recessive genodermatosis characterized by an impairment of cellular immunity. It clinically manifests as widespread, long-lasting, pityriasis versicolor-like macules and flat, wart-like papules, usually occurring in early childhood. There is a risk of development of multiple skin cancers in the third decade, primarily in sun-exposed skin. EV-associated human papillomaviruses have been implicated in a number of cutaneous lesions in non-EV populations, such as seborrheic keratoses or psoriasis. They have also been implicated in the development of nonmelanoma skin cancer, especially in immunosuppressed patients. patients affected with EV are not able to eliminate oncogenic viruses within lesions, leading to a malignant transformation. OBJECTIVE: To describe the dermoscopic characteristics of EV cutaneous tumors by performing histopathologic correlation. methods AND MATERIALS: Cutaneous lesions and tumors from two patients affected by EV were included. Clinical and dermoscopic images were obtained and excision with ulterior histopathology was performed in all suspicious tumors and characteristic lesions. RESULTS: dermoscopy and histology of pityiriasis versicolor-like macules, wart-like papules, seborrheic keratosis-like tumors, psoriasis-like plaques, collision tumors, and Bowen in situ carcinoma are described. CONCLUSIONS: dermoscopy in EV tumors correlated with histopathologic findings and improved the differential diagnosis of tumors in this disease.- - - - - - - - - - ranking = 0.4keywords = wart (Clic here for more details about this article) |
9/24. Oral bowenoid papulosis in an hiv-positive male.Bowenoid papulosis (BP) is a condition triggered by human papillomavirus infection and characterized by the development of 1 or more warty lesions, usually in the anogenital region. Although the oral cavity has been known to host several types of warts, thus far only 4 cases of BP have been reported in this anatomic site. We describe a 42-year-old male with AIDS who presented with numerous papillary lesions of the labial mucosa and vermilion. biopsy yielded a diagnosis of BP. Treatment of the condition consisted of intralesional and subcutaneous injections of interferon-alpha followed by topical application of imiquimod 5% cream. Neither regimen resulted in resolution of the lesions. To our knowledge, this represents the first case of BP arising in the oral mucosa of an hiv-infected individual.- - - - - - - - - - ranking = 0.4keywords = wart (Clic here for more details about this article) |
10/24. Human papillomavirus-35-positive bowenoid papulosis of the anogenital area and concurrent human papillomavirus-35-positive verruca with bowenoid dysplasia of the periungual area.We describe a 42-year-old woman with human papillomavirus (HPV)-35-positive bowenoid papulosis in her anogenital region and HPV-35-positive verruca with bowenoid dysplasia on her right ring finger. The anogenital lesions were diagnosed 11 years before the lesion on her finger developed. We were not able to cure her bowenoid papulosis, since new lesion formation occurred continuously. As pruritus of the anogenital area was always present, scratching may have resulted in autoinoculation. The fact that a "mucosal-type" HPV, which was cloned from a cancer of the uterine cervix, was detected in a dysplastic periungual lesion seems noteworthy. Viral copy numbers appeared to be much higher in the periungual lesion, indicating that in our patient HPV-35 was able to replicate well outside the anogenital area. There are as yet insufficient data on the epidemiology of HPV-35 to conclude how common extragenital infection with HPV-35 is.- - - - - - - - - - ranking = 6.1696339384044keywords = verruca (Clic here for more details about this article) |
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