1/3. Cyclooxygenase-2 inhibition to treat radiation-induced brain necrosis and edema.brain necrosis and edema develop in a proportion of brain tumor patients treated with radiosurgery. Surgical resection and corticosteroids have considerable morbidity. Two metastatic melanoma brain lesions in a 14-year-old girl were treated with radiosurgery and whole-brain radiation treatment. Both lesions became symptomatic from radiologic features of necrosis and edema and were unresponsive to oral corticosteroids. The larger lesion was resected, but the other lesion continued to enlarge. Cyclooxygenase-2 (COX-2) inhibitor was started, and the child improved clinically and radiologically. The usefulness of COX-2 inhibitors in treating radiation necrosis and edema, as suggested by this report, requires further study.- - - - - - - - - - ranking = 1keywords = radiation-induced (Clic here for more details about this article) |
2/3. radiation-induced edema after radiosurgery for pontine arteriovenous malformation. A case report and detection by magnetic resonance imaging.A 29-year-old woman, who had undergone stereotactic radiosurgery for a pontine arteriovenous malformation, experienced sudden onset of facial nerve palsy with trigeminal nerve disturbance 19 months after irradiation. magnetic resonance imaging revealed significant radiation-induced edema surrounding the nidus. angiography demonstrated total obliteration of the arteriovenous malformation 24 months after irradiation. Further magnetic resonance imaging studies, performed 28 months after treatment, showed that, despite the persistence of symptoms, the radiation-induced edema had subsided.- - - - - - - - - - ranking = 0.5keywords = radiation-induced (Clic here for more details about this article) |
3/3. Cerebral edema following iodine-131 therapy for thyroid carcinoma metastatic to the brain.brain metastases are rare in well-differentiated thyroid carcinoma but when present they can lead to the patient's death. iodine-131 therapy for intracerebral thyroid carcinoma metastases causes radiation-induced acute cerebral edema that can lead to CNS complications and even death. We present a case in which a patient with intracerebral 131I uptake developed seizures, slurred speech, and muscle weakness 12 hr following 131I therapy. The patient's CT scan, post-therapy, confirmed an intracranial metastasis with a significant amount of surrounding edema. Radiotherapists, when using external beam radiation to treat intracerebral metastases, commonly place these patients on steroids, glycerol, or mannitol prior to instituting therapy, to prevent complications from radiation-induced cerebral edema. This technique could be applied to 131I therapy of intracranial thyroid carcinoma metastases as well.- - - - - - - - - - ranking = 0.5keywords = radiation-induced (Clic here for more details about this article) |