1/120. Parkinson's syndrome after closed head injury: a single case report.A 36 year old man, who sustained a skull fracture in 1984, was unconscious for 24 hours, and developed signs of Parkinson's syndrome 6 weeks after the injury. When assessed in 1995, neuroimaging disclosed a cerebral infarction due to trauma involving the left caudate and lenticular nucleus. Parkinson's syndrome was predominantly right sided, slowly progressive, and unresponsive to levodopa therapy. reaction time tests showed slowness of movement initiation and execution with both hands, particularly the right. Recording of movement related cortical potentials suggested bilateral deficits in movement preparation. Neuropsychological assessment disclosed no evidence of major deficits on tests assessing executive function or working memory, with the exception of selective impairments on the Stroop and on a test of self ordered random number sequences. There was evidence of abulia. The results are discussed in relation to previous literature on basal ganglia lesions and the effects of damage to different points of the frontostriatal circuits.- - - - - - - - - - ranking = 1keywords = memory (Clic here for more details about this article) |
2/120. Citicoline for traumatic brain injury: report of two cases, including my own.Citicoline is an investigational new drug in this country that was provided on a compassionate use basis in two cases of traumatic brain injury after horseback riding accidents. While this report is primarily anecdotal, the behavioral observations in both cases suggested atypical patterns of improvement and perhaps greater recovery than might otherwise have been predicted. The side effect profile of this drug is negligible and previous experimental research has yielded positive findings for treatment after stroke and head trauma, as well as memory loss in aging. Consequently, Citicoline may potentially be very helpful for patients suffering traumatic brain injuries and should, in our opinion, be made available and studied further in this clinical population.- - - - - - - - - - ranking = 1.0940085248868keywords = memory, memory loss (Clic here for more details about this article) |
3/120. Self awareness: effects of feedback and review on verbal self reports and remembering following brain injury.Brain injury may produce impairments in self awareness. The magnitude of impairment is often determined by comparing patient self reports with self reports of others (report-report) or with patient performance (report-performance). This paper presents data on the pattern of a self-awareness deficit in memory functioning exhibited by a brain injury survivor 5 years post-injury. The effects of practice and feedback on reporting-recall differences was examined using single case methodology. Several prospective and retrospective self reports were obtained, to allow an examination of reporting about past or future recall. Results showed that recall improved and the magnitude of report-recall differences were reduced with practice and feedback.- - - - - - - - - - ranking = 1keywords = memory (Clic here for more details about this article) |
4/120. Retrograde amnesia for world knowledge and preserved memory for autobiographic events. A case report.A patient (PC) with severe and chronic retrograde amnesia for world knowledge (tested with famous events and famous faces), but unimpaired autobiographical memory is described. The 64-year-old man had traumatic brain injury four years prior to the present evaluation. Current brain imaging showed principally damage involving the infero-lateral prefrontal and the lateral temporal regions of the left-hemisphere. PC was of average intelligence, had no depression and only minor language problems, but manifested some additional anterograde memory deficits and performed subaverage in various frontal lobe-sensitive tests. Patient PC represents one of the very few cases with a preserved retrograde episodic and an impaired retrograde knowledge system, showing a dissociation between preserved retrieval of autobiographical events and amnesia for nonpersonal famous events. It is hypothesized that the sparing of autobiographical memories can be linked to the integrity of the right frontal and temporo-polar cortices.- - - - - - - - - - ranking = 6keywords = memory (Clic here for more details about this article) |
5/120. Impaired declarative memory for emotional material following bilateral amygdala damage in humans.Everyday experience suggests that highly emotional events are often the most memorable, an observation supported by psychological and pharmacological studies in humans. Although studies in animals have shown that nondeclarative emotional memory (behaviors associated with emotional situations) may be impaired by lesions of the amygdala, little is known about the neural underpinnings of emotional memory in humans, especially in regard to declarative memory (memory for facts that can be assessed verbally). We investigated the declarative memory of two rare patients with selective bilateral amygdala damage. Both subjects showed impairments in long-term declarative memory for emotionally arousing material. The data support the hypothesis that the human amygdala normally enhances acquisition of declarative knowledge regarding emotionally arousing stimuli.- - - - - - - - - - ranking = 10keywords = memory (Clic here for more details about this article) |
6/120. The relation of phoneme discrimination, lexical access, and short-term memory: A case study and interactive activation account.A brain-damaged patient (AP) is reported who had a strong tendency to identify nonwords as words on auditory lexical decision and to lexicalize nonwords in repetition, yet who showed a normal ability to perceive individual phonemes. It was initially hypothesized that these findings could be accounted for in terms of disrupted lexical phonological representations. This hypothesis was rejected on the basis of an interactive activation model of word recognition which revealed that modifications at the lexical level did not mimic the patient's pattern of results. Instead, it was found that increasing the rate of decay of activation at the phoneme level produced output that was consistent with the phoneme discrimination, lexical decision, and repetition results. This hypothesis of increased phoneme level decay led to the prediction that speech discrimination would decline with increased interstimulus interval and that short-term memory performance would be impaired. Both predictions were confirmed. The results of this study provide support for an interactive activation model of word recognition with feedback from the lexical to the phonemic level and for a close connection between the processes involved in word recognition and short-term memory.- - - - - - - - - - ranking = 6keywords = memory (Clic here for more details about this article) |
7/120. Amnesic confabulatory syndrome after focal basal forebrain damage.A 73-year-old woman developed amnesic confabulatory syndrome after a right focal basal forebrain hemorrhage. The confabulation, despite persistent antegrade amnesia, gradually subsided with improvement of the frontal executive function. The lesion appeared to disrupt connections of the medial and lateral limbic circuits important for memory. Simultaneous dysfunctioning of the two circuits involving the medial temporal and frontal lobes may be necessary for the development of this syndrome.- - - - - - - - - - ranking = 1keywords = memory (Clic here for more details about this article) |
8/120. Factors influencing outcome following mild traumatic brain injury in adults.This study aimed to investigate outcome in adults with mild traumatic brain injury (TBI) at 1 week and 3 months postinjury and to identify factors associated with persisting problems. A total of 84 adults with mild TBI were compared with 53 adults with other minor injuries as controls in terms of postconcussional symptomatology, behavior, and cognitive performance at 1 week and 3 months postinjury. At 1 week postinjury, adults with mild TBI were reporting symptoms, particularly headaches, dizziness, fatigue, visual disturbance, and memory difficulties. They exhibited slowing of information processing on neuropsychological measures, namely the WAIS-R Digit Symbol subtest and the Speed of comprehension Test. By 3 months postinjury, the symptoms reported at 1 week had largely resolved, and no impairments were evident on neuropsychological measures. However, there was a subgroup of 24% of participants who were still suffering many symptoms, who were highly distressed, and whose lives were still significantly disrupted. These individuals did not have longer posttraumatic amnesia (PTA) duration. They were more likely to have a history of previous head injury, neurological or psychiatric problems, to be students, females, and to have been injured in a motor vehicle accident. The majority were showing significant levels of psychopathology. A range of factors, other than those directly reflecting the severity of injury, appear to be associated with outcome following mild TBI.- - - - - - - - - - ranking = 1keywords = memory (Clic here for more details about this article) |
9/120. Automatic activation of positive but not negative attitudes after traumatic brain injury.This study investigated social judgment problems of an individual (AM) with bilateral frontal and temporal lobe damage including damage to the amygdala. We hypothesized that AM could automatically process positive, but not negative evaluative information and could process both types of evaluative information using controlled processing. In Phase 1 of Experiment 1 AM and controls were shown a series of words one at a time and were required to make good/bad judgments as quickly as possible. Results showed that AM was more likely than controls to rate words as good, and was significantly slower to make good/bad judgments of negatively, but not positively, evaluated words. In Phase 2 AM was shown a prime (positive or negative) then target (positive or negative) and instructed to evaluate whether the target word was good or bad. Results showed that AM responded more quickly when prime and target were both positive, but not when prime and target were both negative, whereas controls showed both types of priming. Experiment 2 determined whether AM's impaired processing of negative evaluative information could be abolished under controlled processing. AM was explicitly instructed to generate positive and negative connotations of a series of single words and given essentially unlimited time. Under these conditions, AM and controls did not differ significantly in their ability to generate positive versus negative connotations of words. In Experiment 3 AM and controls both showed normal semantic priming effects. The results are interpreted within the component process model of memory.- - - - - - - - - - ranking = 1keywords = memory (Clic here for more details about this article) |
10/120. To do or not to do? magnetic resonance imaging in mild traumatic brain injury.Clinical quantification of mild traumatic brain injury (MTBI) patients should be based on glasgow coma scale (GCS) score, duration of loss of consciousness (LOC) and post-traumatic amnesia (PTA). In addition, a short practicable neuropsychological test might be useful in detecting minor memory and attentional deficits. MRI appears to be the most sensitive imaging method for assessing MTBI so far, but information regarding a visualized lesion is not usually utilized in the classification of MTBI. magnetic resonance imaging (MRI) should, therefore, play a major role in any MTBI classification scheme. An appropriate MRI protocol has to be chosen using at least T1 weighted, T2 weighted, proton density and gradient-echo (GRE) sequence images, all in at least two planes, in order to detect and classify all lesions precisely. Owing to the fact that acute lesions may be missed, it is advisable to perform MRI in the first 2 weeks following trauma. Further research is necessary to clarify the relationship between chronic symptoms after MTBI and MRI abnormalities. It may, thus, be possible to provide optimal strategies for emergency department management, to define a group of patients with a need for acute and rehabilitative intervention after MTBI, and to predict their outcome.- - - - - - - - - - ranking = 1keywords = memory (Clic here for more details about this article) |
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