1/20. myiasis secondary to Sermatobia hominis (human botfly) presenting as a long-standing breast mass.A case of a 54-year-old woman who presented with a breast mass is reported. Histologically, a chronic granulomatous inflammatory response was observed. The response was associated with an organism diagnosed as a fly larva, Dermatobia hominis (human botfly). The incidence of myiasis, infestation by fly larvae, presenting as a long-standing breast mass and mimicking a neoplasm is extremely rare, especially in the united states.- - - - - - - - - - ranking = 1keywords = neoplasm (Clic here for more details about this article) |
2/20. Primary squamous cell carcinoma of the breast presenting as a breast abscess.Primary squamous cell carcinoma (SCC) of the breast is a very rare neoplasm, with only 75 cases reported in the English literature. Herein, we report four new cases and discuss the diagnostic and therapeutic challenges of this unusual tumor in a retrospective review of all cases of SCC of the breast at our institution from 1990 to 1998. Four patients with breast SCC were identified, with a mean age of 70 years. Two patients with "pure" SCC (no features of ductal carcinoma) were initially treated for breast abscess. Two other patients with features of both SCC and ductal carcinoma had skin erythema associated with an underlying mass, and infectious etiology was considered in each case. Mean tumor size was 4.9 cm. Both patients with pure SCC underwent extensive evaluation for primary tumors at other sites. Two patients developed early systemic metastasis. SCC of the breast is often diagnosed at an advanced stage and may be confused with breast abscess. For this reason, breast biopsy should be considered in cases of breast abscess. Treatment of primary SCC of the breast is similar to that of more common types of breast cancer (i.e., breast conservation is possible and lymph node dissection is recommended). Because metastasis to the breast from other primary tumor sites has been reported (lung, cervix, skin, and esophagus), patients with pure SCC should undergo evaluation to exclude this possibility.- - - - - - - - - - ranking = 1keywords = neoplasm (Clic here for more details about this article) |
3/20. Giant-sized condyloma of the breast with focal acantholytic changes.BACKGROUND: A healthy 26-year-old pregnant woman presented with a 6.0-cm exophytic mass in her left inframammary fold. The lesion was surgically excised. methods: Histopathologic sections of the skin lesion were reviewed in hematoxylin and eosin-stained slides. Additional sections were studied by an in situ hybridization method for human papillomavirus dna (HPV) types 6 and 11. RESULTS: The histopathologic examination demonstrated a benign exophytic, verrucous and papillary epidermal proliferation with features of condyloma acuminatum. Reactivity to HPV dna types 6 and 11 was demonstrated by in situ hybridization method. The epidermis adjacent to, and focally within, the neoplasm showed multiple areas of suprabasilar and intraepidermal acantholysis without dyskeratosis. CONCLUSIONS: Condylomas related to HPV 6 and 11 may be found in extragenital locations including conjunctiva, oral and nasal mucosa. To our knowledge, however, the extragenital condylomas described in the literature have not included the giant-sized variant. We describe an example of a benign, giant-sized condyloma acuminatum of the breast with nearby acantholytic alterations similar to Hailey-Hailey disease.- - - - - - - - - - ranking = 1keywords = neoplasm (Clic here for more details about this article) |
4/20. milk of calcium in the breast: appearance on prone stereotactic imaging.Microcalcifications discovered by mammography require careful analysis, occasionally leading to core biopsy to exclude associated breast cancer. We report unrecognized milk of calcium layering on small field of view prone digital stereotactic images. We illustrate important features on prone digital images attributed to milk of calcium which can exclude breast neoplasm, suggest this diagnosis, and prevent unnecessary biopsy.- - - - - - - - - - ranking = 1keywords = neoplasm (Clic here for more details about this article) |
5/20. Inflammatory myofibroblastic tumour (inflammatory pseudotumour) of the breast. Clinicopathological and genetic analysis of a case with evidence for clonality.Inflammatory myofibroblastic tumours (IMTs) were initially considered to be benign reactive processes, but cases with an unfavourable outcome have been reported. Moreover, clonal genetic alterations have recently been published in some cases, suggesting that IMT may represent a malignant neoplastic entity. This paper reports a case of IMT that developed in the mammary gland, an unusual site. The histological picture was characterized by a proliferation of spindle cells with little cellular atypia and rare mitoses, associated with a polymorphous inflammatory infiltrate. Their immunophenotype, characterized by the expression of vimentin, smooth muscle actin, and cytokeratins, corresponded to that of myofibroblasts. cytogenetic analysis revealed the clonal nature of the lesion. The modal karyotype was 48, X, ins(2;X)(q34;p21.2p22.2), 7, del(9)(p23), 19. Including the present observation, a 9p deletion has now been found in three cases of IMT. These observations show that IMT may be a clonal neoplasm, even in sites different from deep soft tissues.- - - - - - - - - - ranking = 1keywords = neoplasm (Clic here for more details about this article) |
6/20. dirofilariasis of breast: report of two cases diagnosed by fine-needle aspiration biopsy.We report on 2 cases of dirofilariasis of the breast occurring in adult Chinese females residing in hong kong. The diagnosis was made by fine-needle aspiration biopsies. The direct smears contained numerous acute inflammatory cells, including eosinophils. A partially necrotic adult nematode of about 400-450 microm in diameter was identified in the cell-block sections of each case. The worm was characterized by a thick cuticle with longitudinal cuticular ridges and fine transverse surface striations, abundant somatic muscle, an intestine, and a reproductive tube or uterus. The morphologic features of this round worm were most compatible with those of dirofilaria repens. While the clinical and radiologic findings of dirofilariasis of the breast are nonspecific and mimic those of breast neoplasms or inflammatory conditions, a definitive diagnosis is possible with fine-needle aspiration biopsy. A correct diagnosis of dirofilariasis may help to spare patients from unnecessary medical and surgical interventions.- - - - - - - - - - ranking = 1keywords = neoplasm (Clic here for more details about this article) |
7/20. Breast abscess as the initial presentation of squamous cell carcinoma of the breast.Breast abscesses are common and rarely harbour an underlying malignancy. Antibiotics and drainage by aspiration are the mainstays of treatment. We encountered two post-menopausal patients aged 48 and 70 who presented with acute breast abscesses that had an underlying squamous cell carcinoma of the breast. Infective aetiology was considered in each case and pre-operative diagnosis is possible but requires a high level of suspicion to avoid a delay in diagnosis. Aspirate from the abscess should be sent for both culture and cytology and if drainage is done, then biopsy of the abscess cavity is essential. Clinicians should be aware of the association of this rare primary neoplasm of the breast.- - - - - - - - - - ranking = 1keywords = neoplasm (Clic here for more details about this article) |
8/20. Inflammatory intramammary lymph node mimicking the malignant lesion in dynamic MRI: a case report.Enlarged intramammary lymph node (LN) may be caused by inflammation [Arch. Surg. 109 (1974) 759.], reaction to dermatitis [radiology 137 (1980) 15.], tuberculosis [Histopathology 17 (1990) 91.], foreign body such as gold [Hum. Pathol. 19 (1988) 992.], neoplasm including metastasis [Arch. Surg. 109 (1974) 759; AJR, Am J Roentgenol 146 (1986) 133.], and malignant lymphoma [AJR, Am J Roentgenol 161 (1993) 779.]. It is difficult to distinguish benign enlarged LNs from malignant lesion clinically, mammographically, and sonographically. There have been a few reports on the magnetic resonance imaging (MRI) of enlarged intramammary LNs in the English literature. In this article, we present a case in which dynamic MRI indicated inflammatory LNs as highly suspicious of malignancy.- - - - - - - - - - ranking = 1keywords = neoplasm (Clic here for more details about this article) |
9/20. MRI of muscular hamartoma of the breast.Muscular hamartoma is a well-demarcated tumour composed of smooth muscle and adipose tissue. We report the MRI findings of a patient with benign breast neoplasm. To the best of our knowledge, its appearance has not been previously reported.- - - - - - - - - - ranking = 1keywords = neoplasm (Clic here for more details about this article) |
10/20. A developmental anomaly of the mammary glands - gigantomastia. A case report.Developmental anomalies of the breast are frequently observed in women. The most serious pathology is gigantomastia. This type of breast hypertrophy may be caused by hypersensitivity of the breast oestrogen and progesterone receptors, by disturbances of the normal balance of oestrogen and androgen hormones, by hyperthyroidism or by hormonal activity of the neoplasm. In most cases gigantomastia produces pathological changes in the vertebral column which become manifest as discopathia, scoliosis or scoliokyphosis. A case of gigantomastia treated with surgery is presented and the effect of plastic operation is demonstrated. Surgery may be recommended as an excellent therapeutic treatment of gigantomastia.- - - - - - - - - - ranking = 1keywords = neoplasm (Clic here for more details about this article) |
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