1/34. Successful lipid-complexed amphotericin b treatment of Candida arthritis in a lymphoma patient.Fungal arthritis is uncommon but has been increasingly diagnosed over recent years, particularly in patients with immunodeficiency due for instance to hematological malignancies. candida albicans is the most frequent causative agent, and the knee is the joint most often involved. amphotericin b is the drug of choice, but is associated with significant toxicity. Recently developed lipid formulations of amphotericin b have been found as effective and less toxic than the conventional formulation. We report a new case of Candida arthritis that occurred after chemotherapy for nonHodgkin's lymphoma and was successfully treated with lipid-complexed amphotericin b.- - - - - - - - - - ranking = 1keywords = complex (Clic here for more details about this article) |
2/34. amphotericin b lipid complex (ABLC)-associated hypertension: case report and review.amphotericin b (AmB) continues to be the mainstay of therapy for serious fungal infections, despite its relatively toxic side-effect profile. Lipid preparations of the medication have been marketed in the past few years in an attempt to reduce some of these side effects, especially nephrotoxicity. Although 6 cases of severe hypertension associated with the use of AmB deoxycholate have been reported in the literature, no cases of hypertension associated with a lipid-containing preparation of the medication have been reported. We report here the first case of severe hypertension associated with the infusion of AmB lipid complex (ABLC) in a patient with multiple intraperitoneal and urinary fungal pathogens. We also provide a brief review of the previously reported cases of hypertension associated with the deoxycholate formulation of AmB.- - - - - - - - - - ranking = 1keywords = complex (Clic here for more details about this article) |
3/34. Peritoneal penetration of amphotericin b lipid complex and fluconazole in a pediatric patient with fungal peritonitis.Fungal peritonitis is a rare event in patients receiving peritoneal dialysis. This case report describes the blood and dialysate concentrations of fluconazole and amphotericin b following intravenous administration in a 5-month-old infant with candida albicans peritonitis receiving continuous cyclic peritoneal dialysis. fluconazole rapidly and efficiently penetrated the peritoneal fluid achieving concentrations that exceed the minimal inhibitory concentration (MIC) for most Candida species. In contrast, the amount of amphotericin b in the dialysate was below the limit of quantification despite measurable blood concentrations. This suggests that fluconazole represents a better choice for antifungal therapy because of its excellent peritoneal penetration.- - - - - - - - - - ranking = 0.8keywords = complex (Clic here for more details about this article) |
4/34. Successful treatment of candida glabrata endophthalmitis with amphotericin b lipid complex (ABLC).We report a case of Candida (Torulopsis) glabrata endophthalmitis which occurred 2 months following urological surgery. The patient was treated successfully with intravenous amphotericin b lipid complex (ABLC) and flucytosine. diagnosis and management of this condition are discussed.- - - - - - - - - - ranking = 1keywords = complex (Clic here for more details about this article) |
5/34. Candidal abscess in a second primary neoplasm of the neopharynx.A candidal abscess is a known complication of disseminated candidiasis, particularly in immunocompromised patients. We report a second primary growth in the neopharynx brought to light by a candidal abscess in a non-immunocompromised patient.- - - - - - - - - - ranking = 0.30632698824387keywords = neoplasm (Clic here for more details about this article) |
6/34. Eradication of severe neonatal systemic candidiasis with amphotericin b lipid complex.OBJECTIVE: To report the successful use of amphotericin b lipid complex in treating severe systemic candidiasis in a very-low-birth-weight infant. CASE SUMMARY: A preterm female infant, born at 25 weeks' gestational age with a birth weight of 870 g, had received full supportive care in the neonatal intensive care unit (NICU), including mechanical ventilation, total parenteral nutrition, and placement of central venous catheters. At seven weeks of age, she developed severe disseminated candidiasis, which failed to respond to conventional amphotericin b and fluconazole therapy. Her progressive deterioration was reversed only after amphotericin b lipid complex (A-complex) was substituted for conventional amphotericin b. The improvement in her condition was impressive, and she made a full recovery without any adverse effect. DISCUSSION: With increased reliance on invasive technologies for life support, systemic candida infections have become increasingly common among premature infants in the NICU. Such infections are potentially fatal for the high-risk neonate. A literature review shows limited documentation of the use of lipid-based formulations of amphotericin b, especially A-complex, in preterm infants. However, the collective experience with these products appears to show that they are effective and cause fewer adverse effects than conventional amphotericin b. The infant reported here had shown progressive deterioration from disseminated candidiasis until conventional amphotericin b therapy was replaced with A-complex. Her recovery corresponded to the clearance of the candidemia. CONCLUSIONS: With favorable results and increasing experience with lipid-based formulations of amphotericin b, it is reasonable to consider these new formulations as therapy for candidemia in preterm infants who are at a high risk of nephrotoxicity or who have failed conventional therapy.- - - - - - - - - - ranking = 1.8keywords = complex (Clic here for more details about this article) |
7/34. Successful surgical treatment of a mycotic pseudoaneurysm of the ascending aorta in an infant after hypoplastic left heart complex repair.We describe a successfully treated pseudoaneurysm of the ascending aorta in a 2-month-old infant after a previous operation due to hypoplastic left heart complex. After a rapidly progressing respiratory tract obstruction as a first symptom, echocardiography revealed a huge aneurysmal formation originating from the anterior and right lateral wall of the ascending aorta. A patch aortoplasty was employed.- - - - - - - - - - ranking = 1keywords = complex (Clic here for more details about this article) |
8/34. Successful treatment of candida glabrata myocarditis with voriconazole.A 30-y-old man with Crohn's disease developed fungemia with candida albicans. Subsequently, during therapy with fluconazole, candida glabrata was repeatedly isolated from his blood. Myocardial abscesses were detected in the papillary muscles and interventricular septum. The infection was cured with amphotericin b lipid complex and 5-flucytosine, followed by voriconazole for 18 months.- - - - - - - - - - ranking = 0.2keywords = complex (Clic here for more details about this article) |
9/34. Candidal abscess of the parotid gland associated with facial nerve paralysis.facial nerve paralysis associated with parotid gland mass is usually caused by malignant neoplasms and facial nerve dysfunction due to parotid infection is exceedingly rare. A review of the literature revealed approximately 15 cases of facial nerve palsy associated with suppurative parotitis or parotid abscess. We report the first case of candidal abscess of the parotid gland associated with facial nerve paralysis in a 74-year-old insulin-dependent diabetic patient. The differential diagnosis in these unusual cases occurring in diabetic, immunodeficient patients should include candida albicans infection.- - - - - - - - - - ranking = 0.076581747060968keywords = neoplasm (Clic here for more details about this article) |
10/34. glioblastoma, transforming growth factor-beta, and Candida meningitis: a potential link.The development of Candida meningitis in a patient following partial resection of a glioblastoma raised suspicion that transforming growth factor (TGF-beta), an immunosuppressive cytokine known to be produced by this tumor, would be elevated in his cerebrospinal fluid (CSF). By using a highly specific bioassay, the concentration of TGF-beta was found to be 609 pg/mL, which was 10-fold greater than the mean CSF TGF-beta value in control subjects with no neurologic disease. Increased CSF TGF-beta levels were also detected in patients with other central nervous system (CNS) diseases: malignancies and aids dementia complex. These findings suggest that TGF-beta may play an immunopathogenetic role in the CNS.- - - - - - - - - - ranking = 0.2keywords = complex (Clic here for more details about this article) |
| | Next -> |