1/89. Poor outcome of autologous stem cell transplantation for adult T cell leukemia/lymphoma: a case report and review of the literature.A limited number of patients with adult T cell leukemia/lymphoma (ATL) who received autologous stem cell transplantation (ASCT) have been reported. We report here a case of fatal systemic Candida krusei infection in a female patient with ATL undergoing ASCT. All of the eight patients (including seven patients in the literature) with ATL who received ASCT developed relapse of ATL or death due to ASCT complication, irrespective of subtype or remission state of ATL, source or selection of SCT or conditioning regimen. At present, ASCT appears to provide little benefit for ATL in contrast to that for other types of aggressive non-Hodgkin's lymphoma.- - - - - - - - - - ranking = 1keywords = leukemia (Clic here for more details about this article) |
2/89. Surgical management of necrotizing Candida esophagitis.Invasive esophageal candidiasis produced transmural necrosis leading to perforation in 2 patients aged 10 and 27 years. Both patients survived after esophageal resection and complete diversion. One patient with acute leukemia and neutropenia experienced systemic candidiasis, which resolved after esophagectomy. esophagectomy and diversion for yeast-induced necrosis may lead to complete recovery and resolution of disseminated candidiasis when combined with systemic antifungal therapy.- - - - - - - - - - ranking = 0.2keywords = leukemia (Clic here for more details about this article) |
3/89. Successful treatment of candida albicans endocarditis in a child with leukemia--a case report and review of the literature.Candida species is now being increasingly recognised as an important cause of endocarditis especially in immunocompromised patients. A case of candida albicans endocarditis in a child with acute lymphoblastic leukemia (ALL) is reported. The child did not have a central venous catheter at any time. Treatment consisted of intravenous amphotericin b and fluconazole for 3 weeks followed by oral fluconazole for 2 weeks. No surgical resection was necessary. We highlight here the importance of echocardiography in the management of prolonged febrile neutropenia and discuss the dilemma of continuing chemotherapy in such patients.- - - - - - - - - - ranking = 1keywords = leukemia (Clic here for more details about this article) |
4/89. Candida arthritis treated with amphotericin b.This report describes a patient with acute lymphoblastic leukemia who developed arthritis of the knee caused by candida tropicalis. Systemic therapy with amphotericin b apparently suppressed but did not eliminate the infection. Resolution of the arthritis occurred only after three intra-articular injections of amphotericin b. Intra-articular administration of amphotericin b may be a useful adjunct to systemic antifungal therapy in the treatment of these infections.- - - - - - - - - - ranking = 0.2keywords = leukemia (Clic here for more details about this article) |
5/89. Fungal infection of muscle in acute leukemia.A patient with acute lymphoblastic leukemia and granulocytopenia developed fever and diffuse muscle pain and weakness while under therapy. blood cultures grew Candida Krusei and autopsy showed diffuse muscle fungal infestation.- - - - - - - - - - ranking = 1keywords = leukemia (Clic here for more details about this article) |
6/89. Successful treatment using peroral itraconazole in a patient with acute promyelocytic leukemia complicated with splenic candidiasis.A 57-year-old female with acute promyelocytic leukemia was admitted to our hospital. The PML-RAR alpha fusion transcript was reverse transcription polymerase chain reaction. Complete remission was achieved with intensive induction chemotherapy. Then a high fever unresponsive to antibiotics with increased c-reactive protein continued. Abdominal computed tomography revealed multiple low-density lesions in the spleen. Splenic candidiasis was suspected and peroral treatment with itraconazole (200 mg/day) was begun. After the fungal infection was confirmed to be inactive, splenectomy was performed. The splenic tissue showed multiple white or yellow nodules and methenamine silver stain revealed fungal hyphae characteristic to Candida. There was no evidence of relapse of Candida infection. She has been in complete remission for these two years and free of fungal infection. It is indicated from our case that splenic candidiasis in patients with acute myeloid leukemia can be successfully treated with oral administration of itraconazole and subsequent splenectomy, when it is confined in the spleen.- - - - - - - - - - ranking = 1.2keywords = leukemia (Clic here for more details about this article) |
7/89. Chronic systemic (hepatosplenic) candidiasis in a patient with granulocytic sarcoma.Chronic systemic (hepatosplenic) candidiasis (CSC) is a syndrome of invasive candidiasis characterized by fever without localizing signs or symptoms. It occurs predominantly in patients with acute leukemia, after prolonged severe neutropenia. We report a young woman who underwent extensive chemotherapy for granulocytic sarcoma of the ovary; CSC then developed in this patient. She was successfully treated with fluconazole and liposomal amphotericin b. Clinical presentation, diagnostic problems, and the current successful treatment with fluconazole and liposomal amphotericin b are discussed.- - - - - - - - - - ranking = 0.2keywords = leukemia (Clic here for more details about this article) |
8/89. Candida ciferrii, a new fluconazole-resistant yeast causing systemic mycosis in immunocompromised patients.Systemic infections related to fluconazole-resistant yeasts are increasingly observed in immunocompromised patients receiving fluconazole as a prophylactic antifungal treatment. Here, we report a case of invasive candidiasis caused by Candida ciferrii in a patient with acute myeloid leukemia and who suffered a relapse after autologous peripheral blood progenitor cell transplantation. Erythematous skin papulae and spotted pulmonary infiltrations were present. A skin biopsy led to the diagnosis of invasive candidiasis, emphasizing the diagnostic usefulness of this procedure. The yeast was identified as Candida ciferrii and in vitro susceptibility testing revealed its resistance to fluconazole. Until now, Candida ciferrii has not been known to cause invasive fungal infections in humans. Thus, we add another fungus to the list of flucanozole-resistant yeasts and suggest that in vitro susceptibility testing of isolated fungi should be performed for the selection of appropriate antimycotic drugs.- - - - - - - - - - ranking = 0.2keywords = leukemia (Clic here for more details about this article) |
9/89. Hepatosplenic tuberculosis mimicking disseminated candidiasis in patients with acute leukemia.Two cases of hepatosplenic tuberculosis in patients with acute leukemia during or after chemotherapy following prolonged neutropenia are presented. tuberculosis should be considered as one cause of hepatosplenic abscesses during prolonged neutropenia, especially in countries where the disease is endemic.- - - - - - - - - - ranking = 1keywords = leukemia (Clic here for more details about this article) |
10/89. Successful treatment of hepatosplenic candidiasis in an elderly patient with acute myeloid leukemia using liposomal daunorubicin and fluconazole.Fungal infections are an increasing cause of morbidity and mortality in patients with haematological malignancies. The organism most often responsible are Candida spp., particurarly candida albicans. This report describes our experience in a 63-year-old man who developed symptoms of hepatosplenic candidiasis caused by candida tropicalis after treatment for acute myeloid leukaemia (AML). The fungal infection was successfully controlled using fluconazole, and the patient has been disease-free for more than 11 months after antileukemic chemotherapy without any recurrence of Candida infections. Our experience suggests that AML and chemotherapy associated fungal infections can be controlled with an appropriate therapeutic regimen.- - - - - - - - - - ranking = 0.8keywords = leukemia (Clic here for more details about this article) |
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