1/17. Synchronous basal cell carcinoma and meningioma following cranial irradiation for a pilocytic astrocytoma.We report a case of synchronous radiation-induced meningioma and basal cell carcinoma in a 48-year-old man who presented to the plastic surgeons with a fixed scalp lesion sited over a craniotomy scar. Synchronous radiation-induced tumours are a rare occurrence.- - - - - - - - - - ranking = 1keywords = radiation-induced (Clic here for more details about this article) |
2/17. Evidence for an association between hairy cell leukemia and renal cell and colorectal carcinoma.BACKGROUND. Hairy cell leukemia (HCL) has been associated with several disease states. In this study, a possible association is reported between HCL and renal cell carcinoma (RCC) and colorectal carcinoma (CRC). methods. A retrospective study of the case records of 50 patients with HCL in a study of alpha-interferon (alpha-IFN) treatment of HCL. RESULTS. Three of 50 patients with HCL studied had RCC, and 2 of these also had CRC. In addition, two other patients had CRC. The other malignant lesions developed either before or after the diagnosis of HCL. In all patients, the HCL responded to alpha-interferon (alpha-IFN), but in four patients, the second lesion was diagnosed during IFN treatment. CONCLUSIONS. These findings could indicate that IFN does not correct a possible common basic etiologic defect and shows that even early CRC and RCC do not respond to the IFN doses administered. These findings should be considered in future trials of IFN treatment of these diseases. The authors also recommend a reevaluation of the frequency of second malignant lesions in HCL; this may be important particularly with the increased survival in patients with HCL who receive alpha-IFN treatment.- - - - - - - - - - ranking = 0.030164717859022keywords = leukemia (Clic here for more details about this article) |
3/17. Multiple pigmented basal cell carcinomas arising in the normal-appearing skin after radiotherapy for carcinoma of the cervix.BACKGROUND: The most frequent radiation-induced skin cancers are basal cell carcinomas (BCCs), and in many cases, they may occur subsequent to tinea capitis, hypertrophic tonsillitis, acne vulgaris, atopic dermatitis, and hyperthyroidosis. BCCs occurring after radiotherapy for carcinoma of the cervix are extremely rare. OBJECTIVE: To describe a case of multiple pigmented BCCs caused by radiotherapy for carcinoma of the cervix. RESULTS: A 76-year-old female presented with four tumoral lesions within a previously irradiated area. The patient had undergone radiation therapy for cervical cancer 38 years before. All of the lesions were totally excised and histopathologically diagnosed as BCCs. There was no apparent gross chronic radiodermatitis around the lesions, but characteristic histopathologic alterations of radiodermatitis were observed. No new tumors were observed to date. CONCLUSION: The latent period for radiation-induced skin cancer is generally very long; secondary skin cancers can develop very late in life. patients previously treated with radiation therapy require careful follow-up for life.- - - - - - - - - - ranking = 1keywords = radiation-induced (Clic here for more details about this article) |
4/17. Accelerated growth of skin carcinoma following fludarabine therapy for chronic lymphocytic leukemia.We present four patients with chronic lymphocytic leukemia treated with fludarabine, who developed aggressive skin cancer after years of quiescence, a short time after institution of treatment. Their leukemias responded well to therapy with fludarabine with initial treatment as well as relapse. Three patients had recurrence with basal cell carcinomas with multiple, rapidly growing tumors and one had recurrence of both basal and squamous cancers and eventually died of metastatic squamous cell carcinoma. Fludarabine induces prolonged period of lymphopenia, affecting especially the T cell population, which is crucial in the defense against skin cancers. There appears to be a direct association between fludarabine and the flare up of skin cancers in these patients, possibly analogous to the increased incidence of these malignancies in patients on chronic cyclosporine immunosuppression.- - - - - - - - - - ranking = 0.036197661430827keywords = leukemia (Clic here for more details about this article) |
5/17. skin cancer after nonmyeloablative hematopoietic cell transplantation.Squamous cell carcinoma (SCC) is the most common skin cancer in patients receiving immunosuppressive therapy, and is well documented to occur in patients that have undergone either solid organ transplantation or conventional myeloablative bone marrow transplantation. Nonmyeloablative hematopoietic cell transplantation (NMAT) provides transient, intensive immunosuppression, permitting allogeneic engraftment without ablating the marrow. The purpose of this report is to describe six patients that developed SCC (n=3), basal cell carcinoma (n=2), or malignant melanoma (n=2) over a period of 2-26 months following NMAT. All patients had myelodysplasia or acute myelogenous leukemia prior to transplantation. The authors demonstrate for the first time that patients who undergo NMAT are at risk for developing skin cancers and emphasize the need for close surveillance in the post transplantation period.- - - - - - - - - - ranking = 0.0060329435718044keywords = leukemia (Clic here for more details about this article) |
6/17. Basal cell carcinoma in young patients after irradiation for childhood malignancy.Three patients underwent cranial irradiation as part of treatment for childhood malignancy. Two of these patients had acute lymphocytic leukemia and one had an astrocytoma. All had longlasting remissions from their childhood malignancy but 8-15 years later developed a basal cell carcinoma of the scalp within previous radiation portals. The basal cell carcinomas were all treated successfully using Mohs micrographic surgery. Follow-up of patients receiving irradiation for childhood malignancy should include periodic cutaneous examinations of previously irradiated sites.- - - - - - - - - - ranking = 0.0060329435718044keywords = leukemia (Clic here for more details about this article) |
7/17. Facial reconstruction for radiation-induced skin cancer.Radiation-induced skin cancers can be difficult to diagnose and treat. Typically, a patient who has received orthovoltage radiotherapy for disorders such as acne, eczema, tinea capitis, skin tuberculosis, and skin cancer can expect that aggressive skin cancers and chronic radiodermatitis may develop subsequently. Cryptic facial cancers can lead to metastases and death. Prophylactic widefield excision of previously irradiated facial skin that has been subject to multiple recurrent skin cancers is suggested as a method of deterring future cutaneous malignancy and metastases. The use of tissue expanders and full-thickness skin grafts offers an expedient and successful method of subsequent reconstruction.- - - - - - - - - - ranking = 2keywords = radiation-induced (Clic here for more details about this article) |
8/17. Early radiographic changes in radiation bone injury.A chronologic series of periapical radiographs was evaluated for the purpose of detecting damage to bone and tooth-supporting tissues in a patient receiving radiation therapy for a basal cell carcinoma of the mandibular gingiva. Widening of the periodontal space was one of the early radiographic changes observed. It is suggested, from the sequence of radiographic changes, that radiation-induced changed in the circulatory system of the bone might be primarily responsible for the resulting changes.- - - - - - - - - - ranking = 0.5keywords = radiation-induced (Clic here for more details about this article) |
9/17. Aggressive biologic behavior of basal- and squamous-cell cancers in patients with chronic lymphocytic leukemia or chronic lymphocytic lymphoma.Three basal- and four squamous-cell carcinomas in seven patients with chronic lymphocytic leukemia or chronic lymphocytic lymphoma recurred repeatedly after conventional treatment, and grew to large sizes. The squamous-cell carcinomas metastasized in all four of the patients so afflicted. Absolute numbers of circulating T lymphocytes were normal in the seven patients, but they had cutaneous anergy to intradermal tests with common antigens and to dinitrochlorobenzene. The following recommendations for management of cutaneous carcinomas in patients with malignant lymphomatoses are made: 1) closer surveillance than for patients with cutaneous cancers but without malignant lymphomatoses, 2) early treatment of actinic keratoses to prevent possible transformation to malignancy, and 3) microscopically controlled excision of basal- or squamous-cell carcinomas larger than 1 cm in diameter.- - - - - - - - - - ranking = 0.030164717859022keywords = leukemia (Clic here for more details about this article) |
10/17. Surgical treatment of radiation-induced scalp lesions.The treatment of scalp lesions induced by ionising radiation in four patients is described. In each case the technique used was different. Three required several operations and a prolonged hospital stay. The fourth patient, in whom a free flap was used, underwent a single operation. In selected patients with reasonable general health free tissue transfer may provide the best solution to such difficult management problems.- - - - - - - - - - ranking = 2keywords = radiation-induced (Clic here for more details about this article) |
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