1/90. Detection of bilateral multifocal breast cancer using Tc-99m sestamibi imaging. The role of delayed imaging.PURPOSE: Early determination that breast cancer is bilateral and multifocal can change therapy strategy and, subsequently, mortality and morbidity rates. The authors present a case with bilateral, multifocal breast cancer detected only by Tc-99m sestamibi imaging. methods: Early and delayed Tc-99m sestamibi imaging and dynamic MRI were performed in a patient with a right-sided lesion shown on mammography. RESULTS: Although early Tc-99m sestamibi imaging detected bilateral breast cancer foci, both dynamic MRI and mammography missed the lesion in the left breast. Additional lesions seen on delayed Tc-99m sestamibi images of the left breast, which were initially thought to be benign, completely disappeared after concomitant chemotherapy and radiotherapy, suggesting multifocal malignant lesions in the left breast. CONCLUSION: This case suggests that Tc-99m sestamibi may be useful for detecting bilateral cancer, and delayed imaging may give additional information regarding the possible multifocal nature of the disease.- - - - - - - - - - ranking = 1keywords = cancer (Clic here for more details about this article) |
2/90. Contrast-enhanced computed tomography detection of occult breast cancers presenting as axillary masses.Some non-palpable breast cancers presenting as axillary metastases (occult breast cancer, OBC) are not clinically detectable by either mammography (MMG) or ultrasonography (US). We performed contrast-enhanced computed tomography (CE-CT) in order to locate the primary tumors in five cases of OBC and succeeded in locating all of them.- - - - - - - - - - ranking = 0.75keywords = cancer (Clic here for more details about this article) |
3/90. Uterine metastases from breast cancer in a patient under tamoxifen therapy. Case report.The authors report a case of metastases of breast cancer confined to the uterus and cervical subserous leiomyoma in a postmenopausal woman under tamoxifen therapy for two years. After abnormal uterine bleeding, pathologic examination on biopsy of a cervical polyp revealed cervical involvement secondary to lobular breast cancer. The patient underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy. Pathologic examination of the surgical specimen revealed both invasion of breast origin and of the cervix until the isthmus, endometrium and cervical subserous leiomyoma. The adnexa uteri were not affected. The possibility of uterine metastases in patients suffering from breast cancer, either undergoing tamoxifen therapy or not, always has to be considered.- - - - - - - - - - ranking = 0.875keywords = cancer (Clic here for more details about this article) |
4/90. Metastatic breast cancer presenting as tolosa-hunt syndrome.Choroidal involvement is a well-recognized manifestation of metastatic disease, particularly from breast and lung primaries. However, breast cancer can involve other ocular structures. The two patients presented illustrate diffuse orbital involvement of the extraocular muscles, simulating tolosa-hunt syndrome. This association has not been reported previously. Both patients responded well to local radiotherapy.- - - - - - - - - - ranking = 0.625keywords = cancer (Clic here for more details about this article) |
5/90. An advanced case of double primary malignancy involving the breasts and uterine cervix: satisfactory response to non-surgical management.Double primary cancers are fairly rare. We report here a case of metachronous lesions; advanced cancer of the breasts and squamous cell carcinoma of the cervix. What is peculiar in this case is the rather unusual positive response to conservative treatment. Despite widespread metastases even to the liver, the patient is well and active more than six years after breast cancer was first diagnosed. Treating such advanced cases may be rewarding at times.- - - - - - - - - - ranking = 0.375keywords = cancer (Clic here for more details about this article) |
6/90. Lobular carcinoma of the breast in an 85-year-old man.The present study describes a case of the extremely rare histological picture of a lobular carcinoma of the male breast. The 85-year-old patient presented with a tumour in a very advanced stage. The results of genetic studies excluded Klinefelter's syndrome, but a new gene mutation affecting the BRCA1 gene (breast cancer gene 1) was found in the patient.- - - - - - - - - - ranking = 0.125keywords = cancer (Clic here for more details about this article) |
7/90. Response of leptomeningeal metastases from breast cancer to hormonal therapy.Intraventricular chemotherapy with radiotherapy is the standard treatment of leptomeningeal metastasis (LM) from breast cancer; this treatment increases median survival only to about 3 months and is frequently complicated by serious side effects. The authors describe two patients with LM from breast cancer who were treated with hormonal therapy, which provided a neurologic response of at least 12 months and a survival of 14 and 19 months. Hormonal therapy can be effective and nontoxic for patients with LM from breast cancer.- - - - - - - - - - ranking = 0.875keywords = cancer (Clic here for more details about this article) |
8/90. Lymphoepithelioma-like carcinoma of the breast. An unusual pattern of infiltrating lobular carcinoma.A case of breast carcinoma, showing both lymphoepithelioma-like and lobular infiltrating carcinoma, is described, which must be distinguished from the medullary carcinoma with which it shares some features, such as the strong lymphocytic infiltration, but not sharp circumscription, syncytial growth pattern, nuclear pleomorphism, and high mitotic rate. Unlike the lymphoepithelial carcinoma of the nasopharynx and some lympho-epithelioma-like carcinomas of the lung, stomach, salivary glands, and thymus, it does not seem to be connected with Epstein-Barr virus (EBV) infection, as shown by negative results of both in situ hybridization and polymerase chain reaction. This neoplasia may be defined as a peculiar form of lobular carcinoma, therefore, more representative of an unusual microscopic pattern than a distinctive clinicopathologic entity in itself.- - - - - - - - - - ranking = 0.0061932002696625keywords = stomach (Clic here for more details about this article) |
9/90. Non-invasive lobular carcinoma within a fibroadenoma, a preoperatively diagnosed case.breast cancer within a fibroadenoma is rare and usually diagnosed postoperatively from pathological specimens. This paper reports a 54-year-old female with non-invasive carcinoma within a fibroadenoma, diagnosed preoperatively. She underwent a medical examination and mastopathy was suspected. On physical examination a mass 2 cm in diameter was palpated in the left breast. ultrasonography showed a mass with smooth margins and uniform internal echoes, but cytology showed malignancy. mammography showed a round mass with distinct margins and no calcification. As fibroadenoma, diagnosed by ultrasonography and mammography, and breast cancer, diagnosed by cytology, were not consistent results several core biopsies were performed. Needle biopsy showed proliferation of atypical epithelial cells; breast cancer within a fibroadenoma was diagnosed. MRI showed a circular mass with distinct, smooth margins and in a dynamic study, the mass showed irregular staining and the presence of early staining. Left lumpectomy and dissection of the left axillary lymph nodes was performed. Histological examination showed non-invasive lobular carcinoma occurring within a fibroadenoma.- - - - - - - - - - ranking = 0.375keywords = cancer (Clic here for more details about this article) |
10/90. Upper gastrointestinal bleeding as a metastatic manifestation of breast cancer: a case report and review of the literature.CASE PRESENTATION: A 64-year-old woman with known metastatic lobular breast cancer presented with fever, epigastric pain, hematemesis, and melena. A bleeding, ulcerated gastric metastasis was found and was treated with endoscopic therapy, omeprazole, and hormonal therapy. The patient was alive and well 13 months later. The bleeding was probably precipitated by necrosis of the lesion during chemotherapy. DISCUSSION: gastrointestinal tract metastases from primary breast carcinoma are present in 14% to 35% of cases in autopsy series, with gastric involvement in 6% to 18% of cases. Recognized much less commonly during life than in autopsy studies, they can occur anywhere in the gut and can mimic virtually any gastrointestinal disorder. endoscopy and barium studies facilitate diagnosis. Gastric lesions that have been noted include "linitis plastica", nodules, polyps, and ulcers. They are usually due to lobular breast carcinoma and resemble primary gastric carcinoma on microscopy. Reported cases of bleeding gastric metastases have been treated successfully with various local and systemic modalities. The median survival time of reviewed cases was four months from presentation (with a range of zero to 24 months). CONCLUSIONS: Gastrointestinal metastasis is an underdiagnosed complication of breast cancer. Gastrointestinal bleeding from metastatic breast cancer is an uncommon presentation that is readily diagnosed and that can be treated successfully by endoscopic hemostatic therapy.- - - - - - - - - - ranking = 0.875keywords = cancer (Clic here for more details about this article) |
| | Next -> |