1/28. Macular oedema with associated uveitis and cataract following presentation of Type 1 diabetes mellitus in severe ketoacidosis.We present a case of cystoid macular oedema presenting in a newly diagnosed diabetic teenager. She had developed anterior uveitis prior to diabetes and whether this contributed to the subsequent ocular complications remains speculative. The macular changes resolved spontaneously over 6 months without the use of grid laser photocoagulation.- - - - - - - - - - ranking = 1keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
2/28. Acute transient bilateral diabetic posterior subcapsular cataracts(1).A 62-year-old man in whom diabetes was recently detected presented with visually significant, bilateral posterior subcapsular cataracts within days of initiating antihyperglycemic therapy. With efficient control and a stable serum glucose level, the cataracts started regressing. Except for a few scattered opacities, the patient was left with essentially clear lenses. visual acuity of counting fingers at 2 ft in the right eye and 20/63 in the left eye improved to 20/20 in both eyes within 5 weeks.- - - - - - - - - - ranking = 0.035668712125021keywords = diabetes (Clic here for more details about this article) |
3/28. Diabetic neuropathic cachexia and acute bilateral cataract formation following rapid glycaemic control in a newly diagnosed type 1 diabetic patient.In patients with Type 1 diabetes mellitus (DM), the development of complications within the first few years of diagnosis is very unusual and the development of complications within weeks of commencement of insulin therapy is exceptional. Diabetic neuropathic cachexia, unlike the other more common neuropathies associated with diabetes, is a rare form of peripheral neuropathy characterized by profound weight loss, painful dysaesthesias over the limbs and trunk with spontaneous resolution usually occurring within a year. The morphologically distinct diabetic or metabolic cataract in patients with newly diagnosed Type 1 DM is also a rare complication. We describe the first case of a young man with newly diagnosed Type 1 DM who developed these two rare complications within 3 months of diagnosis and insulin therapy commencement. Rapid development of complications in this patient raises two possibilities, i.e. a probable link between the pathophysiology of these two complications following rapid glycaemic control, and a subset of patients with unusual susceptibility to complications. We re-emphasize the need for vigilant monitoring of complications in young diabetic patients, even in the first few years of their disease. In particular, young patients with visual impairment should be evaluated carefully for evidence of treatable eye complications.- - - - - - - - - - ranking = 0.27675153409377keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
4/28. Progressive opacification of hydrophilic acrylic intraocular lenses in diabetic patients.Four patients with diabetes mellitus had cataract extraction with implantation of a hydrophilic acrylic intraocular lens (IOL) (ACRL-C160, Ophthalmed). The IOLs showed progressive and generalized opacification 10 to 20 months after implantation, decreasing visual acuity. All 4 IOLs were removed. By light microscopic examination, the IOL surfaces were wrinkled and encrusted with microspheres. Electron microscopy revealed the material to be crystalline in nature. Energy dispersive x-ray spectrum analysis showed that the deposits were mainly composed of calcium and phosphate.- - - - - - - - - - ranking = 0.24108282196874keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
5/28. Report of a Japanese girl with marfan syndrome associated with insulin-dependent diabetes mellitus.A 3 year old girl was admitted to hospital in an emaciated condition and with polydipsia in October 1974. Following the diagnosis of diabetes mellitus, she received treatment with insulin. On the first admission, a systolic murmur was noted at the apex of the heart. In 1981, the murmur was found to be continuous with a systolic click, and echocardiography demonstrated a mitral valve prolapse. In 1982, electrocardiography revealed left ventricular hypertrophy, and the patient's X-ray showed vertebral kyphoscoliosis. Ophthalmological examination revealed slightly impaired visual acuity and a mild case of cataracts in 1986. The patient grew to be tall and thin with arachnodactylia of the hands, fingers, feet and toes. These symptoms and findings were compatible with marfan syndrome, although the ophthalmological findings are not specific for this disease. This patient is the first case in japan of marfan syndrome associated with insulin-dependent diabetes mellitus, although the relation between marfan syndrome and IDDM remains unclear.- - - - - - - - - - ranking = 1.4933201619306keywords = diabetes mellitus, mellitus, diabetes, insulin-dependent (Clic here for more details about this article) |
6/28. Rapid onset childhood cataracts leading to the diagnosis of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.PURPOSE: To report a case of bilateral cataracts in a child that led to diagnosis of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. DESIGN: Observational case report. methods: A 12-year-old boy was being investigated for weakness, lethargy, short stature, and blurred vision. He developed bilateral, dense cataracts over a 2-week period. He was found to be hypocalcemic and diagnosed with hypoparathyroidism and autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. RESULTS: Because of hypoparathyroidism, adrenocortical failure, and insulin-dependent diabetes, it was 9 months before the patient's metabolic imbalance was brought under sufficient control to allow cataract surgery. CONCLUSIONS: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy should be considered with diagnoses of hypocalcemic cataract.- - - - - - - - - - ranking = 0.045033358148652keywords = diabetes, insulin-dependent (Clic here for more details about this article) |
7/28. Cushing's syndrome caused by unsupervised use of ocular glucocorticoids.OBJECTIVE: To report a case of Cushing's syndrome in an adult patient caused by prolonged and unsupervised use of glucocorticoid ocular drops. methods: We present the clinical and laboratory findings and describe the clinical course of our patient. RESULTS: A 33-year-old man with extensive ophthalmologic complaints and procedures, who had used glucocorticoid ocular drops for an extended period, was referred to the endocrinologist for new onset of type 2 diabetes mellitus. Clinically, the patient appeared cushingoid with a buffalo hump, thin skin, bruises, and purple striae, and his blood pressure was 130/90 mm Hg. Laboratory evaluation revealed a very low serum cortisol level with a concomitantly low-normal level of adrenocorticotropic hormone (corticotropin). In addition, the response to a corticotropin stimulation test was abnormal, an indication of suppression of the adrenal glands. After the patient discontinued the use of the glucocorticoid eyedrops, his cushingoid features gradually faded, and his blood pressure and serum glucose levels normalized. CONCLUSION: Prolonged unsupervised use of glucocorticoid ocular drops may result in Cushing's syndrome and its numerous associated complications. physicians and pharmacists should be aware of this possibility and must educate patients about the potentially serious adverse effects of such use.- - - - - - - - - - ranking = 0.24108282196874keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
8/28. A possible case of werner syndrome presenting with multiple cancers.The treatment of a man with six metachronous primary cancers is described. The primary lesions were in the soft palate, both edges of the tongue, the hard palate, the esophagus, and the right ureter. Pathologically, all of the first five tumors in the head and neck and esophagus were proven to be squamous cell carcinoma with various grades of differentiation, and the last one was transitional cell carcinoma. The cancers were found in the early clinical stage, and were completely controlled one by one except for the ureteral tumor under treatment. His characteristic medical history and physical findings, i.e. bilateral cataracts, short stature, baldness, diabetes mellitus, high-pitched voice, and multiple malignancies, met the clinical criteria for possible werner syndrome, a genetic premature aging disorder, though the possibility of phenocopy of this syndrome has not been ruled out. We have followed him carefully because he might be vulnerable to malignant tumor formation.- - - - - - - - - - ranking = 0.24108282196874keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
9/28. "Star" suture opacities of the crystalline lens: an illustrative report in AIDS patients.BACKGROUND: acquired immunodeficiency syndrome (AIDS) is disease of epidemic proportion associated with significant visual morbidity. Visual complications of AIDS have been described as a result of cytomegaloviral retinitis as well as fungal and protozoan opportunistic eye disease. Although cataracts have been established as a direct consequence of human immunodeficiency virus (hiv) or AIDS, studies suggest that hiv disease may indeed be a risk factor for the development of cortical cataract. This report further characterizes potential lens abnormalities associated with hiv and AIDS by clearly demonstrating opacities associated with lens sutures in two AIDS patients with long-term use of nucleoside analogue reverse transcriptase inhibitors (NRTIs). MATERIAL/ methods: Case series demonstrating digitized slit lamp biomicroscopic anterior segment photos using indirect lens illumination. RESULTS: Prominent "star" lens sutures of assumed abnormality typified by unusual branching and irregular caliber are photo-documented. CONCLUSIONS: Normally inconspicuous star suture branches are clearly demonstrated in two patients with AIDS and diabetes mellitus. Uncharacteristic star lens sutures have not Been previously reported in AIDS patients however the occurrence of lens opacities due to hiv disease and AIDS is not without precedent. Despite the prominence and atypical nature of the illustrated lens sutures, assessment of morphologic abnormality is limited by lack of appropriate normative data describing star sutures clinically as a function of age and lens development.- - - - - - - - - - ranking = 0.24108282196874keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
10/28. Rapid onset of severe retinopathy, cataracts and neuropathy in young patients with diabetes mellitus.It is rare for young diabetic patients to develop severe complications in the first years of their disease. We describe three patients, aged 14-23 years who developed cataracts and severe retinopathy within one to five years of diagnosis of diabetes. During the same period, one patient developed peripheral neuropathy and a second severe autonomic neuropathy. Rapid development of chronic complications in these patients raises the possibility that there may be a subset of patients with unusual susceptibility to complications. We re-emphasize the need for vigilant monitoring for complications in young diabetic patients, even in the first few years of their disease. In particular, young patients with visual complaints should be evaluated carefully for evidence of treatable eye disease.- - - - - - - - - - ranking = 1keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
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