1/47. Cervical adenoid cystic carcinoma coexisting with multiple human papillomavirus-associated genital lesions. A common etiology?Adenoid cystic carcinoma of the uterine cervix is a rare tumor with unknown etiology. We report a case of adenoid cystic carcinoma occurring in a young woman, associated with multiple human papillomavirus (HPV)-related lesions including condyloma acuminata, vulvar intraepithelial neoplasm, cervical intraepithelial neoplasm and invasive basaloid squamous cell carcinoma. While adenoid cystic carcinoma has previously been found to coexist with squamous cell carcinoma or cervical intraepithelial neoplasia, its association with such a variety of HPV-related lesions in our case has not been previously reported, and raises the speculation that HPV may also be the causative factor for adenoid cystic carcinoma. However, in situ dna hybridization and polymerase chain reaction in our current study failed to demonstrate the existence of HPV dna in adenoid cystic carcinoma.- - - - - - - - - - ranking = 1keywords = cervical intraepithelial, cervical intraepithelial neoplasia, intraepithelial neoplasia, intraepithelial, neoplasia (Clic here for more details about this article) |
2/47. Large cell neuroendocrine carcinoma of the uterine cervix: a report of a case with coexisting cervical intraepithelial neoplasia and human papillomavirus 16.Large cell neuroendocrine carcinomas (LCNECs), one of the four newly categorised endocrine tumors of the uterine cervix, are unusual and aggressive tumors. The present report describes a case of LCNEC diagnosed at an early stage and associated with cervical intraepithelial neoplasia (CIN). The LCNEC showed organoid and trabecular growth patterns and was positive for chromogranin and synaptophysin. The CIN lesion was of a high grade and was negative for these neuroendocrine markers. polymerase chain reaction (PCR) using genomic dna extracted from archival tissue demonstrated human papillomavirus (HPV) type 16 dna in both the LCNEC and CIN lesions. These histological, immunohistochemical and PCR findings suggested that the LCNEC lesion was distinct from the CIN lesion and that both resulted from the carcinogenic field effect of HPV 16.- - - - - - - - - - ranking = 2.9557489754432keywords = cervical intraepithelial, cervical intraepithelial neoplasia, intraepithelial neoplasia, intraepithelial, neoplasia (Clic here for more details about this article) |
3/47. Anogenital intraepithelial lesions in hiv positive patients. Report of 3 cases with 3-year follow-up.Three cases of hiv-positive immunocompromised women, complicated by anogenital intraepithelial lesions are presented in the present paper. Two patients, aged 42 and 33, had a combination of cervical intraepithelial neoplasia grade 3 (CIN 3) and anal intraepithelial neoplasia grade 2 (AIN 2). The other one, aged 26, presented an association of CIN 2 and AIN 1. All lesions were HPV-associated and proved by colposcopically-guided biopsies.- - - - - - - - - - ranking = 0.6701723138758keywords = cervical intraepithelial, cervical intraepithelial neoplasia, intraepithelial neoplasia, intraepithelial, neoplasia (Clic here for more details about this article) |
4/47. Human papillomavirus infection in atrophic smears. A case report.BACKGROUND: Human papillomavirus (HPV) infection in atrophic smears can be misleading and may produce the diagnosis of cervical intraepithelial neoplasia. CASE: A routine cervical smear in a 62-year-old female revealed an atrophic smear with nuclear changes suggestive of a high grade squamous intraepithelial lesion (HSIL). An estrogen cream for topical vaginal use was prescribed. A new smear was collected seven days later and revealed koilocytosis but no evidence of HSIL. CONCLUSION: Koilocytosis is a cellular finding of mature epithelial cells. The use of estrogen produces maturation of HPV-infected basal cells, allowing a correct diagnosis of this disease in patients with atrophic smears.- - - - - - - - - - ranking = 0.60159713866664keywords = cervical intraepithelial, cervical intraepithelial neoplasia, intraepithelial neoplasia, intraepithelial, neoplasia (Clic here for more details about this article) |
5/47. Cervical intra-epithelial neoplasia (CIN) III of the uterine cervix in a young female associated with AIDS.A case of cervical intraepithelial neoplasia (CIN) III implying severe dysplasia or carcinoma in situ of the uterine cervix in a 24 year old Japanese female patient with acquired immunodeficiency syndrome (AIDS) is reported. autopsy revealed marked systemic atrophy of lymph nodes, pneumocystis carinii pneumonia, pulmonary aspergillosis, acute pancreatitis and CIN III of the portio vaginalis uteri. The human papillomavirus (HPV) genome was detected in sections of the CIN III by polymerase chain reaction. This is the first autopsy report of cervical neoplasia in a patient with AIDS in japan, and the pathogenesis of CIN III in this case was associated with HPV infection. gynecological examination should be mandatory for female patients with human immunodeficiency virus infection.- - - - - - - - - - ranking = 0.59211670731353keywords = cervical intraepithelial, cervical intraepithelial neoplasia, intraepithelial neoplasia, intraepithelial, neoplasia (Clic here for more details about this article) |
6/47. Cervicovaginal psammoma bodies in endosalpingiosis. A case report.BACKGROUND: The presence of psammoma bodies on cervicovaginal smears is a rare finding. These structures have usually been associated with malignant tumors, particularly ovarian carcinoma. However, a review of the literature reveals that up to 50% of these patients will have psammoma bodies in association with benign conditions; thus, this finding does not always correlate with the presence of a malignant tumor. CASE: An asymptomatic, nulliparous woman had psammoma bodies on a cervicovaginal smear. Evaluation, including cervical conization, endometrial sampling, laparoscopy with pelvic washings and ovarian biopsy, revealed cervical intraepithelial neoplasia 1, endosalpingiosis and numerous psammoma bodies in all specimens except from the cervix. Follow-up examinations at three and six months were negative. CONCLUSION: The finding of psammoma bodies in a Pap smear is not always associated with the presence of a pelvic malignancy.- - - - - - - - - - ranking = 0.026785800897185keywords = intraepithelial neoplasia, intraepithelial, neoplasia (Clic here for more details about this article) |
7/47. Utility of trichrome and reticulin stains in the diagnosis of superficial endometriosis of the uterine cervix.Superficial endometriosis of the uterine cervix is a not uncommon lesion and the cells on the cervicovaginal smear shed from it can be easily mistaken for cervical glandular intraepithelial neoplasia (CGIN). The correct diagnosis can not always be easily made on H&E stained tissue sections unless it is suspected. The endometriotic stroma is often misinterpreted as stromal hypercellularity or postinflammatory fibrosis following erosion or ulceration of the cervical mucosa. Moreover, the endometriotic glands may resemble tubo-endometrioid metaplasia of the endocervical glands. This article describes the utility of trichrome and reticulin stains in the diagnosis of superficial cervical endometriosis. The absence of abundant thick collagen bundles and the investment of individual stromal cells by a fine reticulin network within the endometriotic foci are characteristic histologic features. These findings are not observed in the surrounding normal cervical stroma nor in the usual conditions in the differential diagnosis.- - - - - - - - - - ranking = 0.026785800897185keywords = intraepithelial neoplasia, intraepithelial, neoplasia (Clic here for more details about this article) |
8/47. Successful treatment of recurrent vulvar intraepithelial neoplasia resistant to interferon and isotretinoin with cidofovir.Vulvar intraepithelial neoplasias are difficult to eradicate completely without extensive surgical intervention. Cidofovir, a deoxycytidine monophosphate analog, may have a therapeutic role in this disease. A 43-year-old woman with a 20-year history of genital warts presented with extensive vulvar intraepithelial neoplasia III, and refused surgical resection. Topical cidofovir 1% in Beeler base completely eradicated the lesion. Successive treatment applications, however, were necessary. Cidofovir is a promising topical antiviral compound for HPV induced vulvar intraepithelial neoplasia.- - - - - - - - - - ranking = 0.1875006062803keywords = intraepithelial neoplasia, intraepithelial, neoplasia (Clic here for more details about this article) |
9/47. Abnormal cervicovaginal smears due to endometriosis: a continuing problem.endometriosis may be challenging when identified on cervicovaginal smears (CVS), leading to an incorrect interpretation of high-grade squamous intraepithelial lesion (HSIL), or atypical glandular cells of undetermined significance (AGUS) including adenocarcinoma in situ (AIS). awareness of cervical endometriosis, particularly in predisposed patients, is crucial for a correct diagnosis. While cervical endometriosis has been reported to be a diagnostic pitfall of glandular abnormalities, its characteristic features are still not well-established. This may partially be attributed to the varied cytomorphologic features endometriosis shows, depending on menstrual cycle hormonal changes. We describe our experience with three examples where CVS were interpreted as either AGUS or HSIL, which led to a hysterectomy in 2 of 3 patients. Cervical endometriosis needs to be considered with other well-known benign conditions that mimic glandular abnormalities, including cervicitis, tubal metaplasia, lower uterine segment sampling, and microglandular hyperplasia. Published series and our own experience lead us to suggest that these smears will continue to present diagnostic difficulties.- - - - - - - - - - ranking = 0.010447343577994keywords = intraepithelial (Clic here for more details about this article) |
10/47. Improved outcome of cervical neoplasia in hiv-infected women in the era of highly active antiretroviral therapy.Cervical neoplasia has been associated with human immunodeficiency virus (hiv) infection. Both preinvasive disease and invasive cervical cancer have been reported to have a much poorer outcome in hiv-infected women than in the general population. The use of highly active antiretroviral therapy (HAART) has resulted in significant improvements in the treatment of hiv infection, including a decrease in the incidence and severity of several acquired immune deficiency syndrome (AIDS)-related malignancies. Two cases of cervical dysplasia in hiv-infected women are presented, one from the pre-HAART era, who subsequently developed invasive cervical cancer and died, and one in whom HAART was used with good outcome. Data from several reports of the use of HAART in hiv-infected women indicates that the prognosis for cervical neoplasia is improved. Possible reasons for this improvement include better immune function seen in HAART-treated women, as well as increased surveillance for cervical neoplasia in hiv-infected women in recent years. However, the future impact of improved hiv care, including HAART, on cervical neoplasia is unclear.- - - - - - - - - - ranking = 0.0015470595598085keywords = neoplasia (Clic here for more details about this article) |
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