1/2. Giant chalazia in the hyperimmunoglobulinemia E (hyper-IgE) syndrome.PURPOSE: To report the occurrence of recurrent multiple giant chalazia in the hyperimmunoglobulin E syndrome (hyper-IgE syndrome or job syndrome). methods: Two patients with hyperimmunoglobulinemia E (>500 IU/ml) had ophthalmologic examination and surgical treatment for chalazia of the eyelids. RESULTS: The hyper-IgE syndrome is a rare immunodeficiency and multisystem disorder characterized by recurrent skin and pulmonary abscesses, connective tissue abnormalities, and elevated levels of serum IgE. In two patients with the hyper-IgE syndrome, multiple giant chalazia were seen in upper and lower eyelids. Despite surgical incision new giant chalazia arose. CONCLUSIONS: Recurrent multiple giant chalazia may occur as an ophthalmic feature of the hyper-IgE syndrome.- - - - - - - - - - ranking = 1keywords = hyperimmunoglobulinemia (Clic here for more details about this article) |
2/2. Recurrent staphylococcus aureus chalazia in hyperimmunoglobulinemia E (Job's) syndrome.PURPOSE: To report a case of recurrent staphylococcus aureus chalazia in a patient with hyperimmunoglobulinemia E syndrome (Job's Syndrome). DESIGN: Case report. methods: Three separate surgical incisions and curettages of multiple, recurrent chalazia of the right upper eyelid were performed over a course of 3 months. Cultures and pathologic specimens were obtained. Postoperative treatment consisted of oral erythromycin and amoxicillin/clavulonate, topical tobramycin/dexamethasone ointment, and warm compresses. RESULTS: pathology of the tarsus confirmed the diagnosis of multiple chalazia. Cultures of the chalazia contents were positive for staphylococcus aureus. No further recurrence was observed following the third surgical procedure over a 3-month follow-up period. CONCLUSION: Characteristic staphylococcus aureus skin infections in immunodeficient patients with hyperimmunoglobulinemia E syndrome can involve the eyelids and may be recurrent despite appropriate medical and surgical therapy.- - - - - - - - - - ranking = 1.2keywords = hyperimmunoglobulinemia (Clic here for more details about this article) |