1/7. Annular elastolytic giant cell granuloma: sparing of a burn scar and successful treatment with chloroquine.Annular elastolytic giant cell granuloma is a rare granulomatous skin disease characterized by phagocytosis of elastic fibres by multinucleated giant cells. Lesions are either solitary or grouped in a few annular patches with elevated borders and central atrophy. Sun-exposed areas are more commonly involved than covered skin. The pathogenesis of the disease is still controversial. We report a 72-year-old fair-skinned woman with unusual clinical findings. An irregularly shaped erythematous plaque covered the entire face, and hundreds of lichenoid papules were present on both sun-exposed and covered areas which gradually evolved into annular lesions of about 0.5-1 cm in diameter. Sparing of an old burn scar and a nearly complete lack of elastic fibres in the scar site were noted, illustrating the presumed importance of dermal elastic tissue in the pathogenesis. The course of the disease is chronic. Several treatments have been tried, with variable success. In our patient, improvement was achieved with chloroquine over a period of 16 weeks.- - - - - - - - - - ranking = 1keywords = skin disease (Clic here for more details about this article) |
2/7. Trauma-localized fixed drug eruption: involvement of burn scars, insect bites and venipuncture sites.Little is known about why fixed drug eruption (FDE) lesions initially appear in a particular area of predilection. We describe 2 cases in whom the FDE lesions initially appeared exactly at the same sites of a previous trauma, such as burn scars and insect bites, and at a venipuncture site. The interval between the original trauma and the initial onset of FDE ranged from 2 days to 22 years. These 'trauma-localized' FDE lesions are helpful for our understanding of the mechanisms of FDE and other skin diseases, which often appear in their particular areas of predilection, a finding known as 'recall phenomenon'.- - - - - - - - - - ranking = 1keywords = skin disease (Clic here for more details about this article) |
3/7. pemphigus foliaceus masquerading as postoperative wound infection: report of a case and review of the Koebner and related phenomenon following surgical procedures.BACKGROUND: The Koebner phenomenon, also known as the isomorphic response, is the development of preexisting skin disease following trauma to uninvolved skin. Various cutaneous disorders have been described to arise at surgical wounds and scars. Moreover, dermatologic procedures, such as cold-steel and laser surgery, can evoke koebnerization. OBJECTIVE: To describe a case of pemphigus foliaceus arising in postoperative wounds and to present a review of dermatologic disorders triggered by surgical procedures. methods: We report a case of pemphigus foliaceus initially presenting at sites of Mohs' micrographic surgery, shave biopsy, and cryotherapy and, subsequently, at a nonsurgical site. We reviewed the English literature in medline from November 1955 to April 2004 for reports of Koebner and related phenomenon following surgical procedures. RESULTS: To our knowledge, this is the first reported case of pemphigus foliaceus erupting at surgical and cryotherapy wounds. The clinical appearance can mimic wound infection. In addition to inducing preexisting disease, cutaneous procedures can also trigger the onset of new disease, which can either be limited only to the surgical site or subsequently become generalized. CONCLUSION: Postoperative Koebner or related responses should be included in the differential diagnosis of poorly healing surgical wounds. Skin biopsies for histopathology and immunologic studies may be necessary for definitive diagnosis and optimal management.- - - - - - - - - - ranking = 1keywords = skin disease (Clic here for more details about this article) |
4/7. Koebner's phenomenon and necrobiosis lipoidica diabeticorum.In 1877, Dr Heinrich Koebner inflicted an experimental trauma on the uninvolved skin of a psoriatic patient. This resulted in the appearance of a typical psoriatic lesion at the site of trauma. This reaction, known as Koebner's phenomenon (KP), has subsequently been associated with several skin diseases. However, it has not been associated previously with necrobiosis lipoidica diabeticorum (NBL), a rare skin manifestation of diabetes mellitus. This report presents the unusual finding of NBL associated with KP in a patient with diabetes mellitus.- - - - - - - - - - ranking = 1keywords = skin disease (Clic here for more details about this article) |
5/7. Familial elastosis perforans serpiginosa.BACKGROUND--Elastosis perforans serpiginosa (EPS) is an uncommon skin disease characterized by transepidermal elimination of abnormal elastic fibers. The disease is frequently associated with congenital connective tissue disorders or Down's syndrome. The pathogenesis of EPS is still unclear. There are a few reports in the literature about a familial occurrence of EPS in which different modes of inheritance are suggested. To support the hypothesis of a congenital origin of the disease, we have studied another family with EPS. OBSERVATIONS--In this study, we describe a family in which two sisters and a brother were affected by EPS. The father and three paternal uncles were most probably affected by the same disease. There were no signs of other congenital connective tissue disease in the family members. CONCLUSION--An autosomal dominant mode of inheritance with variable expression of EPS is suggested.- - - - - - - - - - ranking = 1keywords = skin disease (Clic here for more details about this article) |
6/7. Cicatrizing conjunctivitis as a predominant manifestation of linear iga bullous dermatosis.linear iga bullous dermatosis is an uncommon mucocutaneous autoimmune disorder that is distinct from dermatitis herpetiformis and bullous pemphigoid. Two patients who had significant conjunctival involvement but minimal skin disease are described. Irreversible conjunctival scarring indistinguishable from ocular pemphigoid developed in both patients.- - - - - - - - - - ranking = 1keywords = skin disease (Clic here for more details about this article) |
7/7. Follicular mucinosis associated with scarring alopecia, oligoclonal T-cell receptor V beta expansion, and staphylococcus aureus: when does follicular mucinosis become mycosis fungoides?A diagnosis of alopecia mucinosa, occurring as a single scalp lesion, was made in a 40-year-old white woman who had a history of trauma. Follicular mucinosis, staphylococcus aureus, and oligoclonal expansion of the T-cell receptor V beta chain genes 6 and 7 were present in the skin. Epidermotropic T-cell skin diseases with oligoclonal T-cell proliferations may be the result of HLA- and cytokine-determined reaction patterns to persistent antigens.- - - - - - - - - - ranking = 1keywords = skin disease (Clic here for more details about this article) |