1/11. Biliary papillary hyperplasia with clonorchiasis resembling cholangiocarcinoma.infection by the liver fluke clonorchis sinensis is very common in the far east. It causes low grade inflammatory changes and proliferation in the biliary tree. Initially there is desquamation of the biliary epithelium, followed by hyperplasia and adenomatous proliferation. Cholangiocarcinomas are potential long term complications. We present a case of biliary papillary hyperplasia with clonorchiasis resembling cholangiocarcinoma in a 69-yr-old Korean man. Early recognition of biliary hyperplasia and treatment of clonorchis sinensis is important to prevent development of cholangiocarcinoma, especially in the far east.- - - - - - - - - - ranking = 1keywords = cholangiocarcinoma, carcinoma (Clic here for more details about this article) |
2/11. Composite neuroendocrine and adenocarcinoma of the common bile duct associated with clonorchis sinensis: a case report.The biliary tract has neuroendocrine cells of endoderm origin similar to the gastrointestinal tract, however neuroendocrine tumors of the biliary tract are rare. We report a composite glandular-endocrine cell carcinoma of the common bile duct in a 64-year-old Korean man which was associated with clonorchis sinensis. The patient complained of right upper quadrant abdominal pain. Several parasites of clonorchis sinensis were removed during the percutaneous transbiliary drainage. Endoscopic retrograde cholangiopancreatography revealed a polypoid mass (3 x 3 cm) with central ulceration in the common bile duct. pancreaticoduodenectomy was performed. Microscopic examination of the tumor revealed a composite small cell neuroendocrine carcinoma and adenocarcinoma. The small cell carcinoma component showed positive reaction to chromogranin a and neuron-specific enolase and it was located mainly in the deeper portion of the mass. The well-differentiated adenocarcinoma component showed a positive reaction to carcinoembryonic antigen and it was situated in the superficial portion of the mass. Exclusively, the small cell component metastasized to the lymph node. It is suggested that this tumor could arise from a multipotential stem cell and showed neuroendocrine and glandular differentiation and that clonorchis sinensis could be a predisposing factor, as in cholangiocarcinoma.- - - - - - - - - - ranking = 0.1668089932464keywords = cholangiocarcinoma, carcinoma (Clic here for more details about this article) |
3/11. Clonorchis-associated cholangiocarcinoma: a report of two cases with unusual manifestations.Two cases of Clonorchis-associated cholangiocarcinoma are described along with their cholangiographic features to illustrate the spectrum of pathology ascribed to the injurious effects of the flukes on the bile duct epithelium. This includes adenomatous hyperplasia, extensive fibrosis, and carcinoma. The first case was also complicated by hepatic abscesses, left hepatic lobar atrophy, gastrobiliary and biliarocutaneous fistulae. The second case features an unusually dilated pancreatic duct containing pancreaticoliths that was found later to consist of hyperplastic bile duct epithelium, presumably carried by worm migration in the biliary tree. liver sections from both patients showed typical features of hepatic clonorchiasis with the cancer. A knowledge of the wide spectrum of clinical presentation of clonorchiasis, particularly cholangiocarcinoma, might aid Western physicians in averting this serious sequela through prompt eradication of the helminthic infection and early recognition and treatment of its complications.- - - - - - - - - - ranking = 1keywords = cholangiocarcinoma, carcinoma (Clic here for more details about this article) |
4/11. A minute hepatocellular carcinoma found in a liver with clonorchis sinensis infection: report of two cases.Two cases of minute hepatocellular carcinoma (HCC) found in a liver infested with clonorchis sinensis are described. One had mild infestation with hepatic changes suggestive of posthepatitic cirrhosis, and the other heavy infestation exhibiting secondary biliary cirrhosis with dilated intrahepatic bile ducts and periductal fibrosis. None had evidence of hepatitis b infection. The tumor nodule was solitary, measuring 5 X 7 mm and 10 X 11 mm, respectively, and the cells were differentiated to be classified as Grade I of Edmondson-Steiner's scale of anaplasia. It is not clear whether or not clonorchiasis was etiologically related to HCC, but it was of interest that in both cases the tumor nodule was very small representing the primary lesion without metastasis.- - - - - - - - - - ranking = 8.0562214942095E-5keywords = carcinoma (Clic here for more details about this article) |
5/11. Intraductal variant of peripheral cholangiocarcinoma of the liver with clonorchis sinensis infection.Peripheral cholangiocarcinoma arises from the small bile ducts and presents with an infiltrative growth, but intraductal growth in the peripheral large duct tributaries is an extremely unusual manifestation, especially in cases with clonorchis sinensis infection. A case of surgically resected intraductal variant of peripheral cholangiocarcinoma of the liver in a 46-year-old Korean man who had eaten raw fresh-water fish is described. The tumors were entirely confined within the dilated peripheral tributaries of the left intrahepatic bile duct, and no tumorous extension beyond the bile duct walls into the hepatic parenchyma or to the hilum was found. Microscopically, the tumor was a well-differentiated papillary adenocarcinoma of large duct origin, and the major branches were plugged with multiple tumor casts. A histologic feature of a C. sinensis infection with fully developed adenomatous hyperplasia was associated in the peripheral septal ducts, and the nonneoplastic large duct showed focal epithelial dysplasia. The authors assume that intraductal cholangiocarcinoma is a distinct macroscopic subtype, and that a C. sinensis infection may also be responsible for its development.- - - - - - - - - - ranking = 1.1666639812595keywords = cholangiocarcinoma, carcinoma (Clic here for more details about this article) |
6/11. Hilar cholangiocarcinoma associated with clonorchiasis.Pathologic and epidemiologic evidence support the relationship between the liver fluke clonorchis sinensis and the development of bile duct cancer. We report here a case of cholangiocarcinoma in a Laotian immigrant originally diagnosed with clonorchiasis. This case demonstrates the importance of early recognition and treatment of this disease to prevent subsequent morbidity and mortality. Diagnosis and treatment of clonorchiasis as well as the possible modes of cancer induction are discussed.- - - - - - - - - - ranking = 0.83331990629751keywords = cholangiocarcinoma, carcinoma (Clic here for more details about this article) |
7/11. cholangiocarcinoma associated with liver fluke infection: a preventable source of morbidity in Asian immigrants.In the far east infection with the liver flukes clonorchis sinensis and opisthorchis viverrini is the most frequently documented cause of cholangiocarcinoma. liver fluke infection in the united states remains a health problem for more than 500,000 Southeast Asian refugees who have immigrated to this country since 1975. Recent surveys have revealed that up to 26% of Asian immigrants have an active liver fluke infection. However, the common clinical manifestations of this condition, as well as the possibility of developing such long-term sequelae as cholangiocarcinoma, remain unknown to many physicians providing care for this population. This report describes a clinically unsuspected C. sinensis infection associated with cholangiocarcinoma in an elderly Chinese immigrant, and emphasizes the importance of early diagnosis and treatment of all liver fluke infections in the prevention of bile duct neoplasms in high risk populations.- - - - - - - - - - ranking = 0.50005639355046keywords = cholangiocarcinoma, carcinoma (Clic here for more details about this article) |
8/11. Mucoepidermoid carcinoma of the bile duct.Three patients with mucoepidermoid carcinoma of the bile duct are described. In two patients the tumor arose from the common hepatic duct. Mucoepidermoid carcinoma of the extrahepatic bile duct has not been previously reported. The clinical features and pathologic behavior of this rare type of tumor are similar to the usual biliary adenocarcinoma. The coexistence of clonorchis sinensis infestation and primary pyogenic cholangitis raises the possibility of an etiologic association.- - - - - - - - - - ranking = 0.00011278710091893keywords = carcinoma (Clic here for more details about this article) |
9/11. gallbladder adenocarcinoma with gallstone and calcified ova of clonorchis sinensis--a case report.A case of gallbladder adenocarcinoma with gallstone and calcified parasitic ova of clonorchis sinensis was described. The patient, a 58-year-old Chinese woman, presented with general malaise and jaundice. The gallbladder contained 3 stones in addition to the cancerous lesion. Microscopically, we saw calcified parasitic ova of clonorchis sinensis associated with the stones. The relationships between clonorchis sinensis, stones and adenocarcinoma were discussed.- - - - - - - - - - ranking = 9.6674657930514E-5keywords = carcinoma (Clic here for more details about this article) |
10/11. hepatitis b and C virus, clonorchis sinensis for the risk of liver cancer: a case-control study in Pusan, korea.BACKGROUND: liver cancer mortality in korea is the highest in the world. hepatitis b and C viruses (HBV, HCV) are known to be the major risk factors of hepatocellular carcinoma (HCC). cholangiocarcinoma (CLG) accounts for more than 20% of liver cancer in the Pusan area. In korea, the different roles of known risk factors in the development of HCC or CLG have not been adequately evaluated. methods: case-control studies involved 203 incident HCC cases, 406 controls matched to the HCC cases for age ( /- 4 years) and sex, and 41 CLG cases (the HCC controls were used). They were carried out from August 1990 to August 1993. RESULTS: Relative risk (RR) of HBsAg (87.4; 95% confidence interval [CI]: 22.2-344.3) and RR of anti-HCV positivity (30.3; 95% CI: 6.1-150.6) were significant for the risk of HCC after adjustment for potentially confounding factors. In contrast, RR of clonorchis sinensis in stool (2.7; 95% CI: 1.1-6.3) and RR of heavy drinking (4.6; 95% CI: 1.4-15.2) were significant for the risk of CLG. Transfusion history, acupuncture history, and cigarette smoking were not associated with the risk of HCC or CLG. CONCLUSIONS: Strong evidence indicated that both HBV and HCV infection were independent risk factors for HCC. In contrast, C. sinensis in stools and heavy drinking were associated with the risk of CLG in korea.- - - - - - - - - - ranking = 3.2224885976838E-5keywords = carcinoma (Clic here for more details about this article) |
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