1/315. Prolonged lactic acidosis after extended hepatectomy under in situ hypothermic perfusion.A 46-year-old woman underwent right extended hepatectomy under total vascular occlusion with in situ hypothermic perfusion for colorectal metastasis. Immediately after surgery, she developed severe lactic acidosis, which required correction with sodium bicarbonate solution and ventilatory support for 36 hours. After 2 days, her lactate normalized, and the acidosis was corrected. She made an uneventful recovery. Persistent lactic acidosis after major hepatic resection under in situ hypothermic perfusion is a rare but reversible problem.- - - - - - - - - - ranking = 1keywords = colorectal (Clic here for more details about this article) |
2/315. Beneficial treatment of patients with advanced cancer using a newcastle disease virus vaccine (MTH-68/H).newcastle disease virus Vaccine (MTH-68/H) was administered to patients suffering from advanced neoplastic diseases after non-efficient tumor-destructive treatment. case reports of selected patients suggest promising effects of this treatment. A prospectively-randomized clinical study (phase III; in accordance with Good Clinical Practice, GCP) was proposed to confirm these results and is currently under consideration.- - - - - - - - - - ranking = 0.00028898513529677keywords = cancer (Clic here for more details about this article) |
3/315. Colorectal cancer recurrence during pregnancy--unique and poorly understood clinical entity: report of a case.The detection of primary or recurrent colorectal cancer during pregnancy is a rare event. early diagnosis is difficult, because symptoms are often attributed to pregnancy. Here we describe a case of recurrent adenocarcinoma of the colon in a 23-year-old pregnant patient. The relationship between various hormonal and immunological changes of pregnancy and colorectal cancer is discussed.- - - - - - - - - - ranking = 2.226214803172keywords = colorectal, colorectal cancer, cancer (Clic here for more details about this article) |
4/315. Pineal metastasis as first clinical manifestation of colorectal adenocarcinoma. Case report.Cerebral metastases from colorectal adenocarcinomas occur in 8% of the cases. Diagnosis is usually made when primary disease and widespread metastases are already known. We report the case of a patient with single metastases in the pineal region as the first clinical manifestation of a colorectal adenocarcinoma. A 48-year-old female with Parinaud's syndrome for 15 days prior her admission was evaluated in our clinic. She had no symptoms or signs of colorectal disease. MRI examination revealed an heterogeneous lesion with peritumoral gadolinium enhancement, located in the pineal region. The tumor was radically resected through an infratentorial/supracerebellar approach. histology showed metastatic carcinoma and immunohistochemical examination showed gastrointestinal tract adenocarcinoma. Metastases to the pineal region are extremely rare and should be considered in the differential diagnosis of tumors of this region.- - - - - - - - - - ranking = 7keywords = colorectal (Clic here for more details about this article) |
5/315. Fecal occult blood tests in occult gastrointestinal bleeding.Occult gastrointestinal bleeding is diagnosed by using one of the commercially available fecal occult blood tests (FOBTs). guaiac-based slide tests are most frequently used, although the more specific immunochemical methods are promising. The guaiac tests are inexpensive, nonspecific, qualitative measures of stool blood, and their use requires dietary and drug restrictions. Clinicians need to be aware of the causes of false-positive and false-negative test results. Although specific for the presence of human blood, immunochemical tests are more expensive and tend to react also to physiological quantities of blood in fecal specimens. Whichever test is chosen, it must be processed and read correctly. Annual FOBT screening for colorectal cancer, combined with periodic flexible sigmoidoscopy, is a cost-effective method of detecting early, curable colorectal cancer.- - - - - - - - - - ranking = 2.1130351553022keywords = colorectal, colorectal cancer, cancer (Clic here for more details about this article) |
6/315. Colorectal cancer: genetics and screening.Colorectal cancer is a common disease in the western world. Most, if not all, colorectal cancers develop from previously benign adenomas. There are a number of genetic abnormalities including mutations in oncogenes and tumor suppressor genes which either present as a germline, or acquired defects lead to the development of colorectal cancer. Two well-defined hereditary colorectal cancer syndromes exist, hereditary nonpolyposis colorectal cancer syndrome and familial adenomatous polyposis coli, for which genetic testing is possible and advised. Guidelines for screening for colorectal cancer in average, moderate, and high risk patients are available from the american cancer society and were updated in 1997. The American Society of Clinical Oncology has published guidelines for genetic testing in a variety of cancers including colorectal cancer.- - - - - - - - - - ranking = 6.7562472842499keywords = colorectal, colorectal cancer, hereditary nonpolyposis, hereditary nonpolyposis colorectal, nonpolyposis colorectal, hereditary nonpolyposis colorectal cancer, nonpolyposis, nonpolyposis colorectal cancer, cancer (Clic here for more details about this article) |
7/315. Colorectal cancer in adolescents.Colorectal cancer, one of the most common malignancies among adults, is rare in adolescence. This low incidence coupled with non-specific symptoms and aggressive natural history leads to a poorer prognosis than in reported adult series. This article describes two cases of colorectal cancer in adolescents and reviews the literature regarding this rare condition. Earlier diagnosis and a greater understanding of the natural history may lead to improved treatment with concomitant improvements in survival.- - - - - - - - - - ranking = 1.1133241404375keywords = colorectal, colorectal cancer, cancer (Clic here for more details about this article) |
8/315. Colorectal cancer complicating ulcerative colitis: an institutional series.Ulcerative colitis predisposes to colorectal cancer: the risk increases along with disease duration and extension. Also some subsets of patients are at increased risk, namely patients with early onset of colitis, and patients with primary sclerosing cholangitis. Cancer complicating ulcerative colitis affects evenly all the colon, and is not located more frequently in the rectum and in the sigmoid colon, as well as the sporadic counterpart. Multiple cancers and cancers associated with high grade dysplasia are not infrequent in ulcerative colitis; for this reason, and for controlling the colitis, the treatment of choice is total colectomy, with or without colostomy. The prognosis of cancer complicating ulcerative colitis is similar to the sporadic counterpart. The Authors present a colon cancers series as a complication of colitis occurred at Regina Elena Cancer Institute of Rome, italy, over the period 1975-1998.- - - - - - - - - - ranking = 1.1135408792889keywords = colorectal, colorectal cancer, cancer (Clic here for more details about this article) |
9/315. Transanal endoscopic microsurgery for T1 rectal cancer in patients with synchronous colorectal cancer.We treated T1 rectal cancer in three patients with synchronous colorectal cancer by transanal endoscopic microsurgery (TEM) before performing a radical operation for the second lesion. On pathological examination, all rectal specimens resected by TEM showed cancer invasion within the submucosal layer, while the margins of the specimen were completely free of cancerous tissue. Few complications were encountered with either the TEM for the rectal lesions or the succeeding radical operation for the second lesions. When patients present with synchronous colorectal cancer, including T1 rectal cancer, local excision of the rectal lesion via TEM can help to improve the patient's quality of life without affecting the curability of the disease.- - - - - - - - - - ranking = 6.6783554243806keywords = colorectal, colorectal cancer, cancer (Clic here for more details about this article) |
10/315. Mutations of the adenomatous polyposis coli and p53 genes in a child with Turcot's syndrome.Turcot's syndrome is a rare heritable complex that is characterized by an association between a primary neuroepithelial tumor of the central nervous system and multiple colonic polyps. The aim of this study was to analyze genetic alterations in a case of Turcot's syndrome in a 10.5-year-old boy in whom a colorectal tumor developed 3.5 years following astrocytoma. An APC germline non-sense mutation at codon 1284 leading to a truncated protein was identified, as was a somatic p53 mutation in the colorectal carcinoma in exon 7, codon 244. The latter was not identified in the primary astrocytoma. However, immunohistochemistry revealed high p53 protein expression in both tumors, suggesting an additional p53 mutation in the primary astrocytic tumor. The diverse p53 mutations observed in this unique syndrome in two different sites and stages of the disease may shed light on the multistep progression of the malignant events.- - - - - - - - - - ranking = 2keywords = colorectal (Clic here for more details about this article) |
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