1/10. Recurrent episodes of coma: an unusual phenotype of familial hemiplegic migraine with linkage to chromosome 1.Over a period of ten years, a boy had several episodes of coma, lasting three to five days. Each episode was preceded by hemiparesis or paresthesias, aphasia, headaches and behavioural changes, with subsequent loss of consciousness. Partial seizures occurred during the first episode. A history of migraine or hemiplegic migraine was found in several members of the family. Linkage to chromosome 1q21-23, where a gene for familial hemiplegic migraine has been mapped, was shown in this family.- - - - - - - - - - ranking = 1keywords = familial hemiplegic migraine, hemiplegic migraine, migraine (Clic here for more details about this article) |
2/10. Wide clinical variability in a family with a CACNA1A T666m mutation: hemiplegic migraine, coma, and progressive ataxia.We report a Japanese family carrying a T666M missense mutation of CACNA1A. Affected members demonstrated a strikingly wide clinical spectrum including migraine, hemiplegia, coma, and progressive cerebellar ataxia. Despite such variability of the clinical features, they demonstrated similar magnetic resonance imaging findings demonstrating cerebellar atrophy predominantly of the cerebellar vermis. These magnetic resonance images appeared not to correlate with clinical severity. Our findings should indicate that a T666M mutation of CACNA1A may be associated with more variable clinical features and that paroxysmal hemiplegic migraine attacks and progressive cerebellar atrophy should have distinct mechanisms of pathogenesis.- - - - - - - - - - ranking = 0.053711627859049keywords = hemiplegic migraine, migraine (Clic here for more details about this article) |
3/10. Magnetic resonance angiogram evidence of vasospasm in familial hemiplegic migraine.We report a case of familial hemiplegic migraine in an 11-year-old girl who presented with coma and left hemiparesis. magnetic resonance imaging showed reversible vasospasm and evidence of oligemia, bringing new information regarding neurovascular changes in familial hemiplegic migraine.- - - - - - - - - - ranking = 1.1843868192153keywords = familial hemiplegic migraine, hemiplegic migraine, migraine (Clic here for more details about this article) |
4/10. Neuropsychiatric manifestations of defect in mitochondrial beta oxidation response to riboflavin.A 29 year old woman is described with severe hyperemesis gravidarum, atypical migraine, numerous admissions to hospital for psychiatric illness, non-epileptic seizures, and valproate-induced coma. Metabolic studies and measurement of [9,10(n)-3H]palmitate oxidation by cultured fibroblasts suggested a multiple acyl-CoA dehydrogenation disorder. Treatment with riboflavin abolished headaches and abnormal behaviour and normalised the plasma free carnitine level. Subtle defects in mitochondrial beta oxidation may be a treatable cause of disordered behaviour in adults.- - - - - - - - - - ranking = 0.0028358230192991keywords = migraine (Clic here for more details about this article) |
5/10. Opening of the blood-brain barrier preceding cortical edema in a severe attack of FHM type II.The authors report a patient with familial hemiplegic migraine type II who developed a long-lasting attack including fever, right-sided hemiplegia, aphasia, and coma. Quantitative analysis of early gadolinium-enhanced MRI revealed a mild but significant left-hemispheric blood-brain barrier (BBB) opening limited to the cortex and preceding cortical edema. The findings suggest that the delayed cortical edema was vasogenic in the severe migraine aura variant of this ATP1A2 mutation carrier.- - - - - - - - - - ranking = 0.20023362622185keywords = familial hemiplegic migraine, hemiplegic migraine, migraine (Clic here for more details about this article) |
6/10. Recurrent prolonged coma due to basilar artery migraine. A case report.A 25 year old patient presented with recurrent prolonged episodes of life-threatening coma varying from 3 to 10 days. The clinical recovery was slow. The history and technical examinations led to the diagnosis of basilar artery migraine (BAM). The etiology of the coma episodes is thought to be related to ischemic dysfunction of the rostral part of the brainstem due to severe spasm of the basilar artery demonstrated by arteriography. Exceptional are the recurrent prolonged coma episodes of sudden onset, the severe spasm of the basilar artery, and the suppression-burst and FIRDA pattern on the EEG examinations during the coma episodes.- - - - - - - - - - ranking = 0.014179115096496keywords = migraine (Clic here for more details about this article) |
7/10. Familial migraine coma: a case study.A family suffering from a rare malignant type of migraine is described. The syndrome is characterized by episodes of coma with meningitic signs and fever and pareses as well as persistent cerebellar signs. coma attacks last up to several days and can be precipitated by minor head trauma, vigorous work and angiography. From a study of this family and the literature, it is concluded that this syndrome has to be included in the differential diagnosis of coma and that angiography should be avoided in the patients.- - - - - - - - - - ranking = 0.014179115096496keywords = migraine (Clic here for more details about this article) |
8/10. Impairment of consciousness in migraine.A series is reported of 25 subjects with migraine, whose attacks on some occasions involved impairment of consciousness. The disorder did not necessarily involve younger people, or occur early in the course of the malady.- - - - - - - - - - ranking = 0.014179115096496keywords = migraine (Clic here for more details about this article) |
9/10. Migraine coma. Meningitic migraine with cerebral oedema associated with a new form of autosomal dominant cerebellar ataxia.A family with hemiplegic migraine has been documented for a period of over forty years. From this study and the literature we conclude that (1) migraine is a cause of recurrent coma which may be associated with life-threatening cerebral hemisphere oedema; (2) hyperpyrexia with CSF pleocytosis occurs in hemiplegic migraine, which may thus simulate viral meningoencephalitis; and (3) cerebral angiography is hazardous in hemiplegic migraine and may exacerbate coma and cerebral oedema. In the family reported, cerebellar ataxia was present during recovery from attacks of hemiplegic migraine and affected patients ultimately suffered from persistent ataxia with radiological cerebellar atrophy. This syndrome thus constitutes a distinct form of late-onset autosomal dominant cerebellar ataxia and also of familial periodic ataxia. The status of 'cerebellar migraine' is reviewed.- - - - - - - - - - ranking = 0.057715581987595keywords = hemiplegic migraine, migraine (Clic here for more details about this article) |
10/10. Episodic coma due to acute basilar artery migraine: correlation of EEG and brainstem auditory evoked potential patterns.Our patient presented with three episodes of deep coma in 5 weeks, followed by a complete recovery. The neuroradiological tests and spinal fluid analysis excluded structural lesions, including subarachnoid hemorrhage, from the diagnosis. A nonconvulsive status was excluded by 24-hour EEG monitoring. The EEGs and brainstem auditory evoked responses were abnormal during ictus, but they reversed to normal with the clinical recovery. Timely neurophysiological tests helped in the diagnosis of basilar artery migraine.- - - - - - - - - - ranking = 0.014179115096496keywords = migraine (Clic here for more details about this article) |
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