1/6. Orbital inflammatory pseudotumor and ischemic vasculitis in churg-strauss syndrome: report of two cases and review of the literature.OBJECTIVE: To clarify the characteristics of ocular manifestations in churg-strauss syndrome (allergic granulomatosis and angiitis). DESIGN: Two interventional case reports and literature review. PARTICIPANTS: Two patients with churg-strauss syndrome with ocular manifestations are described; 15 previously reported cases and the present 2 cases of churg-strauss syndrome with ocular manifestations are reviewed. INTERVENTION: Ocular manifestations were divided into two groups: orbital inflammatory pseudotumor and ischemic vasculitis. MAIN OUTCOME MEASURES: The onset, conjunctival involvement, orbital imaging, antineutrophil cytoplasmic antibodies (ANCA), and visual prognosis were evaluated. RESULTS: The characteristics of the orbital inflammatory pseudotumor type (eight cases) are chronic onset, positive conjunctival involvement, abnormalities in orbital imaging studies, negative ANCA, and good visual prognosis. The ischemic type (nine cases) is characterized by sudden onset, no conjunctival involvement or abnormalities in imaging studies, positive ANCA, and occasional poor visual prognosis. CONCLUSIONS: Orbital inflammatory pseudotumor and ischemic vasculitis may represent two essential characteristics of churg-strauss syndrome, granulomatosis and angiitis, respectively. The clinical features of the two types are so distinct that differentiation may be meaningful for diagnosis and treatment of churg-strauss syndrome with ocular manifestations.- - - - - - - - - - ranking = 1keywords = vasculitis (Clic here for more details about this article) |
2/6. churg-strauss syndrome presenting with conjunctival nodules in association with candida albicans and ankylosing spondylitis.churg-strauss syndrome is a rare diffuse vasculitis of which the ocular manifestations have been well documented. However, reports of conjunctival involvement in churg-strauss syndrome are scarce. Such a presentation is described in a man with candida albicans infection as well as ankylosing spondylitis, and a possible aetiological linkage is established amongst all three.- - - - - - - - - - ranking = 0.16666666666667keywords = vasculitis (Clic here for more details about this article) |
3/6. Conjunctival involvement in churg-strauss syndrome.A 64-year-old man had slowly progressive thickening of the bulbar and palpebral conjunctiva of the right eye, followed by signs and symptoms of an upper respiratory infection. A biopsy specimen of the conjunctival lesions demonstrated granulomatous inflammation with eosinophils compatible with a diagnosis of churg-strauss syndrome (asthma, eosinophilia, vasculitis, and granulomatous inflammation with eosinophils). Subsequently, fever, shortness of breath, moderate renal failure, and anemia developed. Therapy with systemic corticosteroids and cyclophosphamide was instituted, with resolution of the systemic and ocular manifestations.- - - - - - - - - - ranking = 0.16666666666667keywords = vasculitis (Clic here for more details about this article) |
4/6. Wegener's granulomatosis. Eyelid and conjunctival manifestations as the presenting feature in two individuals.BACKGROUND: Wegener's granulomatosis is a necrotizing granulomatous vasculitis that may exist in a generalized or limited form and has a variety of unusual and uncommon presentations. Although ocular manifestations are relatively common in the disease at some point, the eyelid and its conjunctival lining are rarely involved. When this area is the initial focus of the disease, diagnosis may be difficult. RESULTS: The authors present two patients with Wegener's granulomatosis who had involvement of the palpebral conjunctiva as the initial manifestation. CONCLUSION: Eyelid and conjunctival involvement in Wegener's granulomatosis is uncommon. When it is the initial manifestation of this disease, a diagnosis of Wegener's may be delayed unless this unusual presentation is recognized.- - - - - - - - - - ranking = 0.16666666666667keywords = vasculitis (Clic here for more details about this article) |
5/6. microscopic polyangiitis with ocular involvement.microscopic polyangiitis is an exclusively small-vessel (arterioles, capillaries, or venules) vasculitis that primarily involves the kidney and often involves the lungs, skin, or nervous system. Characteristic features include focal segmental glomerulonephritis, nongranulomatous necrotizing vasculitis, and serum positive for perinuclear-staining antineutrophil cytoplasmic antibodies (P-ANCA). We report a case of microscopic polyangiitis with previously unreported eyelid and conjunctival manifestations that responded well to immunosuppressive therapy.- - - - - - - - - - ranking = 0.33333333333333keywords = vasculitis (Clic here for more details about this article) |
6/6. pterygium with granuloma faciale-like histologic picture.PURPOSE: Description of a case with an atypical conjunctival pterygium with an unusual histologic picture suggesting granuloma faciale, a vasculitis-like disease of facial skin with a chronic, indolent course. Discussion of diagnosis and treatment. methods: Repeated clinical and histologic observations. RESULTS: A pterygium with an unusual nasosuperior localization was excised and examined microscopically. There was a dense vessel-related inflammatory infiltrate, essentially identical to granuloma faciale. The lesion recurred and, as granuloma faciale is amenable to dapsone (diphenyl sulfone), treatment with 100 mg daily resulted in rapid improvement, whereas reduction of the dose to 50 mg daily resulted in relapse. Reinstitution of the original dose resulted in normalization of the histologic picture. However, a recurrent pterygium developed, which had a quite unspecific histologic picture. CONCLUSION: A disease with a histologic picture essentially identical to granuloma faciale may manifest itself as a pterygium. Treatment with dapsone may be beneficial.- - - - - - - - - - ranking = 0.16666666666667keywords = vasculitis (Clic here for more details about this article) |