1/14. Idiopathic conjunctival granulomas.A 12-year-old white boy presented with a 1-year history of intermittent bilateral follicular conjunctivitis with yellowish bulbar and limbal nodules and few symptoms. Histopathological examination of conjunctival biopsy specimens showed non-caseating epithelioid cell granulomas with giant cell formation. The lesions partially responded to therapy with topical corticosteroids but persisted for another 4 years and then gradually cleared over the next 5 years. A systemic investigation failed to disclose a specific cause. At the time of writing, the nodules had completely resolved and no associated systemic disease had developed.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
2/14. Russell bodies in contact-lens-associated giant papillary conjunctivitis.biopsy specimens of the upper tarsal conjunctiva in soft contact lens-associated giant papillary conjunctivitis were taken during (1) chronic exacerbation, (2) brief remission, and (3) intentional exacerbation. Inflammatory cells were quantitated and compared with inflammatory cells in normal upper tarsal conjunctivae. Specimens were evaluated by light and electron microscopy. The most remarkable feature was the presence of diamond-shaped Russell bodies in 20% of the plasma cells of the second biopsy specimen. A few round Russell bodies were seen in the first biopsy specimen and none in the third. We concluded that the brief quiescent phase (second biopsy specimen) was characterized by retention of immunoglobulin to produce Russell bodies, and that the active phases of the disease were marked by migration of mast cells into the epithelium and by the presence of eosinophils and basophils in the substantia propria.- - - - - - - - - - ranking = 5keywords = giant (Clic here for more details about this article) |
3/14. Giant papillary conjunctivitis with ocular prostheses.In seven patients who each had either a methyl methacrylate corneal shell, a postenucleation ocular prosthesis, or a keratoprosthesis, giant papillary conjunctivitis of the tarsus of the upper lids developed after prolonged wear. These cases expand the spectrum of disease that was initally described in wearers of hard and soft contact lenses. The papillary changes in prostheses wearers did not always produce symptoms and were not readily reversible. basophils and mast cells characterized the inflammatory infiltrate, suggestng an antigen-antibody mechanism underlying the response. Increased production of epithelial mucin, in contrast to goblet cell mucin, may play a role in producing symptoms in this syndrome.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
4/14. Giant papillary conjunctivitis and ptosis in a contact lens wearer.A case of ptosis due to giant papillary conjunctivitis in a 24-year-old female is described. The contact lens was removed and the ptosis disappeared. A possible etiology is discussed.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
5/14. Giant papillary conjunctivitis following cataract extraction.Out of a series of 600 cataract extractions, 14 patients were found to have giant papillary conjunctivitis (GPC) due to 10-0 nylon sutures. When renewed conjunctival irritation appears weeks or months after surgery, GPC should be suspected and confirmed by eversion of the upper eyelid at the slit lamp. Free edges of protruding corneoscleral nylon sutures should be looked for. signs and symptoms of GPC disappear within one to four weeks after removal of the offending suture.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
6/14. Transient ptosis secondary to giant papillary conjunctivitis in a hydrogel lens patient.A case of transient ptosis due to GPC in a 14-year-old white female was presented. The hydrogel contact lenses were removed and after 3 days of cold compress management, the ptosis disappeared. After two months of spectacle wear the patient was refitted with hydrogel lenses made from a different material in a different design. In addition the solution regimen was changed to non-preserved saline and thermal disinfection. A review of the GPC literature and pathophysiological mechanism were presented.- - - - - - - - - - ranking = 4keywords = giant (Clic here for more details about this article) |
7/14. mucous membrane grafting for severe palpebral vernal conjunctivitis.Vernal conjunctivitis usually can be managed medically. In the rare cases that do not respond to medical treatment, surgical intervention has been considered. Four cases of vernal conjunctivitis and one case of probable contact lens-induced giant papillary conjunctivitis were treated with palpebral conjunctival excision and application of a mucous membrane graft. All patients improved symptomatically, with follow-up ranging from 1 1/2 to 14 years. The only complication encountered was recurrence of giant papillae at the conjunctiva-mucous membrane graft junction. Conjunctival excision and mucous membrane grafting is a useful procedure in rare cases of particularly severe vernal conjunctivitis.- - - - - - - - - - ranking = 2keywords = giant (Clic here for more details about this article) |
8/14. Suture barb giant papillary conjunctivitis.Giant papillary conjunctivitis can be due to an allergic reaction as in soft contact lens wearers and allergic palpebral conjunctivitis, or can result from a cut exposed suture end that abrades the upper palpebral conjunctiva. The syndrome of suture barb giant papillary conjunctivitis consists of a mucoid ocular discharge with blurred vision, a foreign body sensation, upper lid edema and blepharoptosis concomitant with giant papillae of the upper palpebral conjunctiva. Removal of the offending suture(s) results in resolution of the papillae and symptoms.- - - - - - - - - - ranking = 6keywords = giant (Clic here for more details about this article) |
9/14. Cromolyn treatment of giant papillary conjunctivitis.Five patients with symptomatic giant papillary conjunctivitis were treated with topical cromolyn sodium eyedrops. All patients responded favorably with relief of symptoms. Four of the patients who were subsequently examined while receiving cromolyn therapy had less prominent giant papillae on the upper tarsal conjunctivae. Thus far, the treatment of giant papillary conjunctivitis has been poorly defined and is not always practical. Topical cromolyn eyedrops seem to be helpful in the treatment of this disorder.- - - - - - - - - - ranking = 7keywords = giant (Clic here for more details about this article) |
10/14. Complications of exposed monofilament sutures.Exposed monofilament suture ends caused a variety of symptoms and signs in 18 patients. These included foreign-body sensation, pain, contact lens intolerance, giant papillary conjunctivitis, tarsal ulceration, conjunctival granuloma, corneal infiltrate, and corneal vascularization. These changes followed cataract surgery, corneal transplantation, and pars plana vitrectomy. Diagnoses in these cases were made by careful slit-lamp examination and by eversion of the upper eyelid. In every case, removal of the sutures or trimming the suture ends resulted in the immediate relief of all symptoms with complete resolution of all signs within two months.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
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