1/9. Sweet's syndrome in a patient with acute Crohn's colitis and longstanding ankylosing spondylitis.Acute neutrophilic dermatosis, also referred to as Sweet's syndrome according to the first description in 1964, occurs not only as an isolated phenomenon but also in the context of neoplastic and inflammatory diseases, occasionally including arthritides. Recently Sweet's syndrome has been reported in a small number of patients with chronic inflammatory bowel disease, mostly in advanced stages of the disease. Here, we describe the sudden outbreak of acute neutrophilic dermatosis in coincidence with the onset of severe Crohn's disease (CD) in a patient with long-standing ankylosing spondylitis (AS). This condition has not been described before and therefore Sweet's syndrome should be added to the spectrum of skin manifestations the rheumatologist has to think about in the context of the spondylarthropathies (SpA). Furthermore, this case report is of interest because the skin lesions of Sweet's syndrome are somewhat similar to psoriasis, which is a rather frequent feature of the spondylarthropathies. This article intends to clarify the clinical and histological differentiation between Sweet's syndrome, psoriatic skin lesions and erythema nodosum for the rheumatologist and stresses that these conditions must each be treated in a completely different manner.- - - - - - - - - - ranking = 1keywords = dermatosis (Clic here for more details about this article) |
2/9. Sweet's syndrome in association with Crohn's disease: report of a case and review of the literature.A 41-year-old woman developed a skin rash as part of Sweet's syndrome concurrent with the first episode of Crohn's disease of the colon. Sweet's syndrome, acute febrile neutrophilic dermatosis, may be associated with inflammatory, infectious, or neoplastic diseases. Its association with Crohn's disease is very rare, and when reported it has been mainly associated with Crohn's colitis. This association has been described in various stages of the disease. Sweet's syndrome may be considered one of the extraintestinal manifestations of Crohn's disease. early diagnosis of this dermatosis may be important because of the prompt response to treatment with corticosteroids. The value of metronidazole should be considered because this medication may enhance response to treatment.- - - - - - - - - - ranking = 1keywords = dermatosis (Clic here for more details about this article) |
3/9. A continuous spectrum of neutrophilic dermatoses in Crohn's disease.The inflammatory bowel disease is accompanied by cutaneous manifestations in approximately 10% of the cases. Neutrophilic dermatoses are located on the dermis and/or epidermis and are characterised on histological examination by the presence of an infiltrate that consists largely of neutrophils. The prototype of neutrophilic dematoses is Sweetacute;s syndrome; which is rarely associated with Crohns disease. CASE REPORT: A 63 year old woman was admitted to hospital with pyrexia, abdominal pain, episcleritis and skin lesions. She presented erythematous lesions on trunk, legs and arms, with tendency towards formation of plaques, nodules and vesicular pustular lesions. Both the colonoscopy and colonic biopsies confirmed the diagnosis of colonic Crohns disease. Cutaneous biopsies re-vealed an infiltrate consisting mainly of neutrophils. These biopsies, together with clinical details led to the diagnosis of Sweetacute;s syndrome. A methylprednisolone treatment rapidly improved the skin lesions and clinical symptoms. The different clinical forms of neutrophilic dermatosis are an extra intestinal manifestation of Crohns disease, and are some-times found concurrently in the same patient, which would indicate a common pathogenesis with different clinical presentations (spectrum of neutrophilic dermatoses).- - - - - - - - - - ranking = 0.5keywords = dermatosis (Clic here for more details about this article) |
4/9. Subcorneal pustular dermatosis in a patient with Crohn's disease.A case of subcorneal pustular dermatosis (Sneddon-Wilkinson disease) is reported in a patient with a one-year history of Crohn's disease. Subcorneal pustular dermatosis has been described in association with monoclonal gammopathy, but to our knowledge it has not been associated with Crohn's disease. This new association reinforces the hypothesis of a possible common pathogenesis for neutrophilic dermatoses and inflammatory bowel diseases.- - - - - - - - - - ranking = 3keywords = dermatosis (Clic here for more details about this article) |
5/9. ofloxacin induced Sweet's syndrome in a patient with Crohn's disease.Sweet's syndrome is an acute febrile neutrophilic dermatosis. This syndrome can be idiopathic, para-inflammatory, paraneoplastic, drug-induced, or pregnancy-related. In this paper, a case of Sweet's syndrome associated with ofloxacin therapy in a patient with Crohn's disease is reported.- - - - - - - - - - ranking = 0.5keywords = dermatosis (Clic here for more details about this article) |
6/9. A case report of acute febril neutrophilic dermatosis (Sweet's syndrome) and Crohn's disease.A case of Crohn's disease complicated by Sweet's syndrome is presented. The main ultrastructural findings were the multiplication of basal lamina surrounding the venulea, interendothelial gaps and in perivascular locations mixed infiltrates of neutrophiles and erythrocytes. The changes indicate that the initial site of the reaction was the walls of the dermal vessels.- - - - - - - - - - ranking = 2keywords = dermatosis (Clic here for more details about this article) |
7/9. The bowel-associated dermatosis--arthritis syndrome.A 46 year old man with Crohn's disease developed a widespread pustular eruption associated with intermittent fever and arthritis. Histological examination demonstrated cutaneous vasculitis with leukocytoclasia, and IgM and C3 on direct immunofluorescence. This is characteristic of the bowel-associated dermatosis-arthritis syndrome, also known as the bowel bypass syndrome without bypass, a recently described complication of inflammatory bowel disease. This is the ninth case reported to date.- - - - - - - - - - ranking = 2.5keywords = dermatosis (Clic here for more details about this article) |
8/9. Oral metronidazole, an effective treatment for Sweet's syndrome in a patient with associated inflammatory bowel disease.A 39-year-old woman with chronic, recurrent Sweet's syndrome (acute febrile neutrophilic dermatosis) and possible Crohn's disease was successfully treated with oral metronidazole. After 4 years of recurrent skin lesions which involved the hands and face, our patient developed genital and perianal ulcerations which were also histopathologically characterized by a neutrophilic infiltrate. In addition, she had a nondeforming polyarthritis that accompanied recurrences of her skin lesions. The patient was given oral metronidazole, an agent frequently used for perianal Crohn's disease, and achieved complete resolution of the perianal and perineal ulcers, the cutaneous lesions of Sweet's syndrome and the associated polyarthritis.- - - - - - - - - - ranking = 0.5keywords = dermatosis (Clic here for more details about this article) |
9/9. Recurrent Sweet's syndrome in reactivated Crohn's disease.A 50-year-old woman developed an acute febrile dermatosis on two occasions concurrently with recurrent Crohn's disease of the colon. Based on the presence of painful erythematous plaques on both hands and forearms, on the leukocytosis with excess bands in peripheral blood, on the histology showing dermal infiltration by mature granulocytes, and on the prompt response to steroids, the diagnosis was made of Sweet's syndrome associated with Crohn's disease. Sweet's syndrome is thought to be a hypersensitivity reaction that leads to parainflammatory (e.g., infections, autoimmune disorders, vaccinations) and paraneoplastic (myeloproliferative disorders, solid malignancy) associations, with a frequency of 10-30%. The association of Sweet's syndrome with Crohn's disease is very rare, but the gastroenterologist should readily differentiate it; it is important to be aware that such patients may have a nonspecific elevated activity index owing to the underlying dermatosis.- - - - - - - - - - ranking = 1keywords = dermatosis (Clic here for more details about this article) |