1/9. risk of malignancy in serous cystic neoplasms of the pancreas.BACKGROUND: In contrast to mucinous cystic neoplasms of the pancreas, which are known to have considerable malignant potential, the serous variant is generally thought to be benign. There are, however, several reports of malignancy in serous cystic neoplasms of the pancreas. AIMS: To assess the risk of malignancy of serous cystic tumors of the pancreas and to investigate specific clinical and histological features. methods: Clinical and pathological characteristics of benign and malignant serous cystic neoplasms of the pancreas were investigated by a review of the literature and documented by a case of a serous cystadenocarcinoma and immunohistochemical analysis of a series of serous cystadenomas. Reviewing the literature prevalence, age and sex distribution of serous cystic neoplasms were analyzed. RESULTS: The prevalence of cancer among serous cystic neoplasms reported since 1989 was 3%. Serous cystadenoma of the pancreas present at an earlier age (61 years) than serous cystadenocarcinoma (66 years; p = 0.056) and are symptomatic in the majority of patients.Pathological examination of the primary tumor was not able to distinguish cystadenoma from cystadenocarcinoma in 38% of cases. In 25% the diagnosis of cancer was established only after growth of metachronous metastases. In the present case, nuclear atypia, papillary structures, proliferation marker Ki-67 and p53 protein were increased in the primary tumor and/or metachronous metastasis. CONCLUSION: Serous cystic neoplasms of the pancreas do have malignant potential with a risk of malignancy of 3% and should be surgically treated if the operative risk is acceptable. Routine analysis of genetic and proliferation markers may improve diagnosis of malignancy in these tumors.- - - - - - - - - - ranking = 1keywords = cystadenoma (Clic here for more details about this article) |
2/9. Malignant serous cystic neoplasm of the pancreas: report of a case and review of the literature.BACKGROUND: In general, serous cystic neoplasms of the pancreas are thought to be benign. Malignant serous cystic neoplasm of the pancreas is a rare clinical entity. CASE REPORT: We report the case of an 87-year-old woman with a serous microcystic neoplasm in the tail of the pancreas that behaved in a malignant fashion. The neoplasm had also invaded the colonic mesentery and splenic hilum. The pancreatic lesion was diagnosed as a large malignant serous cystic neoplasm, and the patient underwent distal pancreatectomy with splenectomy and segmental colectomy. The resected specimen contained a large tumor, 12 x 9 x 8 cm, which occupied the body and tail of the pancreas. Histologically, the tumor was indistinguishable from serous cystadenoma. However, the tumor had invaded surrounding tissues including the splenic vein, and there were splenic invasion and a regional lymph node metastasis. The postoperative course was uneventful. DISCUSSION: There are few reported cases of malignant serous cystic neoplasm, in which malignancy was histologically confirmed in the resected specimen. There are no reports of a negative outcome with complete resection of the tumor. Surgical treatment should be considered for serous cystic neoplasms, especially large ones, because of the malignant potential.- - - - - - - - - - ranking = 0.33333333333333keywords = cystadenoma (Clic here for more details about this article) |
3/9. Serous cystadenocarcinoma of the pancreas.A case of serous cystadenocarcinoma of the pancreas in an 85-year-old woman is reported. The tumor extensively involved the body and tail of the pancreas and contiguously invaded the spleen. The histopathology of the tumor was similar to that of serous cystadenoma, but mild nuclear hyperchromatism and atypism were noted, and the neoplastic invasion of nerve fibers in the stroma was observed. In the spleen neoplastic cells forming microcysts were diffusely insinuated in the red pulp without the fibrous stroma. The patient is in good health without recurrence and metastasis after the operation. The present case is the second example of this kind of neoplasm that showed direct splenic invasion. Because serous cystadenocarcinoma of the pancreas exhibits bland cytological features, diligent search for the invasion of the surrounding tissue or peripheral nerves is needed for the differentiation from its benign counterpart.- - - - - - - - - - ranking = 0.33333333333333keywords = cystadenoma (Clic here for more details about this article) |
4/9. Serous cystadenocarcinoma of the pancreas: management of a rare entity.Whereas mucinous cystadenomas of the pancreas are considered premalignant, serous cystadenomas are believed to remain benign. We present a case of an 80-year-old woman with a primary tumor of the pancreas that was histologically classified as serous cystadenocarcinoma. Because preoperatively available criteria that determine malignancy in serous lesions are lacking, observation is the preferred option in serous cystadenomas. Operating every serous lesion is not justified. Reviewing all reports of serous cystadenocarcinomas that have been published to date, we are providing recommendations for the management of this rare entity.- - - - - - - - - - ranking = 1keywords = cystadenoma (Clic here for more details about this article) |
5/9. Serous cystadenoma of borderline malignancy arising in a parovarian paramesonephric cyst.BACKGROUND: Borderline parovarian tumors are found incidentally at surgery or autopsy. They are extremely rare. The majority have been reported in young women and rarely are they large enough to be clinically significant. CASE: A 53-year-old multiparous female with a symptomatic paraovarian serous borderline cystadenoma is presented. DISCUSSION: The clinical aspects and subsequent management of related cases are discussed.- - - - - - - - - - ranking = 1.6666666666667keywords = cystadenoma (Clic here for more details about this article) |
6/9. Macrocystic serous cystadenoma of pancreas--a case report.The macrocystic variant of serous cystadenomas of the pancreas has only recently been described. We present a case of a 40 year-old female, who presented with vague indigestion. The cyst was unilocular, and was lined by simple cuboidal, ciliated serous type epithelium. Fine needle aspiration, immunohistochemical, light microscopic, and electron microscopic studies are discussed.- - - - - - - - - - ranking = 1.6666666666667keywords = cystadenoma (Clic here for more details about this article) |
7/9. Successful pregnancy in a patient with pseudomyxoma peritonei arising from ovarian mucinous cystadenocarcinoma treated with cisplatin.A 24-year-old Japanese woman clinically showing pseudomyxoma peritonei arising from ovarian mucinous cystadenocarcinoma FIGO stage Ic is reported. She received intra-abdominal administrations of cisplatin five times following left oophorectomy. After being free of disease for 6 months, she conceived and carried two pregnancies to successful deliveries at 34 and 37 weeks, respectively. At the Cesarean sections, there were no abnormal findings except for right ovarian mucinous cystadenoma. She has had no evidence of recurrence by the time of the 60-month postoperative examination.- - - - - - - - - - ranking = 0.33333333333333keywords = cystadenoma (Clic here for more details about this article) |
8/9. Serous cystadenocarcinoma of the pancreas.The mucinous type of cystadenoma of the pancreas is known to have malignant potential, whereas the serous type is believed to be benign. Therefore, the therapeutic strategies for serous cystadenomas are less aggressive than in mucinous cystadenoma, where complete operative resection is the procedure of choice. A patient with a biopsy-proven serous cystadenocarcinoma with a lymph node metastasis is reported. Considering the reported case and a review of the literature, the origin of serous cystadenocarcinoma appears to be from cystadenoma lesions. Even if this development of cystadenocarcinoma in pre-existing serous cystadenoma lesions is a rare entity, a less aggressive treatment of this lesion should be avoided in favor of resection procedures because of the good chance of cure.- - - - - - - - - - ranking = 1.6666666666667keywords = cystadenoma (Clic here for more details about this article) |
9/9. Incidental detection of cystic neoplasms of the pancreas.Cystic neoplasms of the pancreas are rare, accounting for less than 1% of all pancreatic tumors Since the advent of computerized tomography (CT), an increasing number of these lesions are being discovered incidentally. Compagno and Oertel were the first to thoroughly describe and differentiate the benign serous cystadenoma from the potentially or overtly malignant mucinous cystadenoma/cystadenocarcinoma spectrum. At present, our ability to definitively differentiate between these two classes of cystic neoplasms is limited. Because of this, controversy exists as to their appropriate surgical management. A case report is presented and followed by a review of the literature on incidentally detected cystic neoplasms of the pancreas.- - - - - - - - - - ranking = 0.66666666666667keywords = cystadenoma (Clic here for more details about this article) |