1/7. Progressive symmetric erythrokeratodermia.Progressive symmetric erythrokeratodermia is a rare disorder of keratinization manifested by hyperkeratotic plaques on an erythematous base. Familial cases have not been reported. The following is, to our knowledge, the first report of a case from America, as well as the first involving a black child.- - - - - - - - - - ranking = 1keywords = black (Clic here for more details about this article) |
2/7. Erythroderma as the initial presentation of the acquired immunodeficiency syndrome.A 32-year-old black homosexual man, seronegative for human immunodeficiency virus antibody, presented with erythroderma. His peripheral blood was significant for circulating Sezary-like cells bearing the CD8( ) phenotype. Eighty-eight percent of his lymphocytes were CD8( ) as well. He seroconverted 3 months after the initial presentation. We conclude that erythroderma was the presenting sign of the acquired immunodeficiency syndrome.- - - - - - - - - - ranking = 1keywords = black (Clic here for more details about this article) |
3/7. allopurinol hypersensitivity. A case report.The allopurinol hypersensitivity syndrome is a rare adverse drug reaction. It usually occurs in patients with impaired renal function or when allopurinol is prescribed with a thiazide diuretic. The recognition of the characteristic features of the syndrome is vital since early aggressive therapy is indicated. A case of allopurinol hypersensitivity, possibly the first in a black African, is reported.- - - - - - - - - - ranking = 1keywords = black (Clic here for more details about this article) |
4/7. sezary syndrome with arthropathy. Report of a case.A 65-year-old black female with sezary syndrome had generalized intractable pruritus, erythroderma, alopecia, onychogryphosis, lumphadenopathy and hepatomegaly. Abnormal lymphocytes with large, convoluted and grooved nuclei (Sezary cells) were identified in the skin and peripheral blood. A striking feature of her disease was severe, deforming arthropathy of the hands and knees, a clinical finding which has been described previously in only one patient with sezary syndrome. At necropsy no associated lymphoma was found.- - - - - - - - - - ranking = 1keywords = black (Clic here for more details about this article) |
5/7. Boric acid poisoning.The skin manifestations associated with boric acid intoxication are particularly striking. We present a case report of a 44-year-old black woman who, following a suicide attempt, demonstrated the classic features of acute boric acid poisoning. She developed generalized erythema creating a "boiled lobster" appearance with massive areas of desquamation. A discussion of the history of the use of boric acid by the medical profession follows the patient presentation.- - - - - - - - - - ranking = 1keywords = black (Clic here for more details about this article) |
6/7. Generalized vitiligo after erythroderma.We report a 65-year-old black man whose onset of an erythroderma was followed in 6 weeks by a generalized vitiligo. The etiology of the erythroderma was unclear, although a prostate adenocarcinoma was found on evaluation. This is to our knowledge the first patient reported with a vitiligo following exfoliative dermatitis, and the first report of two uncommon markers of internal malignancy (erythroderma and vitiligo) occurring with prostate adenocarcinoma in the same patient.- - - - - - - - - - ranking = 1keywords = black (Clic here for more details about this article) |
7/7. Lichenoid erythrodermic bullous pemphigoid of the African patient.BACKGROUND: lichen planus (LP) pemphigoides is defined by the concurrence of bullous pemphigoid (BP) and LP lesions. However, other autoimmune bullous skin diseases such as paraneoplastic pemphigus or bullous lupus erythematosus may also be associated with lichenoid eruptions. OBJECTIVE: Our purpose was to describe 3 African patients with a similar form of lichenoid erythrodermic BP. methods: medical records of the 3 patients were reviewed for clinical, histologic, and biologic data. The ultrastructural localization of autoantibody deposits was studied by direct and indirect immunoelectron microscopy. The antigenic specificities recognized by the patients' sera were analyzed by immunoblotting on human epidermal extracts. RESULTS: Three black African men had a severe lichenoid erythroderma associated with BP lesions involving the skin and mucosa. Histologic and direct immunofluorescence examination of skin and mucosal lesions were consistent with the diagnosis of BP associated with a lichenoid dermatitis. Immunoblot analysis of sera detected anti-BPAG1 and anti-BPAG2 antibodies and immunoelectron microscopy showed IgG deposits localized in the lamina lucida and the hemidesmosomes. The 3 patients were natives of an area near the senegal River and had the common HLA-DR10 haplotype. CONCLUSION: The clinical and histologic features of these 3 patients were distinct from classic LP pemphigoides. Their common geographic origin and the presence of the HLA-DR10 haplotype suggest that these cases represent a particular type of lichenoid erythrodermic BP, which is probably determined by genetic factors.- - - - - - - - - - ranking = 1keywords = black (Clic here for more details about this article) |