1/50. Drug-induced linear iga bullous dermatosis probably induced by furosemide.linear iga bullous dermatosis (LABD) is an autoimmune disease, characterized by linear deposition of IgA along the basement membrane zone. Drug-induced LABD is rare but increasing in frequency. A new case of drug-induced LABD associated with the administration of furosemide is described.- - - - - - - - - - ranking = 1keywords = membrane (Clic here for more details about this article) |
2/50. stevens-johnson syndrome-like exanthema secondary to methotrexate histologically simulating acute graft-versus-host disease.A 61 year old male patient suffering from psoriasis vulgaris developed a severe skin reaction with toxic myelosuppression three days after administration of 20 mg methotrexate (MTX) p.o. per week and concomitant 100 mg acetylic salicylic acid (ASA) per day. The skin lesions simulated stevens-johnson syndrome with ulcerations of the oral mucosa and erythema multiforme-like target lesions. The histology of the epidermis resembled an acute graft-versus-host reaction. The increased toxic effect of MTX on keratinocytes in our patient was most likely caused by a lowered plasma binding capacity and reduced renal excretion of MTX due to concomitant administration of ASA. Thus in the treatment of severe forms of psoriasis with MTX, the combined administration of drugs aggravating MTX toxicity, particularly of ASA, should be carefully considered, due to the increased toxicity and risk of severe skin reactions.- - - - - - - - - - ranking = 5.7396031512026keywords = mucosa (Clic here for more details about this article) |
3/50. Oral mucosal lichenoid reaction to sulfamethoxazole.A clinical case of oral mucosal lichenoid reaction to sulfamethoxazole in a dental patient with complicating medical conditions is described. Although the relationship between oral mucosal lichenoid reaction and sulfa drugs has not been documented previously, the patient's lichenoid reaction corresponded with sulfamethoxazole use, and improved when the drug was discontinued. Reactions of this type should be monitored so that treatment and preventive measures may be instituted.- - - - - - - - - - ranking = 34.437618907216keywords = mucosa (Clic here for more details about this article) |
4/50. Serious adverse events attributed to nevirapine regimens for postexposure prophylaxis after hiv exposures--worldwide, 1997-2000.In September 2000, two instances of life-threatening hepatotoxicity were reported in health-care workers taking nevirapine (NVP) for postexposure prophylaxis (PEP) after occupational human immunodeficiency virus (hiv) exposure. In one case, a 43-year-old female health-care worker required liver transplantation after developing fulminant hepatitis and end-stage hepatic failure while taking NVP, zidovudine, and lamivudine as PEP following a needlestick injury (1). In the second case, a 38-year-old male physician was hospitalized with life-threatening fulminant hepatitis while taking NVP, zidovudine, and lamivudine as PEP following a mucous membrane exposure. To characterize NVP-associated PEP toxicity, CDC and the food and Drug Administration (FDA) reviewed MedWatch reports of serious adverse events in persons taking NVP for PEP received by FDA (Figure 1). This report summarizes the results of that analysis and indicates that healthy persons taking abbreviated 4-week NVP regimens for PEP are at risk for serious adverse events. Clinicians should use recommended PEP guidelines and dosing instructions to reduce the risk for serious adverse events.- - - - - - - - - - ranking = 166.01854333818keywords = mucous membrane, membrane (Clic here for more details about this article) |
5/50. linear iga bullous dermatosis induced by atorvastatin.linear iga bullous dermatosis (LABD) is an autoimmune blistering skin disease characterized by circulating IgA antibodies binding the basement membrane zone. In most cases the origin is not clear, but in a minority of cases LABD is drug induced. We describe a patient in whom linear IgA disease developed shortly after beginning therapy with atorvastatin. In Western blotting analysis we detected IgA and IgG class antibodies targeting a 97-kd protein. To our knowledge this is the first reported case of atorvastatin-induced LABD.- - - - - - - - - - ranking = 1keywords = membrane (Clic here for more details about this article) |
6/50. Successful combination therapy--flunarizine, pentoxifylline, and cholestyramine--for spur cell anemia.Spur cell anemia, a hemolytic anemia observed in patients with alcoholic cirrhosis, is characterized by unusual erythrocyte morphology and an increased ratio of free cholesterol to phospholipid in the erythrocyte membrane. The prognosis of spur cell anemia is usually extremely poor, however, we describe here a patient with spur cell anemia who was successfully treated with combination therapy consisting of flunarizine, pentoxifylline, and cholestyramine. Initial therapy with flunarizine alone for 6 weeks did not significantly decrease the number of spur cells on peripheral blood smears. So pentoxifylline was added to the regimen. The patient recovered from the anemia, showed remarkable improvement with regard to the hyperbilirubinemia, and the changes were accompanied by a significant decrease in the number of spur cells in peripheral blood smears. To correct the hypercholesterolemia, cholestyramine was added to the regimen, which resulted in a reduction in the serum level of free cholesterol and an increase in the molar ratio of free cholesterol to phospholipid in erythrocyte membrane. However, 6 months later a skin eruption developed that was considered an adverse reaction to the drugs, so the flunarizine and pentoxifylline were discontinued. With cholestyramine therapy alone, the remission of spur cell anemia was maintained for more than 11 months. These observations suggest that non-invasive combination therapy with flunarizine, pentoxifylline, and cholestyramine is effective and valuable in the treatment of patients with spur cell anemia.- - - - - - - - - - ranking = 2keywords = membrane (Clic here for more details about this article) |
7/50. linear iga bullous dermatosis associated with vancomycin and disseminated varicella-zoster infection.linear iga bullous dermatosis (LABD) is characterized by linear deposits of IgA at the basement membrane zone. Most cases are idiopathic, but medications, infections, autoimmune disorders, and malignancies have been documented as potential inducers. We report a case where both vancomycin and varicella-zoster infection were present as triggers.- - - - - - - - - - ranking = 1keywords = membrane (Clic here for more details about this article) |
8/50. vancomycin-induced linear IgA disease with autoantibodies to BP180 and LAD285.Linear IgA disease (LAD) is an acquired autoimmune subepidermal bullous disease characterized by the linear deposition of IgA at the basement membrane zone. A minority of cases are induced by drugs, of which the most frequently implicated is vancomycin. The target antigens in idiopathic LAD are heterogeneous, but have not previously been reported in vancomycin-induced LAD. We report three cases, and in two of these we investigated the target antigens. In both we identified IgA antibodies to LAD285 and IgA and IgG antibodies (dual response) to BP180.- - - - - - - - - - ranking = 1keywords = membrane (Clic here for more details about this article) |
9/50. linear iga bullous dermatosis occurring after carbamazepine.linear iga bullous dermatosis (LABD) is an immunobullous disorder in which IgA antibodies are deposited within the basement membrane zone. The cause is unknown, but the eruption may occur in association with certain medications. We report a patient who experienced LABD shortly after starting carbamazepine therapy.- - - - - - - - - - ranking = 1keywords = membrane (Clic here for more details about this article) |
10/50. Bullous skin disease: an unusual allergic reaction to vancomycin.Severe reactions due to vancomycin are uncommon. We describe a case of vancomycin-induced linear immunoglobulin a bullous disease and review the literature pertinent to this entity. This is a rare subepidermal blistering disorder, with a heterogenous clinical presentation. It is characterized by IgA deposition in a linear pattern along the basement membrane zone. It seems to be autoantibody-mediated and is not dose-dependent. Spontaneous and complete skin healing follows vancomycin withdrawal; rechallenge reproduces the disease with a more rapid and severe onset. Because vancomycin is almost never suspected to be the cause of such manifestations, awareness of this rare autoimmune reaction is crucial. early diagnosis through direct immunofluorescence of the perilesional skin would avoid unnecessary laboratory investigations and therapeutic measures and would shorten significantly the pain and suffering of these patients.- - - - - - - - - - ranking = 1keywords = membrane (Clic here for more details about this article) |
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