1/9. Focal necrotizing endometritis: a clinicopathologic study of 15 cases.From routine sign-out of endometrial biopsy specimens, a group of 15 endometria were identified that have a characteristic histologic pattern of inflammation that is not included in present classifications of endometritis. All but one of the women were premenopausal, and all presented with abnormal vaginal bleeding. The lesion is characterized by a patchy, focal inflammation, usually composed of lymphocytes with a variable number of neutrophils and rare macrophages centered around endometrial glands and extending into the glandular lumen with disruption and partial or subtotal necrosis of the endometrial glandular epithelium. These foci were widely dispersed, never confluent, and could be overlooked easily. plasma cells were not found in any of the endometrial specimens despite methyl green pyronine staining of the samples. Based on the histologic characteristics of this process we have designated it focal necrotizing endometritis. The clinical significance, if any, of focal necrotizing endometritis is currently unknown.- - - - - - - - - - ranking = 1keywords = inflammation (Clic here for more details about this article) |
2/9. Necrotizing granulomatous inflammation of the uterine body following diathermy ablation of the endometrium.A case of necrotizing granulomatous inflammation around the uterine cavity following hysteroscopic diathermy ablation of the endometrium is reported. This is believed to be only the fourth reported case of this condition.- - - - - - - - - - ranking = 2.5keywords = inflammation (Clic here for more details about this article) |
3/9. Pneumopolycystic endometritis.Emphysematous inflammations of the abdomen and pelvis are uncommon and potentially life-threatening conditions that require aggressive treatment. Pneumopolycystic endometritis is a rare benign condition of which only 1 case has been described. This report describes the sonographic and histologic appearance of pneumopolycystic endometritis in a 49-year-old woman who presented with irregular menses and hypermenorrhea of 1 year's duration. The entity is characterized by gas-filled cysts in the endometrium stroma, in a pattern similar to pneumatosis of the vagina. The histologic picture is specific and should not be confused with gas gangrene involving the uterus characterized by the presence of tissue necrosis and life-threatening infection. Our patient is the first documented case that occurred spontaneously and at the same time was limited to the endometrium. Recognition of pneumopolycystic endometritis is important because this condition does not represent an aggressive life-threatening infection, and spontaneous resolution is to be expected.- - - - - - - - - - ranking = 0.5keywords = inflammation (Clic here for more details about this article) |
4/9. Lethal outcome in xanthogranulomatous endometritis.Xanthogranulomatous inflammation is rare, mainly involving the kidneys, while primary xanthogranulomatous endometritis (XE) is a very unusual finding, histologically characterized by partial or complete replacement of the mucosa by granulation tissue with an abundance of foamy histiocytes, siderophages and multinucleated giant cells. We present the case of a 69-year-old woman with a short history of abdominal pain and a palpable mass in the pouch of Douglas. dilatation of the cervix drained a pyometra. Histological examination of the curettage rendered the diagnosis of XE. Microbiological studies revealed enterococcus spp. and peptostreptococcus magnus. Despite antibiotic treatment the patient died of heart failure due to systemic inflammation. autopsy confirmed the diagnosis of XE with transmural extension into the peritoneal cavity. Such a lethal course of XE is extraordinary. Proposed causes of XE include obstruction, infection and hemorrhage. Demonstration of enterococcus spp. and P. magnus supports the probable significance of bacteria in the development of XE. Because this condition may mimic malignant disease macroscopically and histologically, knowledge of XE is of major importance for both pathologists and gynecologists.- - - - - - - - - - ranking = 1keywords = inflammation (Clic here for more details about this article) |
5/9. Uterine herpes virus infection with multifocal necrotizing endometritis.A case of herpes simplex virus (HSV) infection was diagnosed by biopsy of the cervix and endometrium in a 28-year-old woman with abnormal uterine bleeding. The cervical biopsy demonstrated surface ulceration and underlying patchy necrosis of endocervical clefts and stroma. The endometrium was late secretory, with striking patchy necrosis of gland epithelium and stromal cells. Both sites contained occasional epithelial and stromal cells with nuclear inclusions consistent with HSV infection. Viral culture further confirmed the presence of HSV. immunohistochemistry demonstrated the presence of HSV antigens in the tissue, and ultrastructural study of the endometrium revealed viral particles within epithelial and stromal cells. The results suggest endometrial involvement via an ascending infection from the cervix. Recognition of this unusual pattern of endometrial inflammation may facilitate diagnosis of additional cases.- - - - - - - - - - ranking = 0.5keywords = inflammation (Clic here for more details about this article) |
6/9. Isolation of gardnerella vaginalis in pure culture from the uterine cavity of patients with irregular bleedings.hysterectomy was performed in three patients because of persistent irregular vaginal bleeding. Before the operation samples were taken from the cervical os for cultivation of gardnerella vaginalis, yeasts, viruses, chlamydia trachomatis, and aerobic and anaerobic bacteria. Immediately after the operation, the uterus was opened under sterile conditions and samples obtained from the isthmus and fundus of the uterine cavity were examined microbiologically. In all three patients G. vaginalis was grown in pure culture from the fundus. serum antibody titres against G. vaginalis were significantly raised in all three patients, and histology revealed mononuclear cells in the endometrium. The isolation of G. vaginalis from the endometrium of patients with clinical and histological signs of inflammation and with antibodies to G. vaginalis in serum indicates that the organism may play a causative role in endometritis.- - - - - - - - - - ranking = 0.5keywords = inflammation (Clic here for more details about this article) |
7/9. endometritis related to chlamydia trachomatis infection.A 23-year-old woman had endometritis due to chlamydia trachomatis infection. chlamydia trachomatis was cultured from endometrial tissue obtained by biopsy, and elevated levels of serum antibodies, including IgM antibodies, to C. trachomatis were found. Cervical secretions were also positive for antibody. After treatment with tetracycline, endometrial cultures for C. trachomatis were negative and endometrial inflammation disappeared. chlamydia trachomatis has been implicated in salpingitis, cervicitis, urethritis, and peritonitis, This case shows that endometritis may also result from C. trachomatis infection and in such instances may be a contributing factor in infertility.- - - - - - - - - - ranking = 0.5keywords = inflammation (Clic here for more details about this article) |
8/9. Subacute staphylococcal meningitis secondary to postpartum endometritis.A woman with staphylococcus aureus meningitis following postpartum endometritis presented with lumbar backache and fever of several weeks' duration. Thick, green exudate was aspirated at lumbar puncture hours before death. Histologic examination demonstrated subacute inflammation of the meninges and chronic inflammation of the endometrium. Although rare, postpartum endometritis followed by low back pain and fever should alter the physician to the possibility of serious infection involving the central nervous system. diagnosis and treatment at this early stage would be expected to decrease mortality.- - - - - - - - - - ranking = 1keywords = inflammation (Clic here for more details about this article) |
9/9. Intramembranous localization of bacteria in beta-hemolytic group B streptococcal chorioamnionitis.An unusual pathologic finding consisting of large colonies of bacteria, localized immediately beneath the epithelial layer of the amnion, has been observed in association with an example of group B beta-hemolytic streptococcal chorioamnionitis. Postpartum endometritis as well as neonatal sepsis and meningitis occurred. Histologic examination of the umbilical cord and placenta revealed routine features of intraamniotic inflammation, but the membranes were characterized by the presence of unusual darkly staining deposits of material immediately beneath the amniotic epithelium. Subsequent special stains revealed these to be colonies of gram-positive cocci. We have been unable to find a previous description of this observation in association with streptococcal or with other types of chorioamnionitis.- - - - - - - - - - ranking = 0.5keywords = inflammation (Clic here for more details about this article) |