1/28. Eosinophilic cellulitis (Well's syndrome): a new case description.BACKGROUND: Wells' syndrome was first described by Wells in 1971 as a recurrent granulomatous dermatitis with eosinophilia and was later named eosinophilic cellulitis. It is defined by the following criteria: (i) sudden onset of annular or circinate erythematous-edematous patches that rapidly evolve to morphea-like blue-slate-colored plaques; (ii) a histological picture usually characterized by the presence of 'flame figures'; (iii) non-constant blood hypereosinophilia. methods: We describe the case of a 49-year-old woman who reported the sudden appearance of a few hard, pasty, oval-shaped, reddish-violet, moderately itchy, erythematous-edematous patches on both arms about 2 months before our observation. RESULTS: The remote pathologic history showed that the woman have been submitted to quadrantectomy with lymph node dissection followed by cobalt therapy for breast cancer. Based on the pharmacological history, intake of drugs was excluded. Routine blood chemistry and instrumental tests did not show any alteration, nor did assays of the main autoantibodies, complement, circulating immunocomplexes, or tumor markers. CONCLUSIONS: Histologically the picture was compatible with the diagnosis of Eosinophilic cellulitis. Following topical corticosteroid therapy the lesion healed rapidly. It relapsed 2 months later, and was again cured with the same topical treatment. No further relapses were observed in a 1 year follow-up.- - - - - - - - - - ranking = 1keywords = dermatitis (Clic here for more details about this article) |
2/28. Transient eosinophilia by HIV infection.We describe a case of early human immunodeficiency virus infection characterized by transient eosinophilia without an elevated immunoglobulin e concentration, allergic symptoms, or atopic dermatitis. Possible mechanisms of the eosinophilia are discussed.- - - - - - - - - - ranking = 1keywords = dermatitis (Clic here for more details about this article) |
3/28. Allergic reaction to gemfibrozil manifesting as eosinophilic gastroenteritis.Eosinophilic gastroenteritis (EGE) is a rare condition of unknown etiology characterized by eosinophilic infiltration of the gastrointestinal (GI) tract. Previous associations with a drug or food allergy, allergic rhinitis, atopic dermatitis, and elevated IgE levels suggest an atopic predisposition in the pathogenesis of this disorder. Diagnostic criteria are GI symptoms, eosinophilic infiltration proven by biopsy of the GI tract, and absence of parasitic infection. We describe a case of EGE manifested as an allergy to gemfibrozil.- - - - - - - - - - ranking = 1keywords = dermatitis (Clic here for more details about this article) |
4/28. Persistent peripheral eosinophilia and cutaneous non-Hodgkin's lymphoma: a case report and review of the literature.Peripheral eosinophilia can be the presenting sign in many cutaneous diseases but is often missed as a marker of a serious undiagnosed underlying disease such as atopic dermatitis, urticaria, drug eruption, bullous pemphigoid, inflammatory bowel disease, helminthic infection, churg-strauss syndrome, rheumatoid arthritis, or lymphoma. We report a case of non-Hodgkin's lymphoma presenting as persistent eosinophilia with a diffuse nodular cutaneous eruption.- - - - - - - - - - ranking = 1keywords = dermatitis (Clic here for more details about this article) |
5/28. Acute myocarditis with transient eosinophilia and serum hyper-IgE-emia in a patient with atopic dermatitis.A 14-year-old girl with acute myocarditis, transient eosinophilia, and hyper-IgE-emia associated with atopic dermatitis is described. The patient was admitted because of severe heart failure and shock, and severe atopic dermatitis was seen. blood examinations showed moderate eosinophilia (1917/mm3) and hyper-IgE-emia (830IU/ml). The response to treatment with dopamine was excellent, and the congestive heart failure was gradually ameliorated, followed by improvement in her atopic dermatitis. In addition, rapid improvement in eosinophilia and hyper-IgE-emia was observed. Histopathological examination of the right ventricular myocardium obtained by endomyocardial biopsy showed mild interstitial fibrosis and mild infiltrations of inflammatory cells, indicating myocarditis. We speculated that the transient eosinophilia and hyper-IgE-emia in the present case indicated that an allergen induced strong allergic reactions, including type 1 allergy, and caused both acute myocarditis and deterioration of the atopic dermatitis; specifically noteworthy is that the patient's disease rapidly improved without corticosteroid treatment.- - - - - - - - - - ranking = 8keywords = dermatitis (Clic here for more details about this article) |
6/28. Wells' syndrome: a clinical and histopathologic review of seven cases.Wells' syndrome, or eosinophilic cellulitis, is characterized clinically by an acute dermatitis resembling cellulitis, which evolves into violaceous plaques that resolve spontaneously without scarring. The histopathologic features are dynamic, starting with dermal edema and infiltration of eosinophils, the development of "flame figures," and finishing with the appearance of phagocytic histiocytes. We present the clinical and histopathologic features of seven cases of eosinophilic cellulitis.- - - - - - - - - - ranking = 1keywords = dermatitis (Clic here for more details about this article) |
7/28. The hyperimmunoglobulin E syndrome.Hyperimmunoglobulin E syndrome is a primary immunodeficiency disease characterized by markedly high titers of serum immunoglobulin e (IgE), chronic eczema, recurrent staphylococcal infections, pneumatoceles, reduced neutrophil chemotaxis, and variable impaired T cell function. There are no clinical tools for diagnosis and definitive laboratory investigation. Variability of presentation makes it easy to confuse the diagnosis with that of severe atopy or other rare immunodeficiencies. We report a case of a 6-year-old boy with hyperimmunoglobulin E syndrome with recurrent methicillin-resistant staphylococcus aureus furunculosis. physical examination revealed a peculiar facial appearance, pruritic dermatitis, and furunculosis over the scalp, neck, and back. Laboratory investigation revealed mild leukocytosis with eosinophilia, a very high immunoglobulin e level, defective neutrophil chemotaxis, and impaired lymphocyte proliferation to anti-CD3/CD28 monoclonal antibodies. The boy was discharged without incident after 2 weeks of antibiotic therapy and debridement.- - - - - - - - - - ranking = 1keywords = dermatitis (Clic here for more details about this article) |
8/28. Allergic contact dermatitis and eosinophilia in association with a hemodialysis cannula.After starting daily hemodialysis (HD) therapy, 2 patients experienced pruritic, erythematous, papular eruptions at their arteriovenous fistula sites. Both patients also developed systemic eosinophilia, with eosinophil counts from 1.0 to 4.4 x 10(9) . In all other respects, the patients were well and both had a subjective improvement in their quality of life. Results of initial investigations to rule out the possibility of parasites, collagen vascular disease, and myeloproliferative disorders were negative in 1 patient. Subsequent patch testing in both patients was positive for allergic contact dermatitis secondary to the epoxy resin used in their blunt HD needles.- - - - - - - - - - ranking = 5keywords = dermatitis (Clic here for more details about this article) |
9/28. Syndrome of severe skin disease, eosinophilia, and dermatopathic lymphadenopathy in patients with HTLV-II complicating human immunodeficiency virus infection.Two intravenous drug users dually infected with human immunodeficiency virus type 1 (hiv-1) and human T-cell leukemia virus type II (HTLV-II) developed an unusual severe dermatitis characterized by progressive brawny induration, fissuring, and ulceration of the skin, with an associated CD8 cell infiltration in one patient. Both patients had persistent eosinophilia. Lymph node biopsy revealed dermatopathic lymphadenopathy, an unusual pathologic finding in hiv-1 infection but one seen in association with mycosis fungoides and other skin disorders. Two new isolates of HTLV-II virus were established from these patients and were identified as HTLV-II by Southern blotting. This type of skin disease and lymph node pathology has not been found in other intravenous drug users who have been infected with hiv-1 alone or in patients in other risk groups for hiv-1 infection. HTLV-II may play a role in this unique new disease pattern in patients infected with hiv-1.- - - - - - - - - - ranking = 1keywords = dermatitis (Clic here for more details about this article) |
10/28. Variant of hyper-IgE syndrome: the differentiation from atopic dermatitis is important because of treatment and prognosis.The hyper-IgE syndrome is characterized clinically by recurrent staphylococcal abscesses of the skin, lungs and other sites from infancy. Affected patients also have a pruritic dermatitis that differs in character and distribution from lesions of atopic dermatitis. Most lack other signs of atopic disease, develop persistent pneumatoceles and have osteopenia. Laboratory abnormalities include the consistent presence of marked hyperimmunoglobulinemia E and eosinophilia of blood, sputum and tissues. They may have other inconsistent abnormalities of humoral and cellular immune responses and sometimes of phagocytic cell chemotactic responsiveness. Other clinical problems reported in such patients have included lymphomas, cryptococcal meningitis and cutaneous fungal disease. An 18-year-old male patient with a variant of the hyper-IgE syndrome, which he had acquired after a measles attack at the age of 5 years, suffered from recurrent ulcerative dermatitis and lymph node abscesses. Immunological investigation revealed an excessively elevated total serum IgE level (46,850 IU/ml), the presence of specific IgE to staphylococci, and quantitative and functional deficiency of IgG2. skin and serological (radioallergosorbent) tests to inhalant and nutritive allergens were negative. Differentiation from atopic dermatitis should be made, because a long-term antistaphylococcal regime not only improves skin lesions but hinders the occurrence of lung abscesses and pneumatoceles.- - - - - - - - - - ranking = 8keywords = dermatitis (Clic here for more details about this article) |
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