1/6. A 30 year history of panniculitis.The differential diagnosis of panniculitis may be challenging due to the uniform clinical presentation of different panniculitis subsets. We describe a 45-year-old woman with a 30 year history of panniculitis, who had repeatedly failed to fulfill diagnostic criteria for various panniculitis subsets. Finally, erythema induratum was diagnosed and she was successfully treated with antituberculous chemotherapy. The wide spectrum of histological alterations of chronic erythema induratum as well as the sensitivity of polymerase chain reaction for mycobacterium tuberculosis in erythema induratum lesions is discussed.- - - - - - - - - - ranking = 1keywords = panniculitis (Clic here for more details about this article) |
2/6. Recurrent panniculitis in a man with asthma receiving treatment with leukotriene-modifying agents.Leukotriene-modifying drugs are novel agents introduced recently to treat asthma. Both 5-lipoxygenase inhibitors, such as zileuton, and leukotriene receptor antagonists, such as zafirlukast and montelukast, have proved effective in the treatment of asthma. To our knowledge, there have been no detailed reports regarding dermatologic manifestations of this class of drugs. This article describes an unusual case of erythema nodosum in a 46-year-old asthmatic man who received 2 different leukotriene modifiers.- - - - - - - - - - ranking = 0.5keywords = panniculitis (Clic here for more details about this article) |
3/6. Mycobacteria other than mycobacterium tuberculosis are not present in erythema induratum/nodular vasculitis: a case series and literature review of the clinical and histologic findings.erythema induratum (EI)/nodular vasculitis (NV) is characterized by recurrent crops of tender oedematous nodules on the lower legs. A lobular panniculitis with granulomatous inflammation, vasculitis, focal necrosis and septal fibrosis is present. mycobacterium tuberculosis dna has been detected in some lesions by means of polymerase chain reaction (PCR). Ten cases of EI/NV were found. H&E slides were reviewed. PCR assays for M. tuberculosis and mycobacteria other than M. tuberculosis (MOTT) were performed. PCR did not reveal M. tuberculosis (0%) or MOTT (0%) dna, with positive controls, indicating the reliability of the assays. Among the MOTT, cutaneous infections are most commonly caused by M. marinum. Subcutaneous tuberculoid granulomas may be seen with M. kansasii, M. marinum, M. scrofulaceum and M. avium complex. M. gordonae, M. szulgai and M. malmoense rarely cause cutaneous infections. M. simiae, M. gastri and M. asiaticum are probably not cutaneous pathogens. M. tuberculosis and MOTT dna was not found in EI/NV. EI/NV has diverse aetiologies with varying pathogeneses leading to similar histologic changes. The cases analysed may not have had an infectious aetiology. However, in EI/NV, performance of PCR for MOTT as well as M. tuberculosis complex may still be beneficial, particularly in cases from immunocompromised hosts.- - - - - - - - - - ranking = 0.125keywords = panniculitis (Clic here for more details about this article) |
4/6. erythema induratum of Bazin in an infant after Bacille Calmette-Guerin vaccination.We report the first case of erythema induratum of Bazin (EIB) after Bacille Calmette-Guerin (BCG) vaccination in an infant. The patient developed recurrent multiple erythematous and subcutaneous nodules on his legs 2 months after a BCG vaccination. He had no other symptoms or family history of tuberculosis (TB). Histopathological findings revealed a granulomatous lobular panniculitis. EIB often appears as a chronic, nodular eruptions that frequently occur on the lower legs of females with tuberculin hypersensitivity. To date, only a few cases of infants with EIB have been reported. There have been no clinical reports of EIB after BCG vaccination. Our case suggests that mycobacterium bovis in the BCG vaccination may have caused EIB.- - - - - - - - - - ranking = 0.125keywords = panniculitis (Clic here for more details about this article) |
5/6. erythema induratum - a hypersensitivity reaction to mycobacterium tuberculosis.erythema induratum (also known as Bazin disease, tuberculosum, tuberculosis cutis indurativa and nodose tuberculid) is a rare condition that produces painful, firm, and sometimes ulcerated nodules on the lower legs. Distinctive and diagnostic histopathology comprises a septolobular panniculitis, necrosis, granulomatous inflammation and vasculitis.- - - - - - - - - - ranking = 0.125keywords = panniculitis (Clic here for more details about this article) |
6/6. Mycobacterial subcutaneous arteritis.The authors report three patients with subcutaneous erythematous nodules in different phases of development, unspecific systemic symptoms, positive PPD test, and normal chest x-rays. The histopathological study of the older nodules showed a granulomatous arteritis with a few acid-fast bacilli in the vascular wall. The nodules at an early phase showed an unspecific panniculitis with some acid-fast bacilli in apparently normal cutaneous vessels. These findings suggest that the mycobacterium has a vascular tropism and may cause a primary granulomatous arteritis.- - - - - - - - - - ranking = 0.125keywords = panniculitis (Clic here for more details about this article) |