1/7. parvovirus-B19 infection preceding acute myeloid leukemia with orbital granulocytic sarcoma.We report here an unusual presentation of acute nonlymphoblastic leukemia with ocular granulocytic sarcoma who was firstly diagnosed iron deficiency anemia and acute parvovirus infection induced erythroid hypoplasia. To our knowledge this is the first paper of acute myeloblastic leukemia (AML) with granulocytic sarcoma, preceded by acute parvovirus B19 infection.- - - - - - - - - - ranking = 1keywords = leukemia (Clic here for more details about this article) |
2/7. Bone marrow necrosis and human parvovirus associated infection preceding an Ph1 acute lymphoblastic leukemia.A case of bone marrow necrosis associated with a serologically documented recent parvovirus B 19 infection which preceded the development of PH1 acute lymphoblastic leukemia is reported. No conclusions can be drawn on the basis of a single case but the question of the role of human parvovirus B19 in the pathogenesis of bone marrow necrosis is discussed. It is suggested that the virus may act as a co-factor for the induction of bone marrow necrosis, in some cases.- - - - - - - - - - ranking = 0.83333333333333keywords = leukemia (Clic here for more details about this article) |
3/7. Acute parvovirus B19 infection mimicking myelodysplastic syndrome of the bone marrow.A 36-year-old, previously healthy woman was referred to our institution with pancytopenia and splenomegaly for suspected acute leukemia. Bone marrow aspiration showed marked dysplastic changes, excess of blasts, and only spurious red blood cell precursors. Action was taken to prepare allogeneic bone marrow transplantation from an HLA identical sibling for myelodysplastic syndrome. Repeat cytological examination of the bone marrow revealed striking hyperplasia of the red cell line with presence of abnormal giant proerythroblasts. Acute parvovirus B19 infection was suspected and confirmed by detection of anti-B19 IgM and B19 dna. The underlying disease for this transient aplastic crisis was a formerly unknown hereditary spherocytosis.- - - - - - - - - - ranking = 0.16666666666667keywords = leukemia (Clic here for more details about this article) |
4/7. Acquired pure red cell aplasia: a study of six cases.Persistent infection by parvovirus B19 associated with pure red cell aplasia (PRCA) has been documented in immunocompromised patients. Bone marrow failure is associated with conditions in which immune surveillance is impaired, and in these instances occult parvovirus infection may be suspected. In this study we have assessed by serological and molecular methods whether parvovirus B19 infection may be a more frequent cause of PRCA than hitherto suspected and whether it may be present in the absence of a typical bone marrow picture. Six patients with PRCA--two with isolated PRCA and no apparent underlying disease, two with a lymphoproliferative disease, one with thymoma, and one with chronic myelomonocytic leukemia--have been studied. Four of the six patients had overt PCRA and were clearly immunocompromised. parvovirus B19 was not detected in any of the six patients by PCR analysis and serology investigating the presence of IgM or IgG antibodies. Although parvovirus B19 infection needs to be ruled out in PRCA it represents only one, and probably not the most frequent, etiological factor of PRCA.- - - - - - - - - - ranking = 0.16666666666667keywords = leukemia (Clic here for more details about this article) |
5/7. Persistent erythema infectiosum-like rash as a prodrome of acute lymphocytic leukemia.A 7-year-old boy had erythema infectiosum with typical manifestations. Over more than 40 days, these lesions showed no sign of regression, and chronic anemia became progressively more severe. Electron microscopic examination performed 20 days after onset showed abnormal Sezary-like lymphocytes. Bone marrow biopsy, which was performed to evaluate the anemia, was consistent with acute lymphocytic leukemia. Persistent parvovirus B19 infection may be connected with immunosuppression. Therefore, early electron microscopic study and bone marrow biopsy may be helpful for early diagnosis of hematologic malignancies.- - - - - - - - - - ranking = 0.83333333333333keywords = leukemia (Clic here for more details about this article) |
6/7. parvovirus B19 as a cause of chronic anemia in rhabdomyosarcoma.BACKGROUND. Several reports have been published of anemia due to infection by parvovirus in patients receiving chemotherapy for leukemia. However, parvovirus B19 has not been previously identified as a cause of chronic anemia in children with solid tumors. methods. A child with rhabdomyosarcoma developed chronic anemia, with need for regular blood transfusions during chemotherapy. An infectious etiology was sought. RESULTS. B19 viremia and an absent antibody response was present during the period of chronic anemia during chemotherapy. After completion of chemotherapy, the viremia cleared, IgM and IgG antibody to B19 virus were detected, and the anemia resolved. CONCLUSIONS. parvovirus must be considered as a cause of anemia in patients undergoing chemotherapy for solid tumors as well as leukemia.- - - - - - - - - - ranking = 0.33333333333333keywords = leukemia (Clic here for more details about this article) |
7/7. Transient aplastic crisis in a leukemic child caused by parvovirus B19 infection.Acute parvovirus B19 infection was confirmed in an 8-year-old girl with acute lymphoblastic leukemia on maintenance therapy by electron microscopy, dna, and serological techniques. Clinical manifestations were typical of severe anemia, fever, leukopenia, and thrombocytopenia. Increased levels of serum erythropoietin were detected in the course of the infection. The patient's recovery was supported by corticosteroids, red blood cell transfusions, G-CSF, and commercial immunoglobulin preparations.- - - - - - - - - - ranking = 0.16666666666667keywords = leukemia (Clic here for more details about this article) |