1/49. acute generalized exanthematous pustulosis induced by chromium picolinate.A case of acute generalized exanthematous pustulosis (AGEP) due to chromium picolinate is described. This supplemental form of chromium has received a great deal of interest recently because of its possible beneficial effects on both muscle strength and body composition. There have been no previous reports to our knowledge of adverse cutaneous reactions to this agent. Various aspects of AGEP are reviewed.- - - - - - - - - - ranking = 1keywords = exanthematous pustulosis, exanthematous, pustulosis (Clic here for more details about this article) |
2/49. acute generalized exanthematous pustulosis associated with oral terbinafine.A case history of acute generalized exanthematous pustulosis (AGEP) following oral terbinafine is reported. A 64-year-old woman presented with a rapidly spreading micropustular eruption 3 days after completing a 28-day course of oral terbinafine. There was a positive family history of psoriasis but no personal history. The clinical presentation and histopathology were consistent with AGEP. There was nearly complete resolution of the pustular eruption within 3.5 weeks following cessation of oral terbinafine and treatment with topical and systemic corticosteroids. The patient has remained free of any recurrence 18 months later. A summary of drugs known to be associated with AGEP is presented. Prompt recognition of AGEP is stressed in order to avoid confusion with acute generalized pustular psoriasis or a systemic infection. The most important aspect of management is the immediate withdrawal of the suspect drug.- - - - - - - - - - ranking = 1keywords = exanthematous pustulosis, exanthematous, pustulosis (Clic here for more details about this article) |
3/49. clindamycin-induced acute generalized exanthematous pustulosis.acute generalized exanthematous pustulosis is a rare but distinctive entity that may be associated with various etiologies. Drug exposure is the most common cause. We present the first report of acute generalized exanthematous pustulosis induced by the drug clindamycin.- - - - - - - - - - ranking = 1.2keywords = exanthematous pustulosis, exanthematous, pustulosis (Clic here for more details about this article) |
4/49. Localized pustulosis induced by betalactams.Localized forms of pustular drug eruptions related to antibiotics are uncommon and their mechanism is still unknown. We describe herein a patient who developed numerous pin-head pustules without erythema in the peribuccal area after ingestion of ceftibuten and amoxicillin. The relationship with these drugs was confirmed by single-blind oral challenges. The following tests were performed: prick and intradermal tests with benzylpenicilloyl polylysine, minor determinant mixture, benzylpenicillin and amoxicillin; patch tests were also carried out with benzylpenicillin, amoxicillin, cloxacillin, cefuroxime, ceftriaxone, cefazolin, ceftibuten and cefaclor. All cutaneous tests were negative. Controlled single-blind challenge tests were performed with amoxicillin, cefadroxil, ceftibuten, cefuroxime, cefaclor, erythromycin and ciprofloxacin. All betalactam antibiotics tested gave a positive reaction, with good tolerance of other antibiotics; this would appear to indicate a specific mechanism of hypersensitivity and not an unspecific reaction to wide spectrum antibiotics.- - - - - - - - - - ranking = 0.0095378191657807keywords = pustulosis (Clic here for more details about this article) |
5/49. acute generalized exanthematous pustulosis (AGEP), an uncommon condition in children: case report and review of the literature.acute generalized exanthematous pustulosis (AGEP) is characterized by acute onset of a widespread pustular eruption in association with fever. It is usually seen as a medication reaction. We describe a 17-month-old boy with AGEP secondary to exposure to amoxicillin. This is an uncommon condition in children.- - - - - - - - - - ranking = 1keywords = exanthematous pustulosis, exanthematous, pustulosis (Clic here for more details about this article) |
6/49. Acute generalized exanthematic pustulosis (AGEP) in a patient treated with furosemide.BACKGROUND: Although they appear more rarely than electrolyte disturbances, cutaneous reactions are important adverse effects of furosemide. This is particularly true for bullous skin eruptions, because they may be life-threatening. CASE REPORT: We describe a patient who developed acute generalized exanthematic pustulosis (AGEP) during treatment with furosemide. Because the patient had developed similar skin eruptions during treatment with furosemide years before, furosemide was considered the most likely cause of this reaction. The short period of time between exposure to furosemide and the appearance of the skin reaction, as well as a positive lymphocyte transformation test, suggest an immunological mechanism of the skin disease. CONCLUSION: AGEP is a possible cutaneous side effect of furosemide.- - - - - - - - - - ranking = 0.011922273957226keywords = pustulosis (Clic here for more details about this article) |
7/49. Acute exanthematous pustular drug eruption induced by mexiletine.A 56-year-old man developed infiltrated erythemas on the trunk, extremities, and face with marked facial edema, one month after taking mexiletine hydrochloride for his arrhythmia. A number of pustules were also noted on the surface of erythemas on his chest and face. Laboratory examination showed liver dysfunction and hypereosinophilia. The culture from pustules was sterile. Histological examination of the biopsied skin from a pustular lesion revealed a subcorneal abscess, and perivascular infiltration of lymphocytes, mononuclear cells and eosinophils in the upper dermis. The skin lesions and facial edema as well were improved within three weeks by withdrawal of mexiletine hydrochloride. patch tests with 10% and 20% mexiletine hydrochloride in petrolatum showed positive reaction, however, pustules were not provoked on the tested site. We conclude that pustules, infiltrated erythema and facial edema were the signs of acute exanthematous pustular drug eruption induced by mexiletine hydrochloride.- - - - - - - - - - ranking = 0.27604824944569keywords = exanthematous (Clic here for more details about this article) |
8/49. acute generalized exanthematous pustulosis associated with STI571 in a patient with chronic myeloid leukemia.The tyrosine kinase inhibitor STI571 is a novel promising class of anticancer drugs. We report a case of cutaneous adverse reactions to STI571 in a young woman with blast crisis of chronic myeloid leukemia. She had first typical acute generalized exanthematous pustulosis mimicking mercury rash and then urticarial eruption. We suggest that cell pathways mediated by some tyrosine kinases might be involved in the pathogenesis of these skin eruptions.- - - - - - - - - - ranking = 1keywords = exanthematous pustulosis, exanthematous, pustulosis (Clic here for more details about this article) |
9/49. acute generalized exanthematous pustulosis induced by ingestion of bamifylline.We report a case of acute generalized exanthematous pustulosis (AGEP) in a 64-year-old woman, associated with the use of bamifylline. To the best of our knowledge there have been no previous reports of AGEP induced by the ingestion of bamifylline in the medical literature. We, therefore, add this drug to the list of causes for AGEP.- - - - - - - - - - ranking = 1keywords = exanthematous pustulosis, exanthematous, pustulosis (Clic here for more details about this article) |
10/49. A case of recurrent acute generalized exanthematous pustulosis due to beta-lactam antibiotics: a case report.A case of acute generalized exanthematous pustulosis (AGEP) is presented. The case is notable for the recurrent episodes of AGEP, caused by three beta-lactam antibiotics (piperacillin, ceftazidime, and meropenem) in septicemic patient. The case represents the first report of the reaction developing in response to these three antibiotics. The report is also notable for the spontaneous resolution of the rash in all the three episodes.- - - - - - - - - - ranking = 1keywords = exanthematous pustulosis, exanthematous, pustulosis (Clic here for more details about this article) |
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