Cases reported "Eye Neoplasms"

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1/67. Malignant melanoma of the choroid in neurofibromatosis.

    A 60-year-old white woman with generalized neurofibromatosis and multiple melanocytic hamartomas of the iris developed an unusual choroidal mass, with secondary sensory retinal separation in the left eye. Ophthalmoscopically the tumor had a peculiar donut configuration that was caused by a large focus of central necrosis within a spindle B melanoma.
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ranking = 1
keywords = melanocytic
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2/67. listeria monocytogenes endophthalmitis with a black hypopyon.

    A 68-year-old woman had a marked decrease in visual acuity, increased intraocular pressure, and acute iridocyclitis. She developed a pigmented hypopyon simulating an occult intraocular melanoma. Two anterior chamber paracenteses showed growth of listeria monocytogenes. The patient received systemic intravenous penicillin, topical fortified gentamicin sulfate drops, and intraocular injections of cephaloridine. On discharge from the hospital after a two-week stay, visual acuity had improved and intraocular pressure had decreased.
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ranking = 0.82709760200966
keywords = pigmented
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3/67. blindness as a consequence of a paraneoplastic syndrome in a woman with clear cell carcinoma of the ovary.

    BACKGROUND: paraneoplastic syndromes are rare conditions associated with cancer that result in serious disease states at unique sites. In 1982, a report of bilateral diffuse uveal melanocytic proliferation associated with nonocular cancers which resulted in blindness was reported. We present a case of a woman with recurrent ovarian cancer who developed this paraneoplastic syndrome. CASE: A 55-year-old woman had been diagnosed in 1990 with an ocular melanoma of her right eye and in 1994 with clear cell carcinoma of the ovary. With recurrence of ovarian cancer, new eye lesions were identified in both eyes. After enulcleation of her right eye, an ocular melanoma and diffuse bilateral melanocytic proliferation (BDUMP) were found. The sight in her left eye continued to deteriorate as other signs of BDUMP occurred in the eye. Within 1 month of diagnosis, the patient was blind. She subsequently succumbed to progression of ovarian cancer. CONCLUSION: Recurrent ovarian cancer is usually an intraabdominal disease that results in gastrointestinal dysfunction. This case illustrates a rare paraneoplastic syndrome associated with ovarian cancer that mimics metastatic disease to the eye, but has a different pathophysiology.
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ranking = 2
keywords = melanocytic
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4/67. Posterior scleral choristoma in the organoid nevus syndrome (linear nevus sebaceus of Jadassohn).

    PURPOSE: To highlight the association of posterior osseous and/or cartilaginous ocular choristomas with epibulbar choristomas and the nevus sebaceus of Jadassohn. DESIGN: Small case series. PARTICIPANTS: Four patients with the organoid nevus syndrome. methods: Clinical and histopathologic studies in four patients with epibulbar lesions and nevus sebaceus of Jadassohn. MAIN OUTCOME MEASURES: Ophthalmoscopic findings of peripapillary lesions. Computed tomographic and ultrasonographic characteristic of posterior scleral lesions. Ocular histopathologic findings in one globe from one of the study subjects. RESULTS: Three patients had the triad of posterior osseous/cartilaginous ocular choristomas, anterior epibulbar choristomas, and nevus sebaceus of Jadassohn and one patient had anterior epibulbar choristomas and posterior osseous/cartilaginous ocular choristomas. ultrasonography and computed tomography were valuable in detecting scleral ossification or epibulbar cartilage or both. The ophthalmoscopic findings were similar to those of a choroidal osteoma. CONCLUSIONS: The presence of posterior osseous/cartilaginous ocular choristomas in a patient with epilepsy or epibulbar lesions or both suggests the diagnosis of nevus sebaceus of Jadassohn. Osseous/cartilaginous ocular choristomas should be suspected in patients with nevus sebaceus of Jadassohn and peripapillary hypopigmented fundus lesions.
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ranking = 0.82709760200966
keywords = pigmented
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5/67. adenoma of the pigmented ciliary epithelium: ultrastructural and immunohistochemical findings.

    We report the clinical and histological findings in a tumor of the pigmented ciliary epithelium. The tumor was detected because it had caused a unilateral cataract, and it was removed by local resection because a malignant melanoma could not be excluded. The diagnosis was established by light microscopy, and additional immunohistochemical and detailed ultrastructural studies were performed. The so-called foam cells which are considered typical of these adenomas appear to be mostly light microscopic artifacts and had no ultrastructural equivalent in the sections examined from our tumor. Our results also strongly support the hypothesis that no true glandular elements are formed and that, apart from the neoplastic tissue architecture, most of the pathological findings are related to melanosomes.
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ranking = 4.1354880100483
keywords = pigmented
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6/67. Compound nevus of the cornea simulating a foreign body.

    PURPOSE: To report a corneal nevus, without conjunctival involvement, that clinically simulated a metallic foreign body. methods: Case report with clinicopathologic correlation. RESULTS: A 22-year-old man developed a superficial pigmented lesion of his left cornea. It was suspected to be a chronically retained foreign body, but a melanocytic neoplasm could not be excluded. The lesion was removed by lamellar keratectomy and proved histopathologically to be a compound nevus of the cornea, without conjunctival involvement. CONCLUSIONS: Melanocytic nevus can rarely occur in the cornea. Involvement of the cornea by a melanocytic lesion does not necessarily imply a malignant melanoma.
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ranking = 2.8270976020097
keywords = melanocytic, pigmented
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7/67. Clinicopathological report Periocular tumour of the follicular infundibulum.

    Tumour of the follicular infundibulum (TFI) is an uncommon, benign lesion of the skin adnexae. Four cases are reported of periocular TFI. In all cases a clinical diagnosis of basal cell carcinoma was made before surgery; however, histopatholog ca examination revealed TFI. This is an epithelial tumour showing differentiation along the lines of the follicular infundibulum. Characteristic features are a shelf-like proliferat on of pale epithelia cells in the upper dermis, attachment to the epidermis and the upper portions of the pilosebaceous units, a dense border of elastic fibres, and palisading of the peripheral cell layer of the tumour plate. This benign tumour has not, to the authors' knowledge, been reported in the ophthalmic literature. It has a non-specific appearance and may be clinically misdiagnosed as naevus sebaceous, xanthoma, seborrhoeic keratosis, or basal cell carcinoma.
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ranking = 6.640991205261
keywords = naevus
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8/67. A case of glaucoma associated with sturge-weber syndrome and nevus of ota.

    The sturge-weber syndrome consists of a unilateral port-wine hemangioma of the skin along the trigeminal distribution and is accompanied by an ipsilateral leptomeningeal angioma. glaucoma is present in approximately half of the cases. The nevus of ota is a melanocytic pigmentary disorder, most commonly involving the area innervated by the trigeminal nerve. Elevated intraocular pressure, with or without glaucomatous damage, is observed in 10% of the cases. We report the first case of glaucoma associated with sturge-weber syndrome and nevus of ota in korea.
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ranking = 1
keywords = melanocytic
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9/67. A unique case of primary corneal melanoma.

    PURPOSE: To report a unique case of primary corneal melanoma. methods: A 59-year-old white woman underwent keratectomy to remove a pigmented rapidly enlarging growth on the corner of her left eye. The specimen was submitted for histopathologic examination. RESULTS: Ophthalmic examination disclosed no association with limbal or conjunctival melanocytic abnormalities. Histopathologic studies demonstrated nodular malignant melanoma. CONCLUSION: Possible development of primary corneal melanoma should be considered in diagnosing all cases with a past history of corneal melanin pigmentation.
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ranking = 1.8270976020097
keywords = melanocytic, pigmented
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10/67. Metastatic cutaneous melanoma to the vitreous cavity masquerading as intermediate uveitis.

    PURPOSE: To report a patient with metastatic cutaneous melanoma (MCM) presenting as intermediate uveitis. methods: We examined a 49-year-old man with malignant cutaneous melanoma and central nervous system (CNS) metastasis who was initially treated for bilateral intermediate uveitis. Biomicroscopic examination disclosed a normal anterior segment and vitreous organization with red blood cells (RBC) and some non-pigmented cells in both eyes. Funduscopy disclosed a retinal metastasis in the right eye, but vitreous organization precluded visualization of the retina in the left eye. RESULTS: The first diagnostic vitrectomy was negative for malignant cells in the left eye. However, progressive worsening of the condition persuaded us to repeat vitrectomy in the left eye and to do it in the right eye too. Vitreous samples were positive for malignant melanoma cells in both eyes. CONCLUSIONS: Metastatic cutaneous melanoma to the vitreous cavity is exceedingly rare and may masquerade as intermediate uveitis. It should be considered in the differential diagnosis of unusual uveitis and masquerade syndromes.
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ranking = 0.82709760200966
keywords = pigmented
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