1/19. Giant cutaneous horn associated with verruca vulgaris.Cutaneous horn (cornu cutaneum) is the clinical description of a hyperproliferation of compact keratin in response to a wide array of underlying benign and malignant pathologic changes. We report a patient with a giant cutaneous horn associated with a verruca vulgaris. The possible causes of cutaneous horns are reviewed.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
2/19. Is demodex really non-pathogenic?Although usually considered a non-pathogenic parasite in parasitological textbooks, Demodex folliculorum has been implicated as a causative agent for some dermatological conditions, such as rosacea-like eruptions and some types of blepharitis. Several anecdotal reports have demonstrated unequivocal tissue damage directly related to the presence of the parasite. However, this seems to be exceedingly rare, in contrast with the marked prevalence of this infestation. We have had the opportunity to observe one of such cases. A 38-year-old woman presented with rosacea-like papular lesions in her right cheek. Histopathological examination revealed granulomatous dermal inflammation with a well-preserved mite phagocytized by a multinucleated giant cell. This finding may be taken as an evidence for the pathogenicity of the parasite, inasmuch as it does not explain how such a common parasite is able to produce such a rare disease.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
3/19. chediak-higashi syndrome.A case of chediak-higashi syndrome is reported in a four-year-old boy who presented with recurrent chest infection, partial albinism, hyperpigmentation of the extremities and presence of giant granules in leucocytes and melanocytes in the skin. Parental consanguinity was present. Though uncommon, hyperpigmentation of sun exposed areas may be the initial symptom in chediak-higashi syndrome.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
4/19. Giant recurrent pyogenic granuloma on the face with satellitosis responsive to systemic steroids.Pyogenic granuloma is a common benign skin tumour. However, giant recurrent pyogenic granuloma with satellitosis is relatively rare. We present a 52-year-old man who had recurrent gigantic pyogenic granuloma with satellitosis responsive to systemic steroids. Our case of recurrent pyogenic granuloma is interesting because of its clinical presentation, recurrence following surgical excision and its steroid responsiveness. Systemic steroids may be effective in treating recurrent giant pyogenic granulomas during their high-proliferation phase.- - - - - - - - - - ranking = 2keywords = giant (Clic here for more details about this article) |
5/19. "Giant" senile sebaceous hyperplasia.Although the usual size of senile sebaceous hyperplasia is 2 to 3 mm in diameter, we report one "giant" nodular case on the face. The patient is a 75-year-old Japanese man with a dome-shaped, skin-colored nodule on his right cheek. The lesion was 10 mm in diameter and had multiple small umbilications on its surface. He also had several small, yellow-colored, asymptomatic papules with central umbilication on his cheeks. Histologically, the giant nodule and the papule on the right cheek showed the same architectural pattern, a sharply demarcated hyperplasia of grouped mature sebaceous glands with a sebaceous converging duct, whose opening to the surface epithelium corresponded to the clinical umbilication. The reason for the giant growth of this senile sebaceous hyperplasia in our case is obscure; the patient had not been stressed by inductive agents or factors such as systemic corticosteroid and hemodialysis except for electrocoagulation on the lesion. In spite of the extraordinarily large size of the nodule, the conservative proliferating pattern seemed to show the benign hyperplastic character of senile sebaceous hyperplasia.- - - - - - - - - - ranking = 3keywords = giant (Clic here for more details about this article) |
6/19. keratoacanthoma centrifugum marginatum accompanied by extensive granulomatous foreign body reaction.We describe a 58-year-old woman with a 4-year history of papular lesions with a partly verruciform appearance on the eyelids and the adjacent areas of the nose. The lesions progressed slowly but constantly into the surrounding areas with central scarring. Histopathology showed epidermal endophytic proliferations under a pronounced hyperparakeratosis. In the adjacent dermis a lymphohistiocytic infiltrate with giant cells of the foreign-body-reaction type was seen in close contact to extracellular keratin deposits. Although some cytopathological signs typical for viropathic effects were observed, no human papilloma virus-dna was detected within the lesions by polymerase chain reaction. According to the histological picture and the clinical course we diagnosed a keratoacanthoma centrifugum marginatum. We present this case because of the strong granulomatous foreign body reaction which might complicate the diagnosis and has not been described for this keratoacanthoma variant so far.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
7/19. Self-healing juvenile cutaneous mucinosis: cases highlighting subcutaneous/fascial involvement.BACKGROUND: Self-healing juvenile cutaneous mucinosis is a rare disease affecting young people characterized by transient cutaneous lesions and sometimes mild inflammatory symptoms. The deep dermal and subcutaneous features of this disorder have not yet been well described. OBJECTIVE: The purpose of our study was to present 3 cases of self-healing juvenile cutaneous mucinosis in which the histopathologic features caused diagnostic confusion between this disorder and proliferative fasciitis. methods: The study includes clinical and histologic findings of 3 patients, complemented by a literature review. RESULTS: The histologic descriptions of nodular lesions in self-healing juvenile cutaneous mucinosis reveal features of proliferative fasciitis, including a myxoid stroma and gangliocyte-like giant cells. LIMITATIONS: Self-healing juvenile cutaneous mucinosis is a rare condition and has not been frequently reported in medical literature. Our findings are based on the pathologic features of 3 patients. CONCLUSIONS: Our findings further elucidate the histologic features of self-healing juvenile cutaneous mucinosis and expand the differential diagnosis for entities in which gangliocyte-like giant cells are noted.- - - - - - - - - - ranking = 2keywords = giant (Clic here for more details about this article) |
8/19. Lupus miliaris disseminatus faciei--report of a case in an elderly woman.A 71-year-old Japanese woman developed red-brown to yellow papules symmetrically on the eyelids and cheeks. The histopathology of a papule showed caseation necrosis surrounded by epitheloid cells intermingled with giant cells in the dermis. The patient was thus diagnosed as lupus miliaris disseminatus faciei (LMDF). To the best of our knowledge, no LMDF patients of such an age have been described previously.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
9/19. Granulomatous tissue reaction following cosmetic eyebrow tattooing.We report a case of epithelioid granuloma which occurred at the site of a previous cosmetic eyebrow tattooing. A biopsy specimen showed the organized appearance of epithelioid cell granulomas containing little pigment as well as occasional giant cells, mainly of Langhans' type, thus showing the characteristic features of granulomatous hypersensitivity. With the use of energy dispersive X-ray microanalysis and inductively coupled plasma spectrometry, the presence of copper, iron, cobalt, and chromium was demonstrated.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
10/19. Compositae dermatitis in childhood.Compositae dermatitis occurred in a 9-year-old boy with a strong personal and family history of atopy. Positive patch test reactions were 2 for dandelion (taraxacum officinale), false ragweed (ambrosia acanthicarpa), giant ragweed (ambrosia trifida), short ragweed (ambrosia artemisifolia), sagebrush (artemisia tridentata), wild feverfew (Parthenium hysterophorus), yarrow (achillea millifolium), and tansy (Tanacetum vulgare) and 1 for dahlia species and English ivy (hedera helix). patch tests were negative for another 30 plants, including cocklebur (xanthium strumarium), dog fennel (anthemis cotula, fleabane (erigeron strigosus), sneezeweed (Helenium autumnale), and feverfew (tanacetum parthenium). The eruption resembled atopic dermatitis morphologically but was prominent on the palms and face and dramatically spared the area of the boy's feet covered by his shoes. The condition has always been seasonal, worsening in summer, especially July, and it clears on avoidance of contact. This case is believed to represent a contact dermatitis to oleoresins of Compositae plants; inhalants as a cause of systemic aggravation are not likely to be important in this patient.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
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