1/31. Hereditary perioral pigmented follicular atrophoderma associated with milia and epidermoid cysts.Eight members of a single family all presented the characteristic changes of facial, especially perioral, pigmented follicular atrophoderma, with numerous milia and epidermoid cysts. For this condition. diagnosis at a glance may be possible because of the perioral cutaneous manifestations. Histopathological examination of follicular atrophoderma revealed proliferation of basaloid cells continuous with the epidermis and coarse collagen fibres, with a decreased density of elastic fibres around the basaloid cells. Two of the eight individuals also showed generalized hypohidrosis. The eight affected persons were the proband, her son, mother, uncle, two younger sisters, cousin and nephew: an autosomal dominant mode of transmission was suggested from this family tree. The patients' symptoms resembled those of Bazex-Dupre-Christol syndrome, except for the different distribution of the follicular atrophoderma and the absence of basal cell carcinoma and hypotrichosis. This disease may be an entirely new syndrome characterized by perioral pigmented follicular atrophoderma associated with milia and epidermoid cysts.- - - - - - - - - - ranking = 1keywords = perioral (Clic here for more details about this article) |
2/31. Malignant acanthosis nigricans: potential role of chemotherapy.acanthosis nigricans is an uncommon skin condition characterized by hyperkeratosis and skin hyperpigmentation. Most causes are benign, but it may also be associated with gastrointestinal and other malignancies. When associated with malignant disease, the skin pathology may be more severe and treatment often unsuccessful. We describe a 66-year-old man with acanthosis nigricans associated with carcinoma of the stomach, with distressing generalized cutaneous, perioral and perineal disease, whose skin condition resolved completely with combination chemotherapy. In patients with malignant acanthosis, chemotherapy may relieve many of the distressing cutaneous symptoms. A close liaison between gastroenterologists, dermatologists and oncologists is required.- - - - - - - - - - ranking = 0.14285714285714keywords = perioral (Clic here for more details about this article) |
3/31. Facial and perioral molluscum contagiosum as a manifestation of hiv infection.molluscum contagiosum (MC) is a self-limiting viral disease of the skin and the mucous membranes. Facial and perioral MC is seen with increasing frequency in human immunodeficiency (hiv) infection, particularly in hiv infected homosexual men. The purpose of this study was to describe clinical observations of facial and perioral MC in hiv infected patients. One hundred and eighty hiv-positive individuals (160 males and 20 females) were examined over a period of five years. Fifty-eight were homosexual men and 19 were bisexual men. Fifty-one of 180 patients at the time of the first examination had CD 4 count < 200 cells/mm3 and another 63 presented loss of CD 4 cells in this level, during this period. Three hiv infected patients (two homosexual and one bisexual) were affected with facial and perioral MC. At the time of MC diagnosis the CD 4 count was less than 200 cells/mm3 for all three patients. One patient died nine months after MC diagnosis and the other two are still alive. It is remarkable that in this study no clinical lesions were observed on other sites of the skin.- - - - - - - - - - ranking = 1keywords = perioral (Clic here for more details about this article) |
4/31. Partial unilateral lentiginosis with ocular involvement.Partial unilateral lentiginosis (PUL) is an unusual pigmentary disorder characterized by numerous lentigines grouped within an area of normal skin; the pigmented macules are often in a segmental distribution with a sharp demarcation at the midline. We report the first case of ocular involvement in a patient with this diagnosis. The patient, a 30-year-old Peruvian woman, had multiple brown macules on the left upper face in primarily a V1 and V2 distribution with a sharp demarcation at the midline of the forehead. The lesions first appeared near the hairline when she was 5 years of age, and then began to extend onto the face. She also had a discrete area of brown pigmentation on the left lateral bulbar conjunctiva. Because the patient had been previously diagnosed by several dermatologists as having either a speckled lentiginous nevus or a nevus of ota, we draw attention to the entity PUL and the possibility of ocular involvement.- - - - - - - - - - ranking = 0.67481991390883keywords = lentiginosis (Clic here for more details about this article) |
5/31. Perioral dermatitis in childhood.BACKGROUND: Although perioral dermatitis has been well described in young women, little has been reported about this condition in children. OBJECTIVE: The purpose of this study was to define more clearly the features of perioral dermatitis in childhood. methods: Fourteen children with perioral dermatitis were assessed for clinical features, therapeutic response, and possible etiologic factors. RESULTS: Fourteen cases of perioral dermatitis were seen in 16 months, far exceeding the expected prevalence in childhood. Although the childhood variant shares many characteristics with the adult form, children often have periocular and perinasal lesions, as well as a higher relative incidence in boys. Mid- to high-potency topical corticosteroids were used in seven of the patients (50%) and likely contributed to the pathogenesis. All children responded rapidly to treatment. CONCLUSION: Perioral dermatitis in childhood, often iatrogenic, is more common than previously reported.- - - - - - - - - - ranking = 0.57142857142857keywords = perioral (Clic here for more details about this article) |
6/31. Segmental lentiginosis with "jentigo" histologic pattern.We report a case of segmental lentiginosis (unilateral lentiginosis), that is, asymmetric distribution of lentigines on one side of the body, in a 23-year-old woman. Lesions involved the right side of the face and the cervical region, mostly within the area of division of the trigeminal nerve. Histologic examination disclosed a lentiginous pattern as well as some nests of melanocytes at the dermal-epidermal junction (so-called jentigo pattern). Similar cases have been described in the literature under the term "zosteriform lentiginous nevus," which in our opinion makes for confusion since the same term has also been used to describe cases that fit the diagnostic criteria for speckled lentiginous nevus (nevus spilus).- - - - - - - - - - ranking = 0.80978389669059keywords = lentiginosis (Clic here for more details about this article) |
7/31. mycosis fungoides mimicking perioral dermatitis.A 71-year-old woman under PUVA-treatment for mycosis fungoides developed erythematous patches around the nasolabial folds and papules on the chin with clinical features of perioral dermatitis. histology showed a specific infiltrate of mycosis fungoides with predominance of medium to large-sized pleomorphic lymphocytes and immunoblasts. Immunohistochemical analysis revealed the T-phenotype of the neoplastic cells. Small clusters of b-lymphocytes could also be observed within the infiltrate. Perioral dermatitis-like lesions can be added to the spectrum of rare and unusual clinical manifestations of mycosis fungoides.- - - - - - - - - - ranking = 0.71428571428571keywords = perioral (Clic here for more details about this article) |
8/31. A case of granulomatous rosacea: sorting granulomatous rosacea from other granulomatous diseases that affect the face.Granulomatous rosacea is a variant of rosacea that may present similar to other granulomatous diseases. We present the case of a 45-year-old woman with a 2-year history of facial erythema with multiple papules and pustules on the cheeks, chin, and glabella. The patient responded to minocycline, resulting in healing 6 months without residual scarring. This patient's clinical and histological presentation and treatment outcome are to our assessment consistent with granulomatous rosacea. However, other clinically and histologically related entities will be discussed. These entities include, but are not limited to, perioral dermatitis, granulomatous periorificial dermatitis, lupus miliaris disseminatus faciei, facial afro-caribbean eruption syndrome, and sarcoidosis.- - - - - - - - - - ranking = 0.14285714285714keywords = perioral (Clic here for more details about this article) |
9/31. Childhood granulomatous periorificial dermatitis: a controversial disease.The etiology, diagnosis and treatment of childhood granulomatous periorificial dermatitis (GPD) are highly controversial. Some authors underline the similarities between GPD and perioral dermatitis and consider both as part of a spectrum while other authors regard GPD as a distinctive condition. Clinically GPD is a papulo-pustular periorificial disease of the face which histopathologically shows a granulomatous perifollicular infiltrate. Because of its granulomatous pattern, GPD also has been related to cutaneous sarcoidosis. The clinical course is benign and self-limited. Topical steroids are regarded as either the main cause or a worsening factor. While topical treatment is occasionally effective, systemic antibiotic therapy of GPD is usually recommended. We report a "typical" case of GPD and review the literature to discuss the difficulties in its diagnosis and treatment.- - - - - - - - - - ranking = 0.14285714285714keywords = perioral (Clic here for more details about this article) |
10/31. New hydroxyisoflavans as contact sensitizers in cocus wood Brya ebenus DC (fabaceae).A 15-year-old girl developed perioral dermatitis and swelling of the lips, having played a flute made of cocus wood for 2 years. patch tests with wood shavings, as well as with subsequently isolated constituents named Cocus I and Cocus II, were strongly positive. After complete purification, both contact allergens were identified as isoflavan derivatives. While Cocus I was shown to be 7,8-dihydroxy-2',4',5'-trimethoxyisoflavan, the structure of Cocus II could not be elucidated exactly. It could have been either 7,8,3'-trihydroxy-2',4'-dimethoxyisoflavan or 7,8,2'-trihydroxy-3',4'-dimethoxyflavan. The exact position of the hydroxy and methoxy group in C-2' and C-3' can be determined only by complete synthesis of both compounds or by isolation of greater amounts of Cocus II for further oxidation experiments. Due to the stronger patch test reaction and the higher yield of Cocus I in the wood, this hydroxyisoflavan must be recognized as the main contact allergen.- - - - - - - - - - ranking = 0.14285714285714keywords = perioral (Clic here for more details about this article) |
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