1/45. A case of primary transitional cell carcinoma of the fallopian tube.The primary carcinoma of the fallopian tube is the rarest of all gynecologic malignancies and histologically most of them are adenocarcinomas. Primary transitional cell carcinomas are extremely rare in the fallopian tube. A 63-year-old postmenopausal woman presenting with lower abdominal pain was found to have a left adnexal mass. Exploratory laparotomy revealed a mass arising from the fallopian tube with the histologic features of transitional cell carcinoma. light and electron microscopic studies supported the notion of transitional cell carcinoma. The tumor was extended to the muscle layer and confined to the left fallopian tube without metastasis. The patient received 3 courses of systemic cisplatin-based chemotherapy and has been well with no evidence of recurrence until August, 1998.- - - - - - - - - - ranking = 1keywords = gynecologic (Clic here for more details about this article) |
2/45. Post-hysterectomy fallopian tube carcinoma presenting with a positive Papanicolaou smear.BACKGROUND: Fallopian tube carcinoma is a rare gynecologic malignancy. The majority of women present with vaginal bleeding and have advanced disease. CASE: A 76-year-old woman presented 34 years after vaginal hysterectomy with a routine Papanicolaou smear showing adenocarcinoma. Rectovaginal examination was remarkable for thickening at the vaginal apex. colposcopy found a pinpoint opening in this area, and a cytobrush passed through the opening confirmed adenocarcinoma. Pelvic ultrasound, computed tomography scan, and CA 125 were normal. At laparotomy, the right fallopian tube and ovary were adherent to the vaginal apex. A grade II papillary serous adenocarcinoma confined to the tube was discovered. CONCLUSION: According to a medline search, this is the third report detailing a unique presentation of fallopian tube carcinoma after hysterectomy and possibly the first detected with positive Papanicolaou cytology.- - - - - - - - - - ranking = 1keywords = gynecologic (Clic here for more details about this article) |
3/45. Metachronous carcinoma of the vulva and fallopian tube.BACKGROUND: Metachronous carcinoma of the vulva and fallopian tube is an unusual co-occurrence of gynecological malignancies. A report of such a case that developed and recurred over a 7-year period is presented. CASE: A 53-year-old G3P3 female presented with a verrucous carcinoma of the vulva and a serous papillary adenocarcinoma of the left fallopian tube metachronously. To investigate a possible association between the co-occurrence of the rare neoplasms and factors associated with multiple gynecological malignancies, we analyzed the status of human papillomavirus infection and dna mismatch repair deficiency as indicated by microsatellite instability. All samples analyzed were negative for these factors. CONCLUSION: The present results support the possibility that metachronous carcinomas of the vulva and fallopian tube involve unknown etiological factors or arise independently.- - - - - - - - - - ranking = 2keywords = gynecologic (Clic here for more details about this article) |
4/45. Germline BRCA2 mutation in a patient with fallopian tube carcinoma: a case report.OBJECTIVES: Fallopian tube carcinoma is similar to ovarian and peritoneal carcinoma with respect to histology, response to chemotherapy, and prognosis. BRCA germline mutations have been commonly reported in ovarian and peritoneal carcinoma but rarely in other gynecologic cancers. methods: A patient with fallopian tube carcinoma and a family history of ovarian carcinoma underwent genetic counseling and BRCA testing as did her daughter. RESULTS: The patient and her daughter were found to have a germline BRCA2 mutation. CONCLUSION: Like a family history of ovarian or peritoneal carcinoma, the occurrence of fallopian tube cancer should alert the clinician to the possibility of an abnormality in the breast cancer susceptibility 1 or 2 genes.- - - - - - - - - - ranking = 1keywords = gynecologic (Clic here for more details about this article) |
5/45. Long-term survival of a patient with fallopian tube cancer presenting with a supraclavicular mass.BACKGROUND: Five-year survival of patients with stage IV cancer of the fallopian tube is poor. Furthermore, patients with gynecological cancers presenting with a supraclavicular mass generally have an unfavorable prognosis. CASE REPORT: We describe a 70-year-old patient who presented with a left supraclavicular mass. The mass was removed and histology showed metastatic papillary adenocarcinoma strongly suggestive of papillary serous carcinoma. Abdominal hysterectomy and salpingo-oophorectomy showed a primary carcinoma of the fallopian tube. Postoperatively the patient received six cycles of carboplatin-based chemotherapy and is alive and well with no evidence of disease 5 years and 10 months after the primary diagnosis. CONCLUSION: Surgery and adjuvant carboplatin-based chemotherapy seem justified even in older patients with fallopian tube cancer and distant metastasis at the time of diagnosis.- - - - - - - - - - ranking = 1keywords = gynecologic (Clic here for more details about this article) |
6/45. Recurrent metastatic fallopian tube carcinoma in pregnancy.BACKGROUND: Fallopian tube cancer is the rarest of all gynecologic cancers. An extensive literature search on medline reveals no previous case reports of fallopian tube carcinoma in association with a term pregnancy. CASE: A woman with surgical stage IIB fallopian tube carcinoma was treated with limited staging laparotomy, as per the patient's fertility wishes, followed by adjuvant cis-platinum and paclitaxel (Taxol). One year following chemotherapy, she conceived. She was noted to have an asymptomatic intraabdominal recurrence at 16 weeks. The patient completed 37 weeks of pregnancy without further therapy according to her wishes. She subsequently underwent a cesarean section with optimal tumor reduction surgery. carboplatin and paclitaxel were reinstituted, achieving partial response. She is presently alive with stable disease status 6 months after completing her salvage chemotherapy. CONCLUSION: This is the first case report of recurrent fallopian tube cancer in pregnancy.- - - - - - - - - - ranking = 1keywords = gynecologic (Clic here for more details about this article) |
7/45. Primary carcinoma of the fallopian tube.Carcinoma of the fallopian tube is the least common of the gynecologic malignancies. Because of its rarity and the absence of typical symptoms, preoperative diagnosis is seldom made. Patient as well as physician delay in diagnosis is often considerable. There are no reliable laboratory aids available to enhance the discovery of this tumor. However, routine periodic pelvic examinations with laparoscopic examination of any significant adnexal enlargement in postmenopausal women should decrease the discovery time. Certainly, unexplained vaginal discharge or bleeding particularly when associated with a pelvic mass, should increase one's suspicion. Conventional surgical treatment can be curative if the tumor has not exceeded the confines of the tube and has not involved the serosa. Regardless, the prognosis for patients with primary carcinoma of the fallopian tube is grim.- - - - - - - - - - ranking = 1keywords = gynecologic (Clic here for more details about this article) |
8/45. Fallopian tube cancer in a BRCA1 mutation carrier: rapid development and failure of screening.We report a case of fallopian tube cancer that developed in a woman with a germ-line BRCA1 mutation. The notable feature of this case was the extremely rapid growth of the cancer, which precluded early diagnosis. Preventive gynecologic surgery in BRCA1/2 mutation carriers should probably always include bilateral salpingectomy.- - - - - - - - - - ranking = 1keywords = gynecologic (Clic here for more details about this article) |
9/45. Fallopian tube carcinoma presenting with a brain metastasis.BACKGROUND: Fallopian tube carcinoma is a rare gynecologic cancer. An extensive literature search reveals no previous case report of fallopian tube carcinoma presenting with a brain metastasis. CASE: A 63-year-old woman presented with 3 weeks of progressive left-sided weakness. CT scan of the brain revealed a solitary lesion in the right parietal lobe. The patient underwent a complete resection, followed by whole-brain radiation therapy. Pathologic review demonstrated adenocarcinoma with follicular structures. A directed workup revealed a large right adnexal mass. She underwent resection of a large fallopian tube carcinoma with normal ovaries. She recovered from surgery and is receiving combination chemotherapy. CONCLUSION: This is the first case report of a fallopian tube carcinoma presenting as a brain metastasis.- - - - - - - - - - ranking = 1keywords = gynecologic (Clic here for more details about this article) |
10/45. Arterial thrombosis in a gynecologic oncology patient: evaluation and management.BACKGROUND: Arterial thrombosis is an extremely rare complication in gynecologic oncology with only two cases previously reported in the literature. Presentation, evaluation, and treatment varied considerably in all previous reports of arterial thrombosis associated with any malignancy. CASE: We report a case of discontinuous arterial thrombosis in the upper extremity of a patient with fallopian tube cancer. Her initial evaluation, done in the acute setting of the thrombosis, revealed multiple thrombophilia abnormalities, including an elevated factor viii, and a borderline positive lupus anticoagulant. follow-up studies over 2 years showed resolution of all coagulation abnormalities, thus indicating no genetic propensity for thrombosis. CONCLUSION: This case highlights the need for appropriate timing of the initial laboratory studies and follow-up so that patients can be managed appropriately.- - - - - - - - - - ranking = 5keywords = gynecologic (Clic here for more details about this article) |
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