1/9. subcutaneous fat necrosis of the newborn.subcutaneous fat necrosis of the newborn (SFN) is an uncommon disease that affects newborns who have suffered from tissue hypoxia during or following delivery. This disease appears during the first weeks of life. It consists of indurate, erythematous or purple-erythematous nodules and plaques in the skin. histology of a biopsy specimen shows granulomatous necrosis in the subcutis with radial crystals in lipocytes and giant cells. Spontaneous resolution in a few weeks is usual, but the mobilization of calcium from the necrosed subcutis together with the action of some hormones may cause hypercalcemia and certain serious complications. A newborn female child developed SFN after dystocic delivery causing cerebral frontal lobe hemorrhage. The skin nodules resolved spontaneously in a few weeks and no complications were observed 1 year later.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
2/9. Lipomembranous fat necrosis in three cases of testicular torsion.AIMS: To describe for the first time a lesion termed lipomembranous fat necrosis (LFN) in three patients with spermatic cord torsion. methods AND RESULTS: We reviewed 386 testes and their epididymides and spermatic cords which had been removed for testicular infarction. For the three cases showing LFN, a battery of histochemical tests (including periodic acid-Schiff (PAS), orcein, sudan black and Perls stains) was applied and clinical histories and laboratory data were also investigated. Findings were similar in the three specimens. The testes showed a central group of necrotic seminiferous tubules which were surrounded by granulation tissue consisting of macrophages, multinucleated giant cells, lymphocytes, plasma cells and fibrous connective tissue at the periphery of the lesion. The spermatic cord showed thrombosed veins surrounded by fat necrosis showing cystic cavities which were bounded by wavy hyaline membranes. These stained with sudan black, PAS (before and after diastase digestion) and orcein and presented yellowish-green autofluorescence. CONCLUSIONS: Lipomembranous fat necrosis of the spermatic cord is a distinctive entity which seems to be related to spermatic cord torsion and the differential diagnosis of which should be established with regard to the presence of parasites, sclerosing lipogranuloma and granuloma evoked by rupture of a testicular prosthesis.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
3/9. Studies on subcutaneous fat necrosis of the newborn.biopsy specimens from the skin and subcutaneous fat tissue of four cases with neonatal subcutaneous fat necrosis were made and investigated by light and electron microscopy at 2, 4, and 6 weeks, and 5 months (Case 2) from the onset of the disease. Three stages of ultrastructural change of fat cells were observed. The evolution of crystal formation in the fat cells was seen and phagocytosis of crystals and fat droplets by macrophages and foreign-body giant cells was also noted. In the light microscope accumulation of calcium concretions in the spaces between and inside the fat cells was found. In the electron microscope we detected foci of highly electron-dense granules, which were similar in distribution and structure to calcium salts stained with the von Kossa method. Changes in small and medium size blood vessels were observed.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
4/9. subcutaneous fat necrosis of newborn: report of two cases.subcutaneous fat necrosis of newborn (SFNN) is an uncommon disorder. Submandibular lesion and tissue eosinophilia have not been documented. Two patients with unusual location and unusual pathological findings are reported. Both patients were giant babies, delivered by vaginal route spontaneously with birth injury. Asymptomatic subcutaneous nodules were found over the submandibular area at the ages of 16 and 6 days respectively. Nodules disappeared spontaneously at the age of one month in the first, and two months in the second patient. Histopathological examination of the nodules revealed features typical for SFNN: lobular panniculitis with fat necrosis and radiating needle-shaped clefts within multinucleated histiocytes. In addition to mononuclear cells, eosinophils were abundant in the infiltrate. Because of these unusual features, it is suggested that SFNN should be considered in the differential diagnosis of submandibular subcutaneous nodule in the newborn, clinically; and of lobular panniculitis with eosinophilia, histologically.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
5/9. Coexistence of arthritis, subcutaneous fat necrosis, and pseudocyst of pancreas.A 29-year-old woman was observed with subcutaneous fat necrosis, arthritis, and a giant pseudocyst of the pancreas. Surgical removal of the cyst resulted in a remission of the inflammatory process in the joints as well as within the subcutaneous tissue.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
6/9. Synovial fat necrosis associated with ischemic pancreatic disease.A 59-year-old man with ischemic pancreatic disease, polyarthritis, and cutaneous nodules has shown histopathologic findings indicative of disseminated fat necrosis in a percutaneous biopsy specimen from the right knee. The histopathologic findings in the synovium included necrotic fat cells, distorted fat cells and adjacent lymphocytes, lipid laden histiocytes, and giant cells. In prior histopathologic studies of the joint involvement associated with this disorder, fat cell necrosis has been found only in the periarticular tissues, and the synovium has appeared normal or showed nonspecific inflammation. However, the present study shows that the synovial membrane may also be the site of fat necrosis and an associated inflammatory reaction; thus patients with this disorder may manifest arthritis in addition to periarthritis.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
7/9. Bilateral fat necrosis of the breast: report of a case.A rare case of bilateral fat necrosis of the breast is reported. The patient was a 50-year-old unmarried woman having no history of trauma, disease or surgery of the breast. In the bilateral breasts, ill-defined, firm masses with skin retraction were noted. Bilateral breast cancer was diagnosed clinically. However, both lesions showed histologically chronic granulomatous inflammation with foci of fatty necrosis, infiltration of lymphocytes, plasma cells, lipid containing foamy cells, foreign body giant cells engurfing choresterol-crystals, and calcification. "Paraffinoma" was thus suspected, but there was no history of cosmetic mammoplasty and histochemical studies failed to demonstrate saturated lipid indicating paraffin or other mineral oils.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
8/9. Fine-needle aspiration biopsy of subcutaneous fat necrosis of the newborn.This report provides the first description of the fine-needle aspiration biopsy findings in a case of subcutaneous fat necrosis of the newborn. While initial interpretation of the aspirate smears was suspicious for a neoplastic process, subsequent incisional biopsy confirmed the benign nature of the lesion. review of the cytologic material revealed rare, negatively stained, needle-shaped crystals within histiocytes and multinucleate giant cells. In the appropriate clinical setting, and given a mixture of lymphocytes, histiocytes, and multinucleate giant cells in the aspirate smears, we believe the finding of negatively stained needle-shaped crystals can strongly suggest the diagnosis of subcutaneous fat necrosis of the newborn.- - - - - - - - - - ranking = 2keywords = giant (Clic here for more details about this article) |
9/9. subcutaneous fat necrosis of the newborn: light and electron microscopic studies.Specimens from two cases of subcutaneous fat necrosis of the newborn were studied by light and electron microscopy. crystallization of the fat cell started with clearing of the central fat droplet, followed by the appearance of cylindrical crystals. The fat crystals were phagocytosed by cytoplasmic projections of macrophages as well as by foreign body giant cells. calcium deposits were demonstrated within the central fat droplet of the degenerated fat cell of Case 2.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |