1/58. Synchronous multicentric giant cell tumour: a case report with review of literature.Synchronous multicentric giant cell tumour (MGCT) is a rare occurrence. We report a young woman who presented with a synchronous skull and lower shaft femur giant cell tumour, who had previously received radiotherapy to both the sites, it being deemed inoperable at initial assessment.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
2/58. De novo malignant transformation of giant cell tumor of bone.Two cases of malignant lesions are reported, both of which arose secondary to an originally benign giant cell tumor (GCT) of bone. The first case was a typical benign GCT, which occurred in the left proximal tibia of a 31-year-old woman. The tumor was treated by curettage and bone grafting. However, it recurred twice during 15 years of follow-up. The second recurrence showed that the lesion histologically had turned into malignant fibrous histiocytoma. The second case also started as an initially benign GCT that arose in the left distal femur of a 41-year-old man. The patient underwent curettage and bone grafting. The lesion recurred 13 years postoperatively. The histological appearance of the recurrent tumor showed it to be an osteogenic sarcoma. In both patients, radiation and never been given. Malignant transformation has rarely been reported in patients with GCT of bone who have not received radiation treatment.- - - - - - - - - - ranking = 0.83333333333333keywords = giant (Clic here for more details about this article) |
3/58. Atypical hip pain origin in a young athletic woman: a case report of giant cell carcinoma.Primary bone tumors are infrequently encountered in a sports medicine practice. We describe a case in which a young athletic woman with a medical history significant for ulcerative colitis initially presented to our clinic with chronic hip pain. Her initial roentograms were negative for boney pathology and her history and examination were consistent with trochanteric bursitis. However, follow-up radiographs performed 9 months later showed a radiolucent mass that eventually, after open biopsy and histologic evaluation, was determined to be giant cell tumor. This case shows the importance of repeat radiographic studies in patients whose joint pain does not respond or responds slowly to conservative therapy, despite initial normal findings. It also establishes that radiographic findings do not always correlate with actual disease process, for this lesion was found to be giant cell carcinoma--a diagnosis contrary to the original diagnosis of clear cell chondrosarcoma that was suggested by radiology.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
4/58. Giant cell tumor and the skeletally immature patient.Conventional wisdom suggests that giant cell tumor (GCT) does not occur in the skeletally immature individual; however, we believe that GCTs of bone, though rare, do occur in children. We are reporting the occurrence of GCT of bone in three patients who were skeletally immature at the time of their initial presentation. In our review of the reports since 1954 that document this condition, we were also able to find a total of 318 patients, of whom 130 were skeletally immature at the time of their tumor presentation. From the data compiled, we found a 7.5% incidence of GCT of bone in skeletally immature individuals at a mean age of 10.5 years. Based on our review and the experience with our three patients, we believe the diagnosis of GCT of bone should be considered in the differential diagnosis of a destructive lesion of bone in skeletally immature individuals. Giant cell tumor in the skeletally immature is being reported here to better define its incidence and increase awareness of its occurrence. Management options will also be discussed.- - - - - - - - - - ranking = 0.16666666666667keywords = giant (Clic here for more details about this article) |
5/58. Whole-lung radiotherapy for giant cell tumors of bone with pulmonary metastases.Three patients initially diagnosed with benign giant cell tumors of bone who had lung metastases develop were treated with whole-lung radiotherapy as part of the therapeutic treatment of their distant disease. External beam therapy to 16 Gy in 10 fractions was delivered to the whole lung, with a boost of 35 to 45 Gy to sites of gross metastatic disease. One patient's lung metastases progressed after treatment, and the patient soon died. The two other patients were long-term survivors (7.5 years and 13 years) with complete resolution of detectable disease. One of the two patients required two additional courses of local radiation to metastatic sites. The authors therefore recommend whole lung radiotherapy to 16 Gy with an additional boost to 35 to 45 Gy to gross disease as an option for patients with pulmonary metastases who are poor surgical candidates, who refuse thoracic surgery, whose disease is technically unresectable, or whose disease recurs or progresses after surgery or chemotherapy.- - - - - - - - - - ranking = 0.83333333333333keywords = giant (Clic here for more details about this article) |
6/58. Coexistence of primary bone tumours: report of 4 cases of collision tumours.OBJECTIVE: To report, in 4 patients, the occurrence of 2 different primary tumours in proximity in the same bone. Three patients had osteosarcomas, and 1 had a giant cell tumour; all had coincident metaphyseal fibrous defect. methods: Four patients (2 women, 1 man and 1 boy; 18, 25, 24 and 10 years of age, respectively) presented with progressive pain in the knee and distal thigh. All were studied by radiography, magnetic resonance imaging was done in 3 patients, and diagnostic open biopsy was performed for all. RESULTS: Radiologic studies demonstrated tumours in the distal end of the femur in all 4 patients. biopsy tissue showed a metaphyseal fibrous defect in all, with coexistence of an associated giant cell tumour in 1 patient and an osteosarcoma in each of the others. In all cases, the metaphyseal fibrous defect was penetrated by the adjacent tumour. CONCLUSIONS: Despite the relative prevalence of metaphyseal fibrous defect, giant cell tumour and osteosarcomas in the distal end of the femur and their occurrence in approximately the same age group, their association has rarely been reported. As both giant cell tumours and osteosarcomas are usually diagnosed late in their clinical course, they may outgrow and destroy any evidence of pre-existing metaphyseal fibrous defect. The rate of destruction is also influenced by the distance between the 2 lesions--the shorter the distance, the earlier the destruction.- - - - - - - - - - ranking = 0.66666666666667keywords = giant (Clic here for more details about this article) |
7/58. Malignancy in giant cell tumor.Malignant giant cell tumor is a confusing term that in the past has been used to describe different types of giant cell-rich tumors. We try to clarify this term in this report. We consider two types of malignancy in giant cell tumor of bone: "primary" when it arises in juxtaposition to a benign giant cell tumor and 'secondary' when it arises at the site of a previously treated giant cell tumor. Here we present a case of primary malignancy in giant cell tumor that was initially not recognized as a malignancy. On radiography and histology of frozen sections the lesion had the appearance of a conventional giant cell tumor of bone. After curettage, the permanent histology slides showed areas of highly malignant osteosarcoma juxtaposed to areas of benign giant cell tumor. The patient was treated with chemotherapy and wide resection of the tumor.- - - - - - - - - - ranking = 2keywords = giant (Clic here for more details about this article) |
8/58. Multifocal, metachronous, giant cell tumor of the lower limb.A case of multifocal giant cell tumor in a skeletally immature male with documented metachronous disease of the lower limb is described followed by a review of the literature including treatment options and their outcomes.- - - - - - - - - - ranking = 0.83333333333333keywords = giant (Clic here for more details about this article) |
9/58. Tc-99m-tetrofosmin scintigraphy in a primary giant cell tumor of bone with pulmonary metastases.Giant cell tumor (GCT) is usually considered to be a benign entity. In rare cases, pulmonary metastases can be observed. This report documents the 99mTc-tetrofosmin scan findings of a conventional GCT of the femur and developed pulmonary nodules. The lung lesions were felt to be an example of benign metastases. According to our review, this is the first case in the literature demonstrating tetrofosmin accumulation in a GCT of bone and its pulmonary metastases.- - - - - - - - - - ranking = 0.66666666666667keywords = giant (Clic here for more details about this article) |
10/58. Giant cell tumor of the foot.The author discusses giant cell tumor, often a monostotic bone tumor, as it affects the lower extremity. The lesion is most common at the ends of long tubular bones, and may transform into malignant pathology. Surgical resection with or without bone grafting is an accepted technique for treatment. Recurrent abnormality is possible, and close follow-up of these patients is recommended.- - - - - - - - - - ranking = 0.16666666666667keywords = giant (Clic here for more details about this article) |
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