1/4. Case of the Month. Giant multiple intraductal papilloma of the breast: a case report and review of the literature.A case is described of multiple intraductal papilloma of the breast in a 39 year old Micronesian female who presented to our institution with a 2 year history of spontaneous bloody nipple discharge with an associated giant cystic breast mass. This case report illustrates an unusual presentation of a rare benign breast lesion. The clinical, radiographic, and pathologic features of this disease process are discussed; the literature is reviewed; and management options are discussed.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
2/4. Intracytoplasmic eosinophilic inclusion bodies in breast cyst fluids are giant lysosomes.Electron microscopic (EM) studies were performed on a benign breast cyst fluid to determine the nature of intracytoplasmic eosinophilic inclusion bodies (EIBs). EIBs were usually found in macrophages and had the ultrastructural appearance of giant lysosomes. EIBs contained cellular material and granular debris; when viewed by EM, the contents were somewhat variable, depending on the nature of phagocytosed material and the extent of enzymatic breakdown. Usually the phagocytosed material had a rather homogeneous, finely granular texture. Occasionally cell remnants, including cytoplasmic organelles, were preserved inside the EIBs. Since the "host" macrophages were in various states of degeneration, the formation of EIBs appears to be related to a severe disturbance in the macrophage cellular function. This study showed that EIBs in cells from breast cyst fluids are not viral particles.- - - - - - - - - - ranking = 5keywords = giant (Clic here for more details about this article) |
3/4. Breast carcinoma with tumor giant cells. Report of a case with fine needle aspiration cytology.A 31-year-old woman presented with a cystic mass in the left breast. At fine needle aspiration (FNA), the mass felt gritty, and a firm mass remained after drainage of the cyst. Cytologic examination of the aspirate showed mononucleated malignant cells and an array of bizarre malignant multinucleated giant cells. A diagnosis of carcinoma of breast with malignant giant cells was made. Subsequent histologic study of the lesion showed a central cystic cavity lined by bizarre tumor giant cells. Immunocytochemistry and lectin cytochemistry confirmed the epithelial nature of the malignant giant cells. The entities that may yield giant cells on FNA of breast masses are discussed.- - - - - - - - - - ranking = 9keywords = giant (Clic here for more details about this article) |
4/4. Mammary carcinoma with osteoclastlike giant cells cytologically mimicking benign breast disease. A case report.BACKGROUND: Mammary carcinoma with osteoclastlike giant cells (OCLGCs) is a rare tumor. Few reports on the fine needle aspiration (FNA) findings are available. This case had cytologic findings overlapping with benign breast disease. CASE: A 50-year-old woman presented with multiple masses in her right breast and a 2-cm right axillary lymph node. Cytologic scrapings and FNA of the same breast mass showed large cohesive, two-dimensional epithelial cells with a uniform distribution of small, bland nuclei. Discohesion, single cells with features of malignancy, cytologic atypia and mitosis were lacking. Many OCLGCs were present. CONCLUSION: The cytologic features of this rare type of breast carcinoma need to become familiar to pathologists to avoid a false negative diagnosis.- - - - - - - - - - ranking = 5keywords = giant (Clic here for more details about this article) |